A5101530220- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Glioma Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Dysphagia Assessment and Management
- Cancer-related Molecular Pathways
- Regulation of Appetite and Obesity
- Botulinum Toxin and Related Neurological Disorders
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Neurological Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Amino Acid Enzymes and Metabolism
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Histone Deacetylase Inhibitors Research
Taipei Medical University Hospital
2020-2024
Taipei Medical University
2010-2024
Fuzhou University
2024
Tri-Service General Hospital
2018-2024
Qingdao University
2022
Qingdao Municipal Hospital
2022
Weatherford College
2022
Shanghai Children's Hospital
2017-2022
Shanghai Jiao Tong University
2022
Wan Fang Hospital
2010-2018
// Medhi Wangpaichitr 1, 2 , Chunjing Wu 1 Ying Li 3 Dan J.M. Nguyen 4 Hande Kandemir 5 Sumedh Shah Shumei Chen 6 Lynn G. Feun Jeffrey S. Prince Macus T. Kuo 7 and Niramol Savaraj Miami VA Healthcare System, Research Service, Miami, FL, USA Department of Surgery, Cardiothoracic University Medicine, Hematology/Oncology, Biology, School Koc University, Istanbul, Turkey Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan Translational Molecular Pathology, Texas MD Anderson...
Abstract Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential therapeutic target for obesity related complications. This study aimed to further elucidate the role IL‐4 in regulating hypothalamic appetite‐controlling neuropeptides using dysfunctional Leptin 145E/145E mice experimental model. significantly reduces body weight, food intake, serum glucose levels. data...
Background. Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor. It a rapidly progressive, highly recurrent, fatal intracranial neoplasm, and demand for novel treatment urgent. Valproic acid (VPA) potential anticancer agent that belongs to class histone deacetylase (HDAC) inhibitors, targeting epigenetic control gene functions in cancer cells. This drug has been administered prevention or seizure disorder GBM patients; therefore, retrospective analysis may...
This study aimed to retrospectively investigate the factors related pediatric obstructive sleep apnea–hypopnea syndrome (OSAHS) with attention deficit hyperactivity disorder (ADHD) in children younger than 6 years and those older years. A total of 437 who were hospitalized due OSAHS between January 2014 December reviewed. The further divided into group + ADHD group. general characteristics, OSA-18 quality life, intention-hyperactivity score, polysomnographic parameters (apnea–hypopnea index...
ABSTRACT Background and Aims: The aim of the present study was to evaluate proinflammatory anti‐inflammatory cytokine levels in children with irritable bowel syndrome (IBS). Patients Methods: Thirty‐five IBS (17 diarrhea‐predominant, 7 constipation‐predominant, 11 mixed type) 25 healthy as controls (HCs) were enrolled. All participants completed a questionnaire recording duration, severity, associated academic social influences. Peripheral blood mononuclear cells isolated cultured for 24...
We investigated the protective efficacy of l-theanine (LT), major amino acid components green tea, on chronic constriction injury (CCI) sciatic nerve-induced neuropathic pain (NP) development and neuronal functional changes in rats. Rats with NP induced by CCI left nerve sham-operated rats received LT or saline solution, sensitive tests thermal hyperalgesia mechanical allodynia. Motor sensory conduction velocities were measured after surgery. Subsequently, sacrificed; was excised,...
This study aimed to investigate the outcome in patients with aspiration pneumonia during definitive concurrent chemoradiotherapy for head and neck cancer. The data of 595 cancer treated by were reviewed. Forty-one identified as developing symptomatic treatment analysed this study. definition fit three criteria: (1) at least one event or evidence grade 2 above dysphagia treatment; (2) clinical radiographic signs pneumonitis; (3) no 4 haematological toxicity before outbreak pneumonia....
Abstract Medulloblastoma ( MB ) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors apoptosis proteins IAP small‐molecule LCL 161 or LBW 242) combined with chemotherapy have synergistic antiproliferative effects on cells. The antitumor combination treatments happen through induction autophagy and caspase‐3/7‐activated apoptosis. Here, we investigated silencing cell cycle regulation. discovered treatment their conventional (vincristine cisplatin),...
Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with inhibitors (BRAFi) despite a high initial response rate. Our previous study has uncovered that BRAFi-resistant melanoma (BR) cells vulnerable arginine deprivation. It been reported naïve undergo autophagy and re-express argininosuccinate synthetase 1 (ASS1) enable them synthesize for survival when encountering Abolishing these two factors in BR confers sensitivity In this report, we further...
Glucocorticoid therapy, especially at higher doses, is associated with significant adverse side effects including osteoporosis. Leptin, secreted from adipose tissue, has diverse on bone tissue regulation. As glucocorticoids stimulate leptin synthesis and secretion directly in we hypothesised that dexamethasone (DEX) induced osteoporosis may, part, be mediated by an osteoblast dependent leptin-leptin receptor pathway. Human cells expressed receptors (Ob-Ra Ob-Rb). DEX increased leptin, Ob-Ra...
Pigment epithelium-derived factor (PEDF) plays an important role in insulin resistance (IR). The study aims to investigate the effect of rosiglitazone, sensitizer, on PEDF production and release both vivo vitro. Male SD rats were divided into normal control group, high-fat rosiglitazone group. Hyperinsulinemic euglycemic clamp was performed evaluate sensitivity. IR models 3T3-L1 adipocytes HepG2 cells established by hyperinsulinemic method. Glucose uptake examined validate adipocytes,...
Objective . Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent improve IR, on PEDF production both vivo and vitro. Methods SD rats were divided into normal control group, high fat group (HF group), metformin (MET group). Hyperinsulinemic euglycemic clamp was performed evaluate sensitivity. IR models 3T3-L1 HepG2 cells established then treated with inhibitor AMP...
Vitexin (VTX), a C-glycosylated flavone found in various medicinal herbs, is known for its antioxidant, anti-inflammatory, and neuroprotective properties. This study investigated the protective effects of VTX against orofacial dyskinesia (OD) rats, induced by haloperidol (HPD), along with mechanisms underlying these effects. OD was administering HPD (1 mg/kg i.p.) to rats 21 days, which led an increase frequency vacuous chewing movements (VCMs) tongue protrusion (TP). (10 30 mg/kg) given...
Abstract Atypical teratoid/rhabdoid tumors (ATRTs) are highly aggressive pediatric brain with sensitivity to proteasome inhibitors in preclinical models. We evaluated the feasibility of combining inhibitor bortezomib chemotherapy. Patients aged 0-20 years newly diagnosed ATRT were enrolled from January 2022 through December 2023. A modified Medical University Vienna (MUV)-ATRT regimen was used. They treated 1.3 mg/m2/dose given intravenously or subcutaneously twice a week for 2 weeks...
<i>Background:</i>Intensive chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is effective for refractory systemic lupus erythematosus (SLE). When intensive immunoablative but nonmyeloablative, ASCT reconstitution, with the risk of reinfusing autoreactive lymphocytes, unnecessary. <i>Methods:</i>Four children aged 12–16 years were enrolled, 3 WHO class IV nephritis, 2 hemolytic anemia and 1 thrombocytopenia. Median disease duration...
Alzheimer’s disease is the most frequent form of dementia in aging population and presently world’s sixth largest cause mortality. With advancement therapies, several solutions have been developed such as passive immunotherapy against these misfolded proteins, thereby resulting clearance. Within this segment, encapsulated cell therapy (ECT) that utilize antibody releasing cells proposed with a multitude techniques under development. Hence, study, we utilized our novel patented Microtube...
Glioblastoma multiforme (GBM) has remained one of the most lethal and challenging cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, a narrow therapeutic index: slight dose increase can induce toxicities that outweigh its benefits. SN-38 is active metabolite accounts both anti-tumor efficacy toxicity. In our previous paper, we showed embedded into 50:50 biodegradable...
Denys–Drash syndrome (DDS) is characterized by early onset of nephropathy, genitalia malformation, and Wilms' tumor, where WT1 the gene that mutated in most patients. We report two de novo mutations found Chinese DDS children. Patient 1 was a boy with complete who presented progressive unilateral bilateral cryptorchidism, renal histology showing diffuse mesangial sclerosis (DMS). When patient 24 months old, liver ultrasound showed multiple nodules, died pneumonia month later. The novel...