A5062274621- Sulfur Compounds in Biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Cardiac Fibrosis and Remodeling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Traditional Chinese Medicine Studies
- Inflammasome and immune disorders
- Pregnancy and preeclampsia studies
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Multiple and Secondary Primary Cancers
- Healthcare and Venom Research
- Endometrial and Cervical Cancer Treatments
- Climate Change and Health Impacts
- Oral health in cancer treatment
- Enhanced Recovery After Surgery
- Vascular Malformations Diagnosis and Treatment
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Syphilis Diagnosis and Treatment
- Esophageal and GI Pathology
Children's Hospital of Capital Institute of Pediatrics
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Peking University Third Hospital
2013-2022
Zhejiang Provincial People's Hospital
2017-2022
Peking University
2013-2022
Hangzhou Medical College
2022
Wenzhou Medical University
2021-2022
Guangdong Academy of Medical Sciences
2015
ORIGINAL RESEARCH article Front. Pharmacol., 28 September 2017Sec. Experimental Pharmacology and Drug Discovery Volume 8 - 2017 | https://doi.org/10.3389/fphar.2017.00675
Abstract Oxidative stress and inflammation play crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Most patients with COPD show a poor response to corticosteroids. Hydrogen sulfide (H 2 S ) has been implicated COPD, but its expression effects lung tissue from are not clear. In peripheral samples 24 patients, we found that compared nonsmokers, protein level cystathionine-γ-lyase (CSE) was decreased smokers patients. CSE mRNA increased cystathionine-β-synthase...
Endoplasmic reticulum stress (ERS) and inflammation participate in cardiac fibrosis. Importantly, a novel paracrine/autocrine peptide intermedin1-53 (IMD1-53) the heart inhibits myocardial fibrosis rats. However, mechanisms are yet to be fully elucidated.Myocardial apolipoprotein E-deficient (ApoE -/-) mice neonatal rat fibroblasts (CFs) were induced using homocysteine (Hcy).IMD1-53 inhibited vivo vitro. Picrosirius red staining showed that IMD1-53 reduced interstitial collagen deposition...
This study aimed to investigate the outcome in patients with aspiration pneumonia during definitive concurrent chemoradiotherapy for head and neck cancer. The data of 595 cancer treated by were reviewed. Forty-one identified as developing symptomatic treatment analysed this study. definition fit three criteria: (1) at least one event or evidence grade 2 above dysphagia treatment; (2) clinical radiographic signs pneumonitis; (3) no 4 haematological toxicity before outbreak pneumonia....
Background: Considerable studies showed associations between chronic obstructive pulmonary disease (COPD) and cardiovascular (CVD), we evaluated the role of endogenous hydrogen sulfide (H2S)/homocysteine (Hcy) in patients with COPD combined CVD. Methods: Fifty one stable were enrolled (25 COPD, 26 + CVD). Lung function, sputum, peripheral blood samples, serum H2S, Hcy, high-sensitivity C-reactive protein (hs-CRP) tumor necrosis factor-α (TNF-α) levels measured. Dyspnea, symptoms quality life...
Epithelial mesenchymal transition (EMT) is a contributing factor in remodeling events of chronic obstructive pulmonary disease (COPD). Hydrogen sulfide (H2S) has been implicated the pathogenesis COPD, but effect H2S regulating EMT and underlying mechanisms not clear. In this study, we assessed endoplasmic reticulum (ER) stress markers, markers associated signal molecules rat lungs, bronchial epithelial cells, human peripheral lung tissues to investigate mechanisms. We found that ER occurred...
To explore the clinical characteristics of children with adenoid hypertrophy (AH) and laryngopharyngeal reflux (LPR) by detecting expression pepsin in adenoids as a standard for AH LPR.
INTRODUCTION Chronic obstructive pulmonary disease (COPD) is one of the leading causes death in developed world and associated with a high individual socioeconomic burden.[1] It characterized by persistent airflow limitation that usually progressive an enhanced chronic inflammatory response airways lung to noxious particles or gases. Peri-bronchiolar fibrosis was occurred small early state COPD, then followed structure changes, finally became limitation.[2] Recent researches have shown...
Objective: To explore the relationship between endogenous hydrogen sulfide (H 2 S) and high-resolution computed tomography (HRCT) indexes in pulmonary vascular remodeling. Methods: A total of 94 stable chronic obstructive disease (COPD) patients were recruited for study.Plasma H S levels measured using fluorescence probe. Fluorescence quantitative polymerase chain reaction was used to measure synthase cystathionine-γ-lyase (CSE) mRNA cystathionine-β-synthesis enzyme (CBS) mRNA. The main...
The paper aims to combine mathematical statistics assess the effect of nutritional intervention in population nasopharyngeal cancer patients. Methodology. After following inclusion and exclusion criteria, a total 120 patients with carcinoma were selected. All are treated intensity-modulated radiotherapy (IMRT). nurse collects relevant clinical treatment data during patient. patient's radiotherapy, remeasures status indicators. Three months after completion patient will be reexamined by MRI,...
Objective: To investigate the role and mechanism of hydrogen sulfide (H2S) in rats with chronic obstructive pulmonary disease (COPD) related vascular remodeling. Methods: Twenty four healthy male Sprague-Dawley were randomly divided into 4 groups: control group, cigarette smoke (CS) CS+ Sodium hydrosulfide (NaHS) group DL-propargylglycine (PPG) group. Rats fed normally breathed clear air, for rest groups, passive inhalation method adopted to establish COPD model. After 8 weeks, corresponding...
Objective. To investigate the expression of miR-338-3p in nasopharyngeal carcinoma (NPC) and its relationship with STAT3 mRNA as well their clinical pathological parameters prognosis patients. Methods. From September 2016 to 2018, 71 patients NPC were selected group, samples tissues collected during operation. A total 23 who underwent biopsy due chronic nasopharyngitis control group mucosal collected. The expressions tissue two groups detected by real-time quantitative PCR, between was...