A5035280460- Glioma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cardiac tumors and thrombi
- Cervical Cancer and HPV Research
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Parasite Biology and Host Interactions
- Neurofibromatosis and Schwannoma Cases
- Neuroendocrine Tumor Research Advances
- Mollusks and Parasites Studies
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Vascular Malformations Diagnosis and Treatment
- Tumors and Oncological Cases
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Oral and Maxillofacial Pathology
- Pituitary Gland Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
Chang Gung University
2015-2024
Chang Gung Memorial Hospital
2015-2024
Linkou Chang Gung Memorial Hospital
2013-2024
University of Auckland
2024
Taoyuan Chang Gung Memorial Hospital
2017-2023
Sana Kliniken Duisburg
2021
Memorial Hospital of South Bend
2004-2011
Chang Gung Children's Hospital
2002-2010
I-Shou University
2008
National Tsing Hua University
2006
To assess the diagnostic accuracy of fused T2-weighted and high-b-value diffusion-weighted (DW) magnetic resonance (MR) images at 3 T for evaluation myometrial invasion in patients with endometrial cancer.Institutional review board approval informed consent were obtained. From May 2006 to October 2007, 48 consecutive aged 25-80 years (mean age, 57 years) who had cancer prospectively enrolled preoperative by using a 3-T MR unit. Two radiologists interpreted depth on images, dynamic contrast...
Epidemiological studies have reported an association between chronic cadmium (Cd) exposure and increased cardiovascular risk; however, their causal relationship remains unclear. The aim of this study is to explore the effects Cd on cardiac arterial systems in mice. According concentration chloride drinking water, male mice were randomly divided into control low-dose high-dose groups. intervention duration was 12 weeks. In tissues, led focal necrosis, myofibril disarray, perivascular...
To investigate how single or fractionated doses of radiation change the microenvironment in transgenic adenocarcinoma mouse prostate (TRAMP)-C1 tumors with respect to vascularity, hypoxia, and macrophage infiltrates.Murine TRAMP-C1 were grown C57BL/6J mice 4 mm tumor diameter irradiated either 25 Gy a dose 60 15 fractions. Changes infiltrates assessed by immunohistochemistry molecular assays.Tumor growth was delayed for 1 week after both schedules. Tumor microvascular density (MVD)...
Cadmium (Cd) is hazardous to human health because of its toxicity and long half-life clearance. Many studies have explored the relationship between chronic Cd exposure different diseases. However, most limited study targets two or three organ systems. The goal this was establish a mouse model accumulation in systems particularly investigate potential toxic effects cardiovascular system. Mice were divided into groups: control group, Cd-100 Cd-200 group. In detected kidney, lung, liver, heart...
Symptomatic thoracic ossification of the ligamentum flavum (OLF) is rare, and its prognostic factors remain unclear. The authors retrospectively studied 24 patients with surgically treated OLF to delineate factor.The clinical manifestations, radiological studies, surgical records, pathological findings were reviewed. Preoperative postoperative neurological data reappraised using American Spinal Injury Association modified Japanese Orthopaedic (JOA) scoring systems. Spearman rank-correlation...
Abstract Purpose To assess the cerebrovascular responses to short breath holding of cerebral gliomas using blood oxygenation level‐dependent (BOLD) magnetic resonance imaging (MRI). Materials and Methods Six patients with a low‐grade glioma one patient high‐grade were studied T2*‐weighted echo planar (EPI) during repeated periods 15‐second or 20‐second breath‐holding. Tumor vascularity was evaluated dynamic susceptibility contrast perfusion MRI. Results Increases in BOLD signal intensity...
To compare the clinical outcomes of Taiwanese patients with ovarian clear cell carcinomas (CCCs) and serous (SCs). We retrieved records women epithelial cancer (Stage I–IV) who received primary surgeries between 2000 2013. Cancer-specific survival (CSS), progression-free survival, after recurrence (SAR) CCC SC were retrospectively compared. Multivariate analysis was used to identify independent predictors survival. Of 891 diagnosed cancer, 169 CCCs 351 high-grade SCs analyzed. The 5-year CSS...
Germline and somatic BRCA1/2 mutations define a subset of patients with ovarian cancer who may benefit from treatment poly (ADP-ribose) polymerase inhibitors. Unfortunately, data on the frequency germline in Taiwanese are scarce, prevalence being unknown. We aim to investigate occurrence 99 which included serous (n = 46), endometrioid 24), clear cell 29) carcinomas. were identified using next-generation sequencing formalin-fixed paraffin-embedded tumor samples. Pathogenic variants (BRCA1: n...
A case series of acute intermittent porphyria (AIP) is described that focuses on the clinical course disease with regard to neurological manifestations peripheral nervous system.Eight patients were diagnosed AIP basis characteristic findings, erythrocyte porphobilinogendeaminase activity, neuropathic patterns, serial changes in nerve conduction studies (NCS), and temporal relationship central system involvement.Six AIP<2 months after symptom onset had neuropathy was predominantly upper...
Overexpression of stress-induced phosphoprotein 1 (STIP1) - a co-chaperone heat shock protein (HSP) 70/HSP90 and activation the JAK2-STAT3 pathway occur in several tumors. Combined treatment with HSP90 inhibitor JAK2 exert synergistic anti-cancer effects. Here, we show that STIP1 stabilizes ovarian endometrial cancer cells. Knock-down endogenous decreased phospho-STAT3 levels. The N-terminal fragment interacts N-terminus JAK2, whereas C-terminal DP2 domain mediates interaction STAT3. A...
AbstractPurpose : To determine the contribution of intra-alveolar cells as opposed to fixed in interstitium development radiation-induced lung injury. Materials and methods C3H/HeN mice were irradiated thorax with various doses radiation. The cellular composition cytokine production assessed two sites by histological staining RNase protection assay. Results Following thoracic irradiation, there was an initial decrease number bronchial alveolar lavage (BAL) that followed after 2 months a...
In 1998, an outbreak of enterovirus 71-associated hand, foot, and mouth disease occurred in Taiwan. Pathologic studies two fatal cases with similar clinical features revealed different causative agents, emphasizing the need for postmortem examinations modern pathologic techniques investigation.
Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of carcinogenesis are essential. The aim this study was identify aberrantly expressed proteins in cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy used for screening candidate proteins. Immunoblotting immunohistochemical (IHC) analyses were performed confirm the results 2-DE, significance estimated....
Objectives: To determine the effects of albendazole on rabbits infected with larvae Angiostrongylus cantonensis by histopathological and magnetic resonance imaging (MRI) techniques.
Abstract Stress-induced phosphoprotein 1 (STIP1)—a co-chaperone of heat shock proteins—promotes cell proliferation and may act as an oncogenic factor. Similarly, glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation lysine-specific demethylase (LSD1)—an epigenetic regulator—can contribute to the development aggressive phenotype. Owing their ability tether different molecules into functional complexes, scaffold proteins have a key role in regulation signaling pathways...