A5052314950- Ultrasound and Hyperthermia Applications
- Glioma Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- Ultrasound Imaging and Elastography
- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Neurosurgical Procedures and Complications
- CNS Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Medical Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Immune cells in cancer
- Tryptophan and brain disorders
- Endoplasmic Reticulum Stress and Disease
- Ultrasound and Cavitation Phenomena
- Effects of Radiation Exposure
Chang Gung Memorial Hospital
2008-2024
Linkou Chang Gung Memorial Hospital
2013-2024
Keelung Chang Gung Memorial Hospital
2024
Chang Gung University
2010-2023
Taoyuan Chang Gung Memorial Hospital
2023
University of Minnesota
2017
University of Minnesota Medical Center
2014
Memorial Hospital
2012
National Cheng Kung University
2010
The purpose of this study is to assess the preclinical therapeutic efficacy magnetic resonance imaging (MRI)-monitored focused ultrasound (FUS)-induced blood-brain barrier (BBB) disruption enhance Temozolomide (TMZ) delivery for improving Glioblastoma Multiforme (GBM) treatment. MRI-monitored FUS with microbubbles was used transcranially disrupt BBB in brains Fisher rats implanted 9L glioma cells. FUS-BBB opening spectrophotometrically determined by leakage dyes into brain, and TMZ...
Focused ultrasound transiently opens the blood-brain barrier and provides potential to modulate tumor immunostimulatory effect.
Abstract Burst-mode focused ultrasound (FUS) induces microbubble cavitation in the vasculature and temporarily disrupts blood-brain barrier (BBB) to enable therapeutic agent delivery. However, it remains unclear whether FUS-induced BBB opening is accompanied by neuromodulation. Here we characterized functional effects of measuring changes somatosensory evoked potentials (SSEPs) blood-oxygen-level dependent (BOLD) responses. Rats underwent burst-mode FUS (mechanical index (MI) 0.3, 0.55 or...
An accurate method for neural stimulation within the brain could be very useful treating circuit dysfunctions and neurological disorders. With aim of developing such a method, this study investigated use piezoelectric molybdenum disulfide nanosheets (MoS2 NS) to remotely convert ultrasound energy into localized electrical in vitro vivo. The application cells surrounding MoS2 NS required only single pulse 2 MHz (400 kPa, 1,000,000 cycles, 500 ms duration) elicit significant responses 37.9 ±...
Malignant glioma is a common and severe primary brain tumor with high recurrence rate an extremely mortality within 2 years of diagnosis, even when surgical, radiological, chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because their adverse systemic effects poor blood–brain barrier penetration. Here, we combine methods to increase drug delivery tumors. Focused ultrasound transiently permeabilizes the barrier, increasing passive diffusion....
Abstract Focused ultrasound (FUS) with the presence of microbubbles induces blood brain barrier (BBB) opening in targeted areas and facilitates drug delivery. However, recent studies have indicated that FUS-BBB excessive exposure levels may be associated inflammatory response cellular/tissue damage. Multiple weekly FUS exposures been shown to safe for human subjects. However effect more frequent is still unknown. This study examines whether focused aggravated behavioral, histopathologic...
FUS-induced BBB opening is a promising technique for noninvasive and local delivery of drugs into the brain. Here we propose novel use neuronavigation system to guide procedure investigate its feasibility in vivo large animals.We developed an interface between neuronavigator FUS allow guidance focal energy produced by transducer. The was tested 29 swine more than 40 sonication procedures evaluated MR imaging. Gd-DTPA concentration quantitated imaging R1 relaxometry compared with ICP-OES...
Background. Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor. It a rapidly progressive, highly recurrent, fatal intracranial neoplasm, and demand for novel treatment urgent. Valproic acid (VPA) potential anticancer agent that belongs to class histone deacetylase (HDAC) inhibitors, targeting epigenetic control gene functions in cancer cells. This drug has been administered prevention or seizure disorder GBM patients; therefore, retrospective analysis may...
Abstract Background Glioblastoma multiforme (GBM) is the most aggressive type of glioma and carries poorest chances survival. There therefore an urgent need to understand mechanisms tumorigenesis develop or improve therapeutics. The aim this study was assess possible prognostic value cyclin-dependent kinase 6 (CDK6) effects microRNA-495 (miR-495) manipulation on CDK6 expression cell survival in cells. Methods Analyses clinical specimens from GBM patients were used. Expression analyzed by...
Glioblastoma (GBM), the most lethal type of brain tumor in adults, has considerable cellular heterogeneity. The standard adjuvant chemotherapeutic agent for GBM, temozolomide (TMZ), a modest response rate due to development drug resistance. Multiple studies have shown that valproic acid (VPA) can enhance GBM control and prolong survival when given conjunction with TMZ. However, beneficial effect is variable. In this study, we analyzed impact VPA on patient its possible correlation TMZ...
Ischemic stroke-reperfusion (S/R) injury is a crucial issue in the protection of brain function after thrombolysis. The vasodilation induced by ultrasound (US)-stimulated microbubble cavitation has been applied to reduce S/R through sonoperfusion. present study uses oxygen-loaded microbubbles (OMBs) with US stimulation provide sonoperfusion and local oxygen therapy for reduction infarct size neuroprotection S/R. murine model was established photodynamic thrombosis thrombolysis at remote...
Abstract Purpose: To verify that low‐frequency planar ultrasound can be used to disrupt the BBB in large animals, and usefulness of MRI quantitatively monitor delivery superparamagnetic iron oxide (SPIO) nanoparticles into disrupted regions. Materials Methods: Two groups swine subjected craniotomy were sonicated with burst lengths 30 or 100 ms, one group experiment was also performed confirm ability 28‐kHz sonication open transcranially. SPIO administered animals after disruption. Procedures...
BACKGROUND To clarify the clinical role of traumatic subarachnoid hemorrhage (tSAH), stratified analysis with grouping tSAH was performed. Their blood flow changes and correlations outcome were assayed. METHODS One hundred seventeen patients classified into several groups according to their initial computerized tomography scans. Group I included only in posterior interhemispheric fissure, whereas II contained located elsewhere. further subdivided IIa, little SAH; IIb, extensive IIc, SAH...
Colorectal cancer (CRC) is one of the most well-known malignancies with high prevalence and poor 5-year survival. Previous studies have demonstrated that a high-fat diet (HFD) capable increasing odds developing CRC. Acrolein, an IARC group 2A carcinogen, can be formed from carbohydrates, vegetable oils, animal fats, amino acids through Maillard reaction during preparation foods. Consequently, humans are at risk acrolein exposure consumption foods rich in fat. However, whether contributes to...
Oral squamous cell carcinoma (OSCC) accounts for 80–90% of all intraoral malignant neoplasms. The single greatest risk factor oral cancer is tobacco use, including cigarettes, cigars, chewing tobacco, and snuff. Aberrations the epidermal growth receptor (EGFR) pathway features prominently in tumorigenesis progression. It was shown that cigarette smoking (CS) associated with worse prognosis OSCC patients overexpression EGFR tumor tissue. However, mechanism by which induced activation remains...
Purpose. To evaluate the interactions of risk factors and identify their most powerful discrimination pathway for occurrence low back pain (LBP). Design. A cross-sectional study. Setting. Taiwan. Subjects. Taiwanese population 30 to 64 years old. Measures. self-reported question, “Have you experienced LBP within last 3 months?” was used LBP. The study variables included demographics (age, gender, occupation, education level, marital status, household income), biometric health measures (bone...