A5004537785- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Enzyme Catalysis and Immobilization
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Quantum Chromodynamics and Particle Interactions
- Hydrogels: synthesis, properties, applications
- Particle physics theoretical and experimental studies
- Tendon Structure and Treatment
- Nanoplatforms for cancer theranostics
- Silk-based biomaterials and applications
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Analytical Chemistry and Chromatography
- Cleft Lip and Palate Research
- Pancreatic function and diabetes
- Periodontal Regeneration and Treatments
- High-Energy Particle Collisions Research
- Protease and Inhibitor Mechanisms
- Protein purification and stability
- Craniofacial Disorders and Treatments
- Electrochemical sensors and biosensors
- Chemical and Physical Properties in Aqueous Solutions
- Atomic and Subatomic Physics Research
Chang Gung University
2016-2025
Chang Gung University of Science and Technology
2016-2025
Ming Chi University of Technology
2016-2025
Chang Gung Memorial Hospital
2016-2025
Linkou Chang Gung Memorial Hospital
2016-2024
Thomas Jefferson National Accelerator Facility
2010-2024
Shaoxing University
2021
Shaoxing People's Hospital
2021
Taipei Medical University Hospital
2019
Philippine General Hospital
2019
Abstract Summary: A thermo‐responsive comb‐like polymer with chitosan as the backbone and pendant poly( N ‐isopropylacrylamide) (PNIPAM) groups has been synthesized by grafting PNIPAM‐COOH a single carboxy end group onto through amide bond linkages. The copolymer exhibits reversible temperature‐responsive soluble‐insoluble characteristics lower critical solution temperature (LCST) being at around 30 °C. Results from SEM observations confirm porous 3D hydrogel structure interconnected pores...
We report on a high-statistics measurement of the deuteron spin structure function ${g}_{1}^{d}$ at beam energy 29 GeV in kinematic range $0.029<x<0.8$ and $1<{Q}^{2}<10$ (GeV $/c$${)}^{2}$. The integral ${\ensuremath{\gamma}}_{1}^{d}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}\ensuremath{\int}{1}^{}{g}_{1}^{d}\mathrm{dx}$ evaluated fixed ${Q}^{2}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}3$ $/c$${)}^{2}$ gives...
In this study, we have successfully fabricated electrospun bead-free silk fibroin [SF]/chitosan [CS] composite nanofibers [NFs] covering the whole range of CS content (0%, 25%, 50%, 75%, and 100%). SF/CS spinning solutions were prepared in a mixed solvent system trifluoroacetic acid [TFA] dichloromethane. The morphology NFs was observed by scanning electron microscope, average fiber diameter ranges from 215 to 478 nm. Confocal laser microscopy confirms uniform distribution SF within NFs. To...
Malignant glioma is a common and severe primary brain tumor with high recurrence rate an extremely mortality within 2 years of diagnosis, even when surgical, radiological, chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because their adverse systemic effects poor blood–brain barrier penetration. Here, we combine methods to increase drug delivery tumors. Focused ultrasound transiently permeabilizes the barrier, increasing passive diffusion....
By taking advantage of the pH-sensitive drug release property graphene oxide (GO) after intracellular uptake, we prepared folic acid (FA)-conjugated GO (GOFA) for targeted delivery chemotherapeutic doxorubicin (DOX). GOFA-DOX was further encapsulated in an injectable in-situ forming thermo-sensitive hyaluronic acid-chitosan-g-poly(N-isopropylacrylamide) (HACPN) hydrogel intratumoral DOX. As degradation time HACPN could be extended up to 3 weeks, GOFA-DOX/HACPN provide controlled and DOX...
The presence of both osteoconductive and osteoinductive factors is important in promoting stem cell differentiation toward the osteogenic lineage. In this study, we prepared silk fibroin/chitosan/nanohydroxyapatite/bone morphogenetic protein-2 (SF/CS/nHAP/BMP-2, SCHB2) nanofibrous membranes (NFMs) by incorporating BMP-2 core SF/CS/nHAP as shell layer a nanofiber with two different thicknesses (SCHB2-thick SCHB-thin). physicochemical properties SCHB2 were characterized compared those SF/CS...
In this study, we aimed to develop a multifunctional drug/gene delivery system for the treatment of glioblastoma multiforme by combining ligand-mediated active targeting and pH-triggered drug release features graphene oxide (GO). Toward end, load irinotecan (CPT-11) cetuximab (CET)-conjugated GO (GO-CET/CPT11) pH-responsive after endocytosis epidermal growth factor receptor (EGFR) over-expressed U87 human cells. The ultimate injectable was designed co-entrapping stomatin-like protein 2...