A5053783979- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Nanoparticle-Based Drug Delivery
- Head and Neck Surgical Oncology
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Folate and B Vitamins Research
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Renal function and acid-base balance
- Acute Kidney Injury Research
Chang Gung University
2010-2022
Chang Gung Memorial Hospital
2006-2022
Linkou Chang Gung Memorial Hospital
2013-2022
National Cheng Kung University
2010
National Taiwan University
2009
Memorial Hospital of South Bend
2009
Malignant glioma is a common and severe primary brain tumor with high recurrence rate an extremely mortality within 2 years of diagnosis, even when surgical, radiological, chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because their adverse systemic effects poor blood–brain barrier penetration. Here, we combine methods to increase drug delivery tumors. Focused ultrasound transiently permeabilizes the barrier, increasing passive diffusion....
Background Acute kidney injury (AKI) is a common event in the neonatal intensive care unit (NICU), especially extremely-low-birth-weight (ELBW) infants. This cohort study investigated incidence of and risk factors for AKI ELBW infants their overall survival at postmenstrual age (PMA) 36 weeks. Methods All admitted to our NICU between January 2010 December 2013 were enrolled. Those who died prior 72 hours life, had congenital renal abnormality, or only one datum serum creatinine (SCr) level...
Abstract Background Glioblastoma multiforme (GBM) is the most aggressive type of glioma and carries poorest chances survival. There therefore an urgent need to understand mechanisms tumorigenesis develop or improve therapeutics. The aim this study was assess possible prognostic value cyclin-dependent kinase 6 (CDK6) effects microRNA-495 (miR-495) manipulation on CDK6 expression cell survival in cells. Methods Analyses clinical specimens from GBM patients were used. Expression analyzed by...
The prognosis and recurrence rate after resection of an anterior skull base lesion via transciliary supraorbital keyhole craniotomy depend on residual tumor volume. extent to which pathology size influence the using this approach is unknown. Sixty-two patients underwent a total 64 operations in retrospective study. Meningioma was most common tumor, followed by pituitary adenoma craniopharyngioma. Age, sex, volume, operative duration, blood loss, complication rates were evaluated. Pre-...
Diverse treatment results are observed in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH). Significant initial perfusion compromise is thought to predict a worse outcome, but this has scant support the literature. In cohort study, authors correlate outcomes novel poor-outcome imaging predictor representing impaired cerebral on CT angiography (CTA).The reviewed of 148 aSAH treated at single tertiary referral center between 2007 and 2016. Patients "venous delay" phenomenon...
Delayed progressive mass effect (DPME) after securing an aneurysm is uncommon following microsurgical or endovascular repair and leads to a poor clinical outcome. Patients with ruptured middle cerebral artery (MCA) aneurysms have high risk of postoperative oedema effect, which may require decompressive treatment. Because few studies discussed the predictive factors, we focused on MCA evaluated outcomes these patients necessity salvage surgery when DPME presented.Data 891 aneurysmal...
Glioblastoma is the most common primary malignant brain tumor, and median survival relatively short despite aggressive standard treatment. Natural killer (NK) cell dysfunction strongly associated with tumor recurrence metastasis but unclear in glioblastoma. NK activity (NKA) represents cell-secreted interferon-γ (IFN-γ), which modulates immunity inhibits cancer progression. This study aimed to analyze NKA glioblastoma patients obtain a clearer overview of surveillance. From 2020 2021, total...
Tumor recurrence and malignant transformation (MT) are the main contributing factors of poor prognosis in treating diffuse infiltrative low grade gliomas (LGG). In current study, we conducted an integrated approach – transcriptomic analysis in-depth clinical molecular information to find susceptible genes associated with MT. MATERIALS AND From 2004 2015, a total 56 newly diagnosed World Health Organization (WHO) II LGG tumor samples were collected during surgical resection. All tissues...
Purpose: Recent studies showed that MRI can be safely performed on patients with deep brain stimulation (DBS) device in place when the stimulator is turned off. By interleaving DBS and echo‐planar imaging (EPI) acquisition, functional (fMRI) may a useful tool for understanding mechanism of as well helping localization electrodes. This study aimed to investigate possible false positive activations due limited time interval between end start EPI acquisition. Method Materials: The was using...