A5032022292- Andrographolide Research and Applications
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Inflammation biomarkers and pathways
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Genetic Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
Chung Shan Medical University
2015-2024
Chung Shan Medical University Hospital
2015-2024
China Medical University
2015
Chang Jung Christian University
2008-2010
Peking University
2004-2006
Peking University Third Hospital
2006
Ministry of Education of the People's Republic of China
2006
Northern California Institute for Research and Education
2005
Albert Einstein College of Medicine
1994
Montefiore Medical Center
1994
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus and also known as pseudocinnamomum or indigenous cinnamon. Its leaf traditionally used by local people in cooking folk therapy. We previously demonstrated the chemical composition anti-inflammatory effect of essential oil linalool chemotype streptozotocin-induced diabetic rats on endotoxin-injected mice. The aim present study evaluate whether cinnamaldehyde active compounds Kanehira. Before injection endotoxin,...
IARC has classified the betel nut as a human environmental carcinogen. Previous studies have found that arecoline (AR) is major alkaloid present in saliva of quid chewers. Saliva contains large content AR which been further shown to cause mutation oral mucosa cells, resulting cancer. Whereas, date, there are only few reported hepatotoxicity associated with and chewing. Therefore, main purpose this study was determine toxic effects its oxidative metabolite, N-oxide (ARNO), normal liver cell...
Andrographolide (1), an active constituent of Andrographis paniculata, decreased tumor necrosis factor-α (TNF-α)-induced intercellular adhesion molecule-1 (ICAM-1) expression and HL-60 cells onto human umbilical vein endothelial (HUVEC), which are associated with inflammatory diseases. Moreover, 1 abolished TNF-α-induced Akt phosphorylation. Transfection activated Akt1 cDNA vector increased phosphorylation ICAM-1 like TNF-α. In addition, LY294002 blocked IκB-α degradation nuclear p65 protein...
Matrix metalloproteinase-9 (MMP-9) plays a critical role in cancer metastasis. Andrographolide (AP) is diterpene lactone the leaves and stem of Andrographis paniculata (Burm. f) Ness that has been reported to possess anticancer activity. In this study, we investigated effect AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression invasion MCF-7 breast cells possible mechanisms involved. The results showed dose-dependently inhibited TPA-induced protein expression, enzyme...
Several lines of evidence indicate that inflammation and endothelial cell dysfunction are important initiating events in atherosclerosis. Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, induces the expression adhesion molecules results monocyte adherence atheromatous plaque formation. Andrographolide (AP) is major bioactive diterpene lactone Andrographis paniculata has anti-inflammatory activity. A previous study demonstrated role heme oxygenase 1 (HO-1) inhibition...
The essential oil from a lemongrass variety of Cymbopogon flexuosus [lemongrass (LO)] is used in various food and aroma industry products exhibits biological activities, such as anticancer antimicrobial activities. To investigate the effects 200 LO (200 mg/kg) 400 (400 its major component, citral (240 mg/kg), on drug-metabolizing enzymes, oxidative stress, acetaminophen toxicity liver, male Sprague-Dawley rats were fed pelleted diet administered or by gavage for 2 weeks. After weeks feeding,...
Cell migration plays an important role in angiogenesis and wound repair. Vascular endothelial growth factor (VEGF) is cell-specific mitogen that essential for cell survival, proliferation, migration. Docosahexaenoic acid (DHA), n-3 polyunsaturated fatty acid, shows both anti-inflammatory antioxidant activities vitro vivo. This study investigated the molecular mechanism by which DHA down-regulates VEGF-induced HUVECs were used as model, MTT assay, Western blot, wound-healing phosphatase...
Andrographolide is the most abundant terpenoid of A. paniculata which used in treatment diabetes. In this study, we investigated effects extract (APE) and andrographolide on expression drug-metabolizing enzymes rat liver determined whether modulation these changed pharmacokinetics tolbutamide. Rats were intragastrically dosed with 2 g/kg/day APE or 50 mg/kg/day for 5 days before a dose 20 mg/kg tolbutamide was given. reduced the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Carnosine is an endogenous dipeptide found in the vertebrate skeletal muscles that usually obtained through diet. To investigate mechanism by which carnosine regulates migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as experimental model this study. We examined cell migratory intravasive abilities expression epithelial-mesenchymal transition (EMT)-associated molecules matrix metalloproteinases (MMPs) after treatment. The results showed both...
Lipotoxicity leads to numerous metabolic disorders such as nonalcoholic steatohepatitis. Luteolin, apigenin, and chrysin are three flavones with known antioxidant anti-inflammatory properties, but whether they inhibit lipotoxicity-mediated NLRP3 inflammasome activation was unclear. To address this question, we used J774A.1 macrophages Kupffer cells stimulated 100 μM palmitate (PA) in the presence or absence of 20 each flavone. PA increased p-PERK, p-IRE1α, p-JNK1/2, CHOP, TXNIP well p62...
Spinocerebellar ataxia type 3 (SCA3), caused by the abnormal expansion of polyglutamine (polyQ) in ataxin-3 protein, is one inherited polyQ neurodegenerative diseases that share similar genetic and molecular features. Mutant polyQ-expanded protein prone to aggregation affected neurons predominantly degraded autophagy, which beneficial for disease treatment. Not only does mutant increase susceptibility oxidative cytotoxicity, but it also hampers antioxidant potency neuronal cells. Nuclear...