A5010342441- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Pelvic floor disorders treatments
- Diverticular Disease and Complications
- Cancer Diagnosis and Treatment
- Chemokine receptors and signaling
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal disorders and treatments
- Synthetic Organic Chemistry Methods
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple and Secondary Primary Cancers
- Pelvic and Acetabular Injuries
- Cytokine Signaling Pathways and Interactions
- Hernia repair and management
- Metastasis and carcinoma case studies
- Management of metastatic bone disease
- Cancer Research and Treatments
Chiayi Chang Gung Memorial Hospital
2012-2023
Chang Gung University
2009-2022
Chang Gung Memorial Hospital
2005-2019
Memorial Hospital of South Bend
2005-2015
Chang Gung University of Science and Technology
2010
Colon and Rectal Surgery Associates
2008
National Tsing Hua University
2000-2001
Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12)/CXC receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasis tumor cells to distant organs. In addition, resistin suggested be an important link between obesity development cancer. Resistin has identified as player inflammatory responses, emerged a mediator inflammation-associated A limited number studies have investigated association SDF-1 with Herein,...
The stress-upregulated catecholamines-activated β1- and β2-adrenergic receptors (β1/2-ARs) have been shown to accelerate the progression of cancers such as colorectal cancer (CRC). We investigated underlying mechanism inhibition β1/2-ARs signaling for treatment CRC elucidated significance β2-AR expression in vitro clinical samples. impacts β1/2-AR antagonists CRC-xenograft vivo were examined. found that repression but not β1-AR selectively suppressed cell viability, induced G1-phase cycle...
To our knowledge, stercoral perforation of the colon is rarely seen with fewer than 90 cases reported in literature till date.We explored principles management to prevent impending mortality five patients this condition.Five patients, two males and three females, whose median age was 64 years, had sustained sigmoid colon.Chronic constipation common symptom among these patients.Three underwent a Hartmann's procedure another were treated segmental colectomy anastomosis diverting...
Baicalein is the flavonoids with multiple pharmacological activities. The aim of our study was to investigate effects baicalein on colorectal cancer (CRC) and recognize targets treatment. To better understand baicalein's target, proteomic approaches were used purify identify protein substrates using 2D difference gel electrophoresis (2D SDS‐PAGE) elucidate proteins differential display. Results from this that treatment CRC cells results in reduced cell proliferation. As a result, displays...
Cigarette use is an independent risk factor for the development of erectile dysfunction (ED). While association between chronic smoking and ED well established, fundamental mechanism(s) cigarette-related are incompletely understood, partly due to no reliable animal model smoking-induced ED. The present study was designed validate in vivo rat cigarette-induced Forty 12-week old male Sprague-Dawley rats were divided into 4 groups. Ten served as control group exposed only room air. remaining 30...
Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities including vasodilatation, analgesia, anti-cardiovascular disease, anti-Alzheimer's anti-inflammation, and anti-tumor activity.This study analyzes the effects of evodiamine on cellular growth, tumorigenesis, cell cycle apoptosis induction human urothelial carcinoma (UCC) cells.The present showed that significantly inhibited proliferation UCC cells in a dose- time-dependent manner. Also,...
No AccessJournal of UrologyAdult Urology1 Aug 2015The Efficacy Postoperative Adjuvant Chemotherapy for Patients with pT3N0M0 Upper Tract Urothelial Carcinoma Yun-Ching Huang, Miao-Fen Chen, Chung-Sheng Shi, Alan W. Shindel, Cih-En See-Tong Pang, Cheng-Keng Chuang, Chih-Shou Ying-Hsu Chang, Wei-Yu Lin, Dong-Ru Ho, Chih-Chien Chin, Yi-Hung Kuo, and Ching-Fang Wu HuangYun-Ching Huang Division Urology, Department Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan Graduate Institute Clinical...
Abstract The stromal cell‐derived factor‐1 (SDF‐1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression. In addition, the protease urokinase‐type plasminogen activator (uPA) is an important factor tumor cell invasion and metastasis. However, mechanism by which SDF‐1 mediates uPA expression human cells remains unknown. We investigated molecular governing interaction between stimulation three colon lines (DLD‐1, SW48, COLO 205). found that led increase...
Whether some diseases are related to the occurrence of synchronous colorectal carcinoma (sCRC) is unknown. Investigating risk factors and presentation sCRC could aid in treatment patients with cancer (CRC). The prognosis compared that solitary CRC remains unclear.A total 17 093 were recruited between 1st January 1995 31th December 2016. development assessed using univariate multivariate logistic regression. effect on survival was analysed Cox regression model.The prevalence 5.6% this study....
To determine the effect of body mass index (BMI) on characteristics and overall outcome colon cancer in Taiwan.From January 1995 to July 2003, 2138 patients with were enrolled this study. BMI categories (in kg/m²) established according classification Department Health Taiwan. Postoperative morbidities mortality, survival analysis including (OS), disease-free (DFS), cancer-specific (CSS) compared across categories.There 164 (7.7%) underweight (BMI < 18.5 kg/m²), 1109 (51.9%) normal-weight =...
The CC chemokine receptor 6 (CCR6) and its ligand CCL20 are involved in human colorectal cancer (CRC) carcinogenesis can promote the progression of CRC. In addition, interleukin-17 (IL-17), produced by a T cell subset named "Th17," has been identified as an important player inflammatory responses, emerged mediator inflammation-associated cancer. However, relevance IL-17 development CRC still remains to be explored. This study aimed investigate effect on migration cells. Human HCT-116 cells...
A general method for total synthesis of natural trisubstituted γ-lactones is developed on the basis chemistry alkynyltungsten compounds. The key step in this approach involves cycloalkenation tungsten−η1-(3R,4S)-pent-1-yne-3,4-diol with aldehydes to give tungsten−oxacarbenium salts, further leading 3-alkylidene-4-hydroxy-5-methyl-γ-lactones upon demetalation. This synthetic sequence proceeds well alkynylaldehydes and MOM derivative tungsten−η1-(3R,4S)-pent-1-yne-3,4-diol. resulting...
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. The outcome CRC patients remains poor. Thus, new strategy for treatment urgently needed. Flavopereirine β-carboline alkaloid extracted from Geissospermum vellosii, which can reduce the viability various cells through an unknown mode action. aim present study was to investigate functional mechanism therapeutic potential flavopereirine on in vitro vivo. Our data showed that significantly lowered cellular...
aim:To analyze oncological outcome of intersphincteric resection (ISR) in ultra-low rectal cancer with intent to spare colostoma. mETHODS:From 1995 1998, patients a nonfixed adenocarcinoma (tumor stage T2) preserving the lower margin at 1-3 cm above dentate line without distant metastasis was enrolled (period I).ISR practiced eight patients, and their postoperative followup least 5 years.In addition, from 1999 2003, another 10 having same tumor location as period I underwent ISR II).Among...
The aim of the present study was to investigate whether unintentional body weight loss (BWL) provides additional clinical information in terms tumor progression and prognosis non‑metastatic colon cancer. In study, a total 2,406 consecutive cancer patients without metastasis were retrospectively enrolled. Unintentional BWL defined as >5% within last 6‑12 months, or subjectively upon fulfillment at least two following: Evidence change clothing size corroboration reported by family friend. This...