A5101569946- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Redox biology and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Protease and Inhibitor Mechanisms
Chiayi Chang Gung Memorial Hospital
2011-2024
Chang Gung University
2011-2024
Background/Aims: Colorectal cancer (CRC) is the third most common type of and second leading cause cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation apoptosis have diverse functions malignancy development. However, mechanism aberrant overexpression PRDX6 CRC remains unclear. Methods: Boyden chamber assay, flow cytometry a lentiviral shRNA targeting transient transfection with pCMV-6-PRDX6 plasmid were used to...
Abstract The stromal cell‐derived factor‐1 (SDF‐1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression. In addition, the protease urokinase‐type plasminogen activator (uPA) is an important factor tumor cell invasion and metastasis. However, mechanism by which SDF‐1 mediates uPA expression human cells remains unknown. We investigated molecular governing interaction between stimulation three colon lines (DLD‐1, SW48, COLO 205). found that led increase...
CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated molecular mechanisms by which mediated induction cell death, and performed cycle G2/M arrest to clarify changes in colorectal cancer cells (CRC). Treatment DLD-1 resulted triggering extrinsic apoptosis pathway through activation Fas-L,...
Colorectal cancer (CRC) is one of the leading causes mortality and 5-Fluorouracil (5-FU) most common chemotherapy agent CRC. A high level X-ray repair cross complementing group 1 (XRCC1) in cells has been associated with drug resistance occurrence. Moreover, activation adenosine monophosphate (AMP)-activated protein kinase (AMPK) indicated to regulate cell survival. Thus, this study was aimed examine whether XRCC1 plays a role 5-FU/AMPK agonist (AICAR)-induced cytotoxic effect on CRC...
Gastric cancer is the fourth most common and ranks as second leading cause of cancer-related deaths across world. The combination therapy surgery with chemotherapeutic drugs, that is, mitomycin C (MMC), becoming a major strategy for patients advanced gastric cancer. However, drug resistance factor limits effectiveness chemotherapy, which ultimately leads to failure chemotherapy. X-ray repair cross complementing group 1 (XRCC1), scaffold protein base excision process, has been implicated in...
Colorectal cancer (CRC) has become a prevalent and deadly malignancy over the years. Drug resistance remains major challenge in CRC treatment, significantly affecting patient survival rates. Obesity is key risk factor for development, accumulating evidence indicates that increased secretion of adipokines, including Visfatin, under obese conditions contributes to development various therapeutic methods. Amphiregulin (AREG) member epidermal growth (EGF) family, which activates EGF receptor...