In the past, very little research has been carried out into differing roles played by various quality attributes on customer satisfaction. addition, vast majority of scholars consider relationship between and satisfaction to be linear. However, from point view prospect theory, this may non-linear. This study begins reviewing past An investigative was then hypermarket customers it found that most is asymmetrical It also discovered value function curve theory can only used certain...

OBJECTIVE Disturbances in podocytes are typically associated with marked proteinuria, a hallmark of diabetic nephropathy. This study was conducted to investigate modulation Notch-1 signaling high glucose (HG)-stressed human and animal model. RESEARCH DESIGN AND METHODS Expression the Notch components examined HG-treated podocytes, embryonic kidney cells (HEK293), kidneys from animals by RT-qPCR, Western blot analysis, immunohistochemical staining. The association between signaling, VEGF...

This research examines empirically the relationship among social capital, entrepreneurial orientation, organizational resource, and performance for new ventures. Data is collected by means of mailing questionnaire to ventures in Taiwan, a total one hundred four qualified observations were collected. The results obtained this indicate that there are significant relationships resources. Additionally, influence resources on significant. BAI2006 ID=6030

Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12)/CXC receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasis tumor cells to distant organs. In addition, resistin suggested be an important link between obesity development cancer. Resistin has identified as player inflammatory responses, emerged a mediator inflammation-associated A limited number studies have investigated association SDF-1 with Herein,...

Evaluation of the protective effects curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model osteoarthritis Chih-Chang Yeh,1,2 Yu-Han Su,3 Yu-Jhe Lin,3 Pin-Jyun Chen,3 Chung-Sheng Shi,1 Cheng-Nan Chen,3,* Hsin-I Chang3,* 1Graduate Institute Clinical Medical Sciences, College Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic China; 2Orthopaedic Department, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, 3Department...

Vascular calcification is the major reason for high mortality of cardiovascular complications diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evidence have not clearly identified. Hence, study was aimed to investigate whether concentration glucose (HG), which mimics hyperglycemia environment, could initiate vascular through NLRP3/IL-1β inflammasome underlying mechanism. Recently, 6-shogaol, a ginger derivate, elucidated pharmaceutic...

The drug resistance of colorectal cancer (CRC) cells against 5-fluorouracil (5-FU) therapy is a major challenge to successful treatment. While previous studies have proposed several 5-FU mechanisms, the effects adipokines on remain unclear. Thus, this study investigated effect resistin 5-FU-treated CRC cell lines. upregulation NLRP3 can regulate inflammatory responses in and then enhance progression. This expression level function 5-FU-induced cytotoxicity found that resistin-induced ERK...

Although the applications of grey system theory have been prosperous in engineering field, there are very few to management field. We argue that this is worthy promotion Therefore, main purpose study demonstrate application relation analysis, one part theory, by analyzing topic service quality and customer satisfaction. Customers auto repair industry were chosen find out order Parasuraman et al .’s ten factors. Tries prove whether or not satisfaction two different constructs. Finally, tries...

In recent years, green energy has undergone a lot of development and been the subject many applications. Many research studies have focused on illumination with sunlight as means saving creating healthy lighting. Natural light systems collecting, transmitting, lighting elements. Today, most daylight collectors use dynamic concentrators; these include Sun tracking systems. However, this design is too expensive to be cost effective. To create low-cost collector that can easily installed large...

Abstract The mechanism of homocysteine‐induced cell proliferation in human vascular smooth muscle cells (SMCs) remains unclear. We investigated the molecular mechanisms by which homocysteine affects expression cyclins A and D1 umbilical artery SMCs (HUASMCs). Homocysteine treatment induced HUASMCs increased levels D1. Knocking down either cyclin or small interfering RNA (siRNA) inhibited proliferation. Furthermore, with extracellular signal‐related kinase (ERK) inhibitor (PD98059) dominant...

Obesity has been shown to be associated with the risk of colorectal cancer (CRC). Adipokines produced by adipose tissue are linked some malignancies, including CRC. Visfatin is an adipokine a biomarker CRC malignant potential. In addition, stromal cell-derived factor-1 (SDF-1) reported play role in progression. Although relationship between visfatin and established, underlying mechanism not clarified. We investigated molecular governing interaction stimulation SDF-1 expression human cell...

Biodegradable polymers, such as polycaprolactone (PCL), have been well studied in the application of tissue engineering and drug delivery systems due to their favourable biocompatibility profiles. However, little research has discussed influence molecular weight these polymers on cell behaviours. Here, PCL films were synthesized using with various physical characteristics effect growth evaluated. Results showed that tensile strength elongation rate increased from 1.82 MPa 95.3% 2.01 741.6%...

Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro vivo bioactivity CAPE addressed role p53 p38 mitogen-activated protein kinase (MAPK) pathway regulating CAPE-induced apoptosis C6 glioma cells.C6 cancer cell lines were exposed doses CAPE; DNA fragmentation MAPKs NGF/P75NTR levels then determined. SMase activity ceramide content...

Purpose The purpose of this paper is, first, to provide a comprehensive discussion about entrepreneur opportunism's antecedents (uncertainty, information asymmetry, asset specificity and relational exchange) consequences (transaction cost, trust, commitment, performance, cooperation) and, second, construct model by linking entrepreneurs' opportunism its consequences. Design/methodology/approach tests the theoretical construction empirically. In total, 200 retailers computer industry in...

The CC chemokine receptor 6 (CCR6) and its ligand CCL20 are involved in human colorectal cancer (CRC) carcinogenesis can promote the progression of CRC. In addition, interleukin-17 (IL-17), produced by a T cell subset named "Th17," has been identified as an important player inflammatory responses, emerged mediator inflammation-associated cancer. However, relevance IL-17 development CRC still remains to be explored. This study aimed investigate effect on migration cells. Human HCT-116 cells...

Homocysteine and pro-inflammatory mediators such as cyclooxygenase-2 (COX-2) have been linked to vascular dysfunction risks of cardiovascular diseases. Fulvic acid (FA), a class compounds humic substances, possesses various pharmacological properties. However, the effect FA on inflammatory responses monocytes remains unclear. We investigated regulatory homocysteine-induced COX-2 expression in human monocytes.Peripheral blood U937 cells were used for all experiments. Real-time PCR ELISA assay...

Abstract Bacterial adherence to epithelial cells is a key virulence trait of pathogenic bacteria. The type 1 fimbriae and the P-fimbriae uropathogenic Escherichia coli (UPEC) have both been described be important for establishment urinary tract infections (UTI). To explore interactions between host bacterium responsible different environments UPEC invasion, we examined effect pH osmolarity on strain J96 fimbrial expression, subsequent J96-induced interleukin-8 (IL-8) expression in...

Abstract Objective To test a fluid flow system for the investigation of influence shear stress on expression plasminogen activator inhibitor 1 (PAI‐1) in human osteoarthritic (OA) articular chondrocytes (from lesional and nonlesional sites) SW‐1353 chondrocytes. Methods Human OA normal were cultured type II collagen–coated glass plates under static conditions or placed chamber to form closed fluid‐circulation exposure different levels (2–20 dyn/cm 2 ). Real‐time polymerase chain reaction was...

Abstract Background The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis can promote the progression of CRC. Interaction between CRC cells endothelium a key event tumor progression. aim this study was to investigate effect SDF-1 on adhesion cells. Methods Human DLD-1 were used intercellular molecule-1 (ICAM-1) expression cell endothelium. Results treatment induced increased level...

Synovial macrophages, which can release proinflammatory factors, are responsible for the upregulation of cartilage-breakdown proteases and play critical roles in cartilage degradation during progression osteoarthritis (OA). In addition, shear stress exerts multifunctional effects on chondrocytes by inducing synthesis catabolic or anabolic genes. However, interplay chondrocytes, regulation function remains poorly understood. We investigated mechanisms underlying modulation human chondrocyte...

Background Beclin 1 and 2 are autophagy-related proteins that show similar amino acid sequences domain structures. established the first connection between autophagy cancer. However, role of in cancer is unclear. The aims this study were to analyze expressions oral tissues cell lines, evaluate their possible roles progression. Methods We investigated by immunohistochemistry 195 cases prognostic analyzed statistically. In vitro, overexpression knockdown performed on an line, SAS....

Even though nowadays entrepreneurship is a universal concept, there are still some gaps between understanding entrepreneurs and entrepreneurship, specifically in developing countries like El Salvador; which the smallest most densely populated country Central America. The purpose of this paper to fill gap provide solutions suggestions for business administration students people interested becoming future entrepreneurs. factors related intentions starting new Salvador main problem country....

Breast neoplasms are the most common cancer among women in Taiwan. Cognitive deficits complications of breast survivors treated with chemotherapy. The frequently observed disorders involve executive function and memory impairment. With improvements tumor intervention consequent increase number survivors, quality life patients has become an important issue. We interested early effects chemotherapy on brain structures patients. In addition, generalized q-sampling imaging (GQI), a wide range...

A high level of serum resistin has recently been found in patients with a number cancers, including colorectal cancer (CRC). Hence, may play role CRC development. Fulvic acid (FA), class humic substances, possesses pharmacological properties. However, the effect FA on pathophysiology remains unclear. The aim this study was to investigate endothelial adhesion and determine whether elicits an antagonistic mechanism neutralize effect. Human HCT-116 (p53-negative) SW-48 (p53-positive) cells...