A5037919538- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- biodegradable polymer synthesis and properties
- Meteorological Phenomena and Simulations
- Lipid Membrane Structure and Behavior
- Spine and Intervertebral Disc Pathology
- Climate variability and models
- Bone Metabolism and Diseases
- 3D Printing in Biomedical Research
- Skin Protection and Aging
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Bone health and treatments
- Silk-based biomaterials and applications
- Antioxidant Activity and Oxidative Stress
National Chiayi University
2013-2024
University of Arizona
2022-2024
National Kaohsiung Normal University
2020
National Yang Ming Chiao Tung University
2019
The University of Sydney
2004-2010
The University of Queensland
2010
Aston University
2005
Abstract The antibiotic, gentamicin sulphate (GS), was incorporated in gravity‐spun polycaprolactone (PCL) fibers by spinning from particulate suspensions of the drug PCL solution to produce a controlled delivery system. production rate GS‐loaded confined range 1–1.5 m/min and fiber diameter 170–220 μm. kinetics release could be adjusted varying GS loading suspension preparation conditions. Gradual ∼80% initial content measured phosphate buffered saline at 37°C over 50 days spun...
Abstract The mechanism of homocysteine‐induced cell proliferation in human vascular smooth muscle cells (SMCs) remains unclear. We investigated the molecular mechanisms by which homocysteine affects expression cyclins A and D1 umbilical artery SMCs (HUASMCs). Homocysteine treatment induced HUASMCs increased levels D1. Knocking down either cyclin or small interfering RNA (siRNA) inhibited proliferation. Furthermore, with extracellular signal‐related kinase (ERK) inhibitor (PD98059) dominant...
Background A tissue-engineered skin substitute, based on gelatin (“G”), collagen (“C”), and poly(ε-caprolactone) (PCL; “P”), was developed. Method G/C/P biocomposites were fabricated by impregnation of lyophilized gelatin/collagen (GC) mats with PCL solutions, followed solvent evaporation. Two different GC:PCL ratios (1:8 1:20) used. Results Differential scanning calorimetry revealed that all had characteristic melting point at around 60 °C. Scanning electron microscopy showed similar...
Biodegradable polymers, such as polycaprolactone (PCL), have been well studied in the application of tissue engineering and drug delivery systems due to their favourable biocompatibility profiles. However, little research has discussed influence molecular weight these polymers on cell behaviours. Here, PCL films were synthesized using with various physical characteristics effect growth evaluated. Results showed that tensile strength elongation rate increased from 1.82 MPa 95.3% 2.01 741.6%...
We assessed and quantified future projected changes in terrestrial evaporative demand by calculating Potential Evapotranspiration (PET) for the North American Monsoon region Southwestern U.S. Mexico. The PET projections were calculated using daily Penman–Monteith equation. meteorological variables needed equation (i.e., minimum maximum temperature, specific humidity, wind speed, incoming shortwave radiation, pressure) obtained from American–CORDEX initiative. used dynamically downscaled of...
Abstract Objective To test a fluid flow system for the investigation of influence shear stress on expression plasminogen activator inhibitor 1 (PAI‐1) in human osteoarthritic (OA) articular chondrocytes (from lesional and nonlesional sites) SW‐1353 chondrocytes. Methods Human OA normal were cultured type II collagen–coated glass plates under static conditions or placed chamber to form closed fluid‐circulation exposure different levels (2–20 dyn/cm 2 ). Real‐time polymerase chain reaction was...
aqueous or lipid phases of liposomes with various sizes, compositions and other characteristics by different preparation techniques.An ideal method liposome formulation is preparing high entrapment efficiency, narrow particle size distribution long term stability.Numbers techniques have been reported for such as Bangham method, the detergent depletion ether/ethanol injection reverse phase evaporation emulsion [48].The majority methods require using organic solvents to dissolve lipids but...
Synovial macrophages, which can release proinflammatory factors, are responsible for the upregulation of cartilage-breakdown proteases and play critical roles in cartilage degradation during progression osteoarthritis (OA). In addition, shear stress exerts multifunctional effects on chondrocytes by inducing synthesis catabolic or anabolic genes. However, interplay chondrocytes, regulation function remains poorly understood. We investigated mechanisms underlying modulation human chondrocyte...
Skin substitutes with existing vascularization are in great demand for the repair of full-thickness skin defects. In present study, we hypothesized that a pre-vascularized substitute can potentially promote wound healing. Novel three-dimensional (3D) were prepared by seeding mixture human endothelial progenitor cells (EPCs) and fibroblasts into plasma/calcium chloride formed gel scaffold, keratinocytes onto surface plasma gel. The capacity EPCs to differentiate vascular-like tubular...
Ginger extracts have been shown to health-promoting pharmacological activity and beneficial effects, including antioxidant anticancer properties. The extraction of ginger by natural deep eutectic solvents (NaDES) has enhance bioactivity, but the cytotoxicity NaDES needs be further determined. Signaling through CXC chemokine receptor 4 (CXCR4) expressed on colorectal cancer (CRC) cells a pivotal role in tumor cell chemosensitivity. Oxaliplatin is third-generation platinum compound used as an...
Excessive mechanical loading is a major cause of spinal degeneration, typically originating from tear in the annulus fibrosus (AF). Endoplasmic reticulum (ER) stress and NLRP3 (NOD-, LRR- pyrin domain-containing protein 3) inflammasome have been implicated pathogenesis intervertebral disc (IVD) degeneration. However, causal relationship between stretching AF cells response associated with ER remains scarce. To elucidate regulatory mechanisms stretch-induced IVD human cell lines were...
Osteoarthritis (OA) is currently still an irreversible degenerative disease of the articular cartilage. Recent, dextrose ( d ‐glucose) intraarticular injection prolotherapy for OA patients has been reported to benefit chondrogenic stimulation damaged However, detailed mechanism glucose's effect on cartilage repair remains unclear. Chitosan, a naturally derived polysaccharide, recently investigated as surgical or dental dressing control breeding. Therefore, in this study, glucose was adsorbed...
The dermis of human skin contains large numbers fibroblasts that are responsible for the production extracellular matrix (ECM) supporting integrity, elasticity and wound healing. Previously, an in vivo study demonstrated dermal siting lower capable to convert into adipose layer hence fibroblast lipogenesis may vary structure dermis. In present study, Hs68 were utilized as vitro model via using adipogenic differentiation medium (ADM). Baicalein, isolated from Scutellaria baicaleinsis, is one...
The shear force effect on human chondrocytes is time and magnitude dependent. Recently, kruppel‐like factor (KLF) 4 has been identified as a pleiotropic protein its activity in cells dependent different stimuli and/or cell types. role of KLF4 still unclear there no report determining whether regulates levels chondrocytes. Hence, this study was carried out to investigate the under stimulation underlying mechanism. Human primary SW1353 were used study. forces at 2, 5, or 15 dyn/cm 2 intensity...
Abstract Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Chemotherapy has been major strategy for treating patients with advanced CRC. Oxaliplatin (OXA) used as both an adjuvant and neoadjuvant anticancer agent available to treat High‐mobility group box 1 protein (HMGB1) a critical regulator cell survival. HMGB1 overexpression shown be resistant cytotoxic agents. In addition, Metformin, widely drug diabetes, emerged potential agent. this study, we examined whether...