Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim this study was investigate whether H. erinaceus mycelium could act as anti-inflammatory agent bring about neuroprotection using a model global ischemic stroke and mechanisms involved. Rats were treated with its isolated diterpenoid derivative, erinacine A, after ischemia reperfusion brain injuries caused by occlusion two common carotid arteries. production...

Toll-like receptors (TLRs) not only form an important part of the innate immune system but also serve to activate adaptive in response cancer. Real-time PCR; immunohistochemical stain and Western blotting analyses were performed clarify molecular alterations colorectal cancer (CRC) patients. We identified receptor 1 (TLR1), TLR2, TLR4 TLR8 gene expression levels downstream gene, i.e., interleukin-6 (IL-6), IL-8, interferon-α (IFN-α) myeloid differentiation primary-response protein-88...

Abstract Background Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration H. mycelium (HEM) and isolated diterpenoid derivative, erinacine A, can act as anti-neuroinflammatory agent bring about neuroprotection using MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model Parkinson’s disease, results in motor disturbances, addition elucidating the mechanisms...

The aim of this study was to evaluate the benefit adding hypoalbuminemia American College Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) Risk Calculator when predicting postoperative outcomes in colorectal cancer patients. ACS-NSQIP offers qualified risk evaluation surgical decision-making and informed patient consent. To date, malnutrition defined as hypoalbuminemia, an important independent factor cancer, is not included. This a retrospective, multi-institutional...

The red blood cell distribution width (RDW) is a simple and widely available parameter obtained from complete count test usually used in the analysis of anemia. Recently, studies have discovered association between RDW host inflammatory response cancer patients. We aimed to determine prognostic value colorectal (CRC) 5315 total patients with stage I-II CRC Chang Gung Memorial Hospital 2001 2018 were enrolled. study cohort was divided into two groups using = 13.8 as cutoff determined by...

Background/Aims: Colorectal cancer (CRC) is the third most common type of and second leading cause cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation apoptosis have diverse functions malignancy development. However, mechanism aberrant overexpression PRDX6 CRC remains unclear. Methods: Boyden chamber assay, flow cytometry a lentiviral shRNA targeting transient transfection with pCMV-6-PRDX6 plasmid were used to...

Hericium erinaceus, a valuable pharmaceutical and edible mushroom, contains potent bioactive compounds such as H. erinaceus mycelium (HEM) its derived ethanol extraction of erinacine A, which have been found to regulate physiological functions in our previous study. However, HEM or A with post-treatment regimens also shows effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, but mechanisms remain unknown. By using annexin-V–fluorescein-isothiocyanate...

The drug resistance of colorectal cancer (CRC) cells against 5-fluorouracil (5-FU) therapy is a major challenge to successful treatment. While previous studies have proposed several 5-FU mechanisms, the effects adipokines on remain unclear. Thus, this study investigated effect resistin 5-FU-treated CRC cell lines. upregulation NLRP3 can regulate inflammatory responses in and then enhance progression. This expression level function 5-FU-induced cytotoxicity found that resistin-induced ERK...

Hericium erinaceus, a consumable mushroom, has shown potential to enhance the production of neuroprotective bioactive metabolites. Traumatic brain injury (TBI) often leads cognitive, physical, and psychosocial impairments, resulting in neuroinflammation loss cortical neurons. In this research, effects H. erinaceus mycelium, its derivative erinacine C, along with underlying mechanisms, were examined terms oxidative stress modulation neurological improvement rat model mild traumatic (mTBI)....

Background / Aims: Erinacine A, isolated from the ethanol extract of Hericium erinaceus mycelium, has been demonstrated as a new alternative anticancer medicine. Drawing upon current research, this study presents an investigation molecular mechanism erinacine A inhibition associated with gastric cancer cell growth. Methods: Cell viability was determined by Annexin V–FITC/propidium iodide staining and migration using Boyden chamber assay to determine effects treatment on proliferation...

Erinacine A, a major active component of diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation the molecular mechanism erinacine A induction associated with cancer cells' aggressive status and death. proteomic approach was used purify identify differentially expressed proteins following treatment its action in apoptotic targets A. Our results demonstrate that HCT-116 DLD-1 cells increased cell...

A combination of fluorescence two-dimensional difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization time flight mass spectrometry approach was used to search for potential markers prognosis intervention colorectal cancer (CRC) at different stages lymph node metastasis (LMN). This quantitative proteomic survey aimed investigate the LNM-associated proteins evaluate clinicopathological characteristics these target in CRC from stage I IV.Sixteen cases were...

CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated molecular mechanisms by which mediated induction cell death, and performed cycle G2/M arrest to clarify changes in colorectal cancer cells (CRC). Treatment DLD-1 resulted triggering extrinsic apoptosis pathway through activation Fas-L,...

Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia H. erinaceus, displays great antitumorigenic activity. However, molecular mechanisms underlying erinacine A inducing cancer cell apoptosis in colorectal (CRC) remain unclear. This study found that treatment with not only triggers activation extrinsic pathways (TNFR, Fas, FasL, and caspases) but also suppresses expression antiapoptotic molecules Bcl-2 Bcl-XL via a time-dependent manner DLD-1...

The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis plays an important role in tumor angiogenesis and invasiveness colorectal cancer (CRC) progression. In addition, metastatic CRC remains one of the most difficult human malignancies to treat because its chemoresistant behavior. However, mechanism by which correlation occurs between CXCR4 clinical response chemotherapy unknown. We generated cells with increasing doses oxaliplatin (OXA) 5-Fluorouracil (5FU) develop resistance...

Colorectal cancer is the third leading cause of death worldwide. Currently, novel chemotherapeutic agents are first-line therapy for unresectable stage IV colorectal cancer, while benefits noncurative primary tumor resection in advanced disease remain debatable.This meta-analysis evaluated outcomes patients with receiving systemic chemotherapy or without resection.A database search PubMed and Cochrane Library databases identified 167 studies that were screened relevance. After 119 excluded,...

Ailanthoidol (ATD) has been isolated from the barks of Zanthoxylum ailanthoides and displays anti-inflammatory, antioxidant, antiadipogenic, antitumor promotion activities. Recently, we found that ATD suppressed TGF-β1-induced migration invasion HepG2 cells. In this report, exhibited more potent cytotoxicity in Huh7 hepatoma cells (mutant p53: Y220C) than (wild-type p53). A trypan blue dye exclusion assay colony showed inhibited growth also induced G1 arrest reduced expression cyclin D1...

To determine the clinical manifestations and optimal management of female patients with advanced colorectal cancer (CRC) metastasis in ovaries mimicking ovarian malignancy.A retrospective medical records review primary CRC to ovaries, which were initially diagnosed as malignancy, treated between 2001 2013. Clinical presentations, pathologic findings, treatment outcomes analyzed.In total, 19 cases collected study through a hospital tumor registry. The mean age at time diagnosis was 45 years...

A high level of serum resistin has recently been found in patients with a number cancers, including colorectal cancer (CRC). Hence, may play role CRC development. Fulvic acid (FA), class humic substances, possesses pharmacological properties. However, the effect FA on pathophysiology remains unclear. The aim this study was to investigate endothelial adhesion and determine whether elicits an antagonistic mechanism neutralize effect. Human HCT-116 (p53-negative) SW-48 (p53-positive) cells...

Osteoarthritis (OA) is currently still an irreversible degenerative disease of the articular cartilage. Recent, dextrose ( d ‐glucose) intraarticular injection prolotherapy for OA patients has been reported to benefit chondrogenic stimulation damaged However, detailed mechanism glucose's effect on cartilage repair remains unclear. Chitosan, a naturally derived polysaccharide, recently investigated as surgical or dental dressing control breeding. Therefore, in this study, glucose was adsorbed...

Abstract The prognostic significance of sarcopenia has been widely studied in different cancer patients. This study aimed to analyze the influence on long-term survival patients with colorectal liver metastasis (CRLM) undergoing hepatic resection. A retrospective analysis 182 resection for CRLM was performed. Sarcopenia determinedusing Hounsfield unit average calculation (HUAC), a measure muscle quality-muscledensity at preoperative abdominal computed tomography scans. defined as an HUAC...

Erinacine S, the new bioactive diterpenoid compound isolated from ethanol extract of mycelia <italic>Hericium erinaceus</italic>, displays great health-promoting properties.