A5029433338- Virus-based gene therapy research
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Hemophilia Treatment and Research
- Cellular transport and secretion
- CRISPR and Genetic Engineering
- Adenosine and Purinergic Signaling
- Urinary Bladder and Prostate Research
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- HIV Research and Treatment
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Lipid metabolism and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Sexual function and dysfunction studies
National Taiwan University Hospital
2011-2022
University of Electronic Science and Technology of China
2021-2022
Shenzhen Genoimmune Medical Institute
2019-2022
National Health Research Institutes
2008-2018
National Taiwan University
2011
University of Michigan
2000
The progress of using gadolinium (Gd)-based nanoparticles in cellular tracking lags behind that superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI). Here, dual functional Gd-fluorescein isothiocyanate mesoporous silica (Gd-Dye@MSN) possess green fluorescence and paramagnetism are developed order to evaluate their potential as effective T1-enhancing trackers for human mesenchymal stem cells (hMSCs). hMSCs labeled efficiently with Gd-Dye@MSN via endocytosis. Labeled unaffected...
Parkinson's disease (PD) is a prevalent neurodegenerative characterized by the loss of dopaminergic (DA) neurons. With their migration capacity toward sites diseased DA neurons in PD brain, mesenchymal stem cells (MSCs) have potential to differentiate for replacement damaged and secrete neurotrophic factors protection regeneration neurons; therefore MSCs show promise treatment PD. In this study, first time, we demonstrate that dextran-coated iron oxide nanoparticles (Dex-IO NPs) can improve...
Superparamagnetic iron oxide (SPIO) nanoparticles show promise as labels for cellular magnetic resonance imaging (MRI) in the application of stem cell-based therapy. However, unaddressed concerns about impact SPIO on cell attributes make feasibility labeling uncertain. Here, we that human mesenchymal cells (hMSCs) with ferucarbotran can induce epidermal growth factor receptor (EGFR) overexpression. Labeled hMSCs their overexpressed EGFR were attracted by tumorous EGF and more effectively...
dex-IO NPs can activate the antitumor mechanism (tumor tropism) but inactivate protumor mechanisms to transform MSCs (pT-MSCs) into (aT-MSCs).
In ferucarbotran-labeled hMSCs, the internalized EGFRs are mostly redirected from late endosomes/lysosomes to recycling endosomes, which protects lysosomal degradation of EGFR and results in cellular (membranous) exosomal overexpression.
Hemophilia A (HA) is a bleeding disorder caused by deficiency of the coagulation factor VIII (F8). F8 replacement standard care, whereas gene therapy (F8 gene) for HA an attractive investigational approach. However, large size and immunogenicity product present challenges in development therapy. To resolve these problems, we synthesized shortened (F8-BDD) cloned it into lentiviral vector (LV). The F8-BDD produced mainly short cleaved inactive products LV-transduced cells. improve...
Abstract Loss of adipose tissue, primarily due to increased lipolysis but also an impairment adipogenesis, is a key feature weight loss in cancer cachexia. Because the myriad pathogenic signaling pathways essential for atrophy effective therapeutic agents cachectic are lacking and urgently needed. The authors evaluated effects YC‐1 on adipogenesis 3T3‐L1 preadipocytes, TNF‐α‐ tumor‐cell‐induced adipocytes, colon‐26 adenocarcinoma‐bearing mice because has been shown possess versatile...