A5061747988- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Welding Techniques and Residual Stresses
- Bone Metabolism and Diseases
- Adsorption and Cooling Systems
- IL-33, ST2, and ILC Pathways
- Cancer-related gene regulation
- Pain Management and Opioid Use
- Dynamics and Control of Mechanical Systems
- Pressure Ulcer Prevention and Management
- Intravenous Infusion Technology and Safety
- Vibration and Dynamic Analysis
- High-Temperature Coating Behaviors
- Lipid metabolism and disorders
- Nosocomial Infections in ICU
- Solidification and crystal growth phenomena
- Advanced Welding Techniques Analysis
- Bone health and treatments
Shanghai Center For Bioinformation Technology
2024-2025
Beijing Institute of Genomics
2024-2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2024-2025
Shihezi University
2018-2024
Zhongshan People's Hospital
2023-2024
Wuhan National Laboratory for Optoelectronics
2022
Huazhong University of Science and Technology
2022
Tianjin Medical University
2021
Beihang University
2013
Abstract Tumor cells evolve strong antioxidant capacities to counteract the abnormal high level of reactive oxygen species (ROS) in tumor microenvironment. Glutamate-cysteine ligase catalyzing subunit (GCLC) for synthesis glutathione (GSH) represents key enzyme maintain redox homeostasis cells, however, whether its activity is regulated by posttranslational modifications, such as succinylation, remains be clarified. Here, we demonstrate existence succinylation modification on GCLC vitro and...
To investigate the role and possible molecular mechanism of Krüppel-like factor 7 (KLF7) in TLR4/NF-κB/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA).The mRNA protein expression levels KLF7 factors signal pathways were detected qRT-PCR Western blotting after cell culture with different concentrations palmitic acid (PA). The or TLR4 adipocytes was upregulated downregulated; that, these key detected. downregulated while PA stimulated adipocytes, then expressions...
As one of the most common forms cancer that threatens men's health, prostate (PCa) is under a trend increasing morbidity and mortality in countries. More more studies have pointed out obesity closely linked to occurrence development PCa, although there are still many undiscovered molecular mechanisms between two.In present study, we compare serum lipid levels patients with PCa normal individuals. cells (PC3 22RV1) were cultured vitro, TC/TG/HDL/GLU assay kit was used detect glucose...
Abstract Background Obesity-induced abnormal bone marrow microenvironment is one of the important risk element for metastasis in prostate cancer (PCa). The present study aimed to determine whether obesity-induced elevation palmitic acid (PA), which most abundant free fatty acids (FFAs), increased CCL2 via GPRs/KLF7 pathway adipocytes (BMA) facilitate PCa growth and metastasis. Methods We constructed a bone-tumor bearing mouse model with obesity through high-fat diet, observed tumor formation...
RNA binding protein RBM10 participates in various metabolism, and its decreased expression or loss of function by mutation has been identified many human cancers. However, how dysregulation contributes to cancer pathogenesis remains be determined. Here, we found that was breast tumors, patients with low presented poorer survival rates. depletion cells significantly promotes the cellular proliferation migration. We further demonstrated forms a triple complex YBX1 phosphatase 1B (PPM1B), which...
Abstract Aims Establishing a nomogram to estimate the probability of oral mucosal membrane pressure injury endotracheal tube‐intubated hospitalized patients in intensive care unit. Design Multicentre prospective cohort study. Methods Using Lasso regression and COX regression, variable selection was performed on demographic, clinical laboratory data 1037 ICU from West China Hospital, construct nomogram. External validation conducted 484 People's Hospital Zhongjiang County. Results Among 38...
Abstract Background Han and Uygur are the two main nationalities living in Xinjiang, China. There significant differences incidence of metabolic diseases for nationalities, but specific reasons not clear. Obesity is an important risk factor development syndrome, which may be closely related to increase serum free fatty acids (FFAs) content. This study aims use metabolomics compare changes FFAs profiles between normal weight (NW) obese (OB) individuals screening out differential FFAs,...
Bone cancer pain is characterized by moderate to severe ongoing that commonly requires the use of opiates, which could produce tolerance or addiction. Baicalin a flavonoid compound extracted from Huang Qin, possesses antioxidant properties, and has an analgesic effect on nitroglycerin-induced migraine in rats neuropathic spinal nerve ligation rats. However, baicalin bone still unclear. Therefore, aim this study examine rat model pain. animal was created tumor cell implantation (TCI). Animal...
When performing operation tasks, the interaction between a flexible manipulator and grasped object usually results in an impact. In this paper, new way is suggested to alleviate impact vibration of via its structural characteristic when capturing moving object. Controllable local degrees freedom are introduced topological structure manipulator, used as effective tool combat through dynamic coupling. A corresponding method put forward reduce responses controllable freedom. By planning motion...
Obesity-induced elevated serum free fatty acids (FFAs) levels result in the occurrence of type 2 diabetes mellitus (T2DM). However, molecular mechanism remains largely enigmatic. This study was to explore effect and KLF15 on FFAs-induced abnormal glucose metabolism.Levels TG, TC, HDL-C, LDL-C, were measured by different assay kits. qRT-PCR Western Blot used detect GPR120, GPR40, phosphorylation p38 MAPK, KLF15, downstream factors.KLF15 decreased visceral adipose tissue obesity subjects...
<title>Abstract</title> Tumor cells evolve strong antioxidant capacities to counteract the abnormal high level of reactive oxygen species (ROS) in tumor microenvironment. Glutamate-cysteine ligase catalyzing subunit (GCLC) for synthesis glutathione (GSH) represents key enzyme maintain redox homeostasis cells, however, whether its activity is regulated by posttranslational modifications, such as succinylation, remains be clarified. Here, we demonstrate existence succinylation modification on...
ABSTRACT The de‐ubiquitinase USP33 has been shown to possess either tumour‐promoting or inhibitory effect on human cancer cells. However, all these findings are mainly based in vitro cell culture models, and the vivo evidence, which is more plausible digest functional role of carcinogenic process, still lacking. Here, we demonstrate that modulates DNA damage responses including cycle arrest apoptosis induction through associating with p53. It directly interacts p53 mediate its...
Objectives The feasibility of utilizing 4% sodium citrate as an alternative locking solution for central venous catheters (CVCs) (excluding dialysis catheters) was assessed. Methods Using heparin saline and solution, then 152 patients in ICU undergoing infusion with catheters, were randomly assigned to receive either 10 U/mL or citrate. used outcome indicators include: four indexes blood coagulation at minutes after 7 d the first locking, bleeding around puncture site subcutaneous hematoma...
Obesity-induced abnormal bone marrow microenvironment is an important risk factor for metastasis of prostate cancer (PCa). This study was intended to investigate whether obesity-induced elevated palmitic acid (PA), the most abundant free fatty acids (FFAs), increased CCL2 through GPRs/KLF7 pathway in adipocytes(BMA) promote growth and PCa. In BALB/c nude mice, we found that distribution BMA cavity high diet(HFD) mice were significantly higher than normal diet(ND) mice. More importantly,...
Abstract Background: Obesity-induced elevated serum free fatty acids (FFAs) levels result in the occurrence of type 2 diabetes mellitus (T2DM). However, molecular mechanism remains largely enigmatic. This study was to explore effect and KLF15 on FFAs-induced abnormal glucose metabolism. Methods: Levels TG, TC, HDL-C, LDL-C, were measured by different assay kits. qRT-PCR Western Blot used detect GPR120, GPR40, phosphorylation p38 MAPK, KLF15, downstream factors. Results: decreased visceral...