A5067281894- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Soil Carbon and Nitrogen Dynamics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Legume Nitrogen Fixing Symbiosis
- Hydrology and Watershed Management Studies
- Protist diversity and phylogeny
- Soil and Water Nutrient Dynamics
- Caveolin-1 and cellular processes
- Analytical Chemistry and Sensors
- Fusion materials and technologies
- Particle accelerators and beam dynamics
- Microbial Fuel Cells and Bioremediation
- Microbial Community Ecology and Physiology
- Theology and Canon Law Studies
- Advanced biosensing and bioanalysis techniques
- Rice Cultivation and Yield Improvement
- Magnetic confinement fusion research
- Monoclonal and Polyclonal Antibodies Research
- Neurological disorders and treatments
- Synthesis and bioactivity of alkaloids
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Chinese Academy of Sciences
2008-2024
University of Chinese Academy of Sciences
2024
Shanghai Center For Bioinformation Technology
2024
Beijing Institute of Genomics
2024
Hefei First People's Hospital
2024
Institute of Subtropical Agriculture
2010-2019
Kunming Institute of Botany
2015-2017
Hefei Institutes of Physical Science
2016
Apoptosis resistance is a hurdle for cancer treatment. HECTD3, new E3 ubiquitin ligase, interacts with caspase-8 death effector domains and ubiquitinates K63-linked polyubiquitin chains that do not target degradation but decrease the activation. HECTD3 depletion can sensitize cells to extrinsic apoptotic stimuli. In addition, inhibits TNF-related apoptosis-inducing ligand (TRAIL)-induced cleavage in an ligase activity-dependent manner. Mutation of ubiquitination site at K215 abolishes...
Wnt signaling pathway is aberrantly activated in a variety of cancers, especially colorectal cancer (CRC), because mutations the genes encoding adenomatous polyposis coli (APC), β-catenin and Axin. Small-molecule antagonists Wnt/β-catenin are attractive candidates for developing effective therapeutics CRC. In this study, we have identified novel inhibitor, isopropyl 9-ethyl-1- (naphthalen-1-yl)-9H-pyrido[3,4-b]indole-3- carboxylate (Z86). Z86 inhibited reporter activities expression...
Abstract Star-PAP is a noncanonical poly(A) polymerase and required for the expression of select set mRNAs. However, pathological role in cancer largely remains unknown. In this study, we observed decreased breast cell lines tissues. Ectopic inhibited proliferation as well colony-forming ability cells. patients, high levels correlated with an improved prognosis. Moreover, by regulating BIK (BCL2-interacting killer), induced apoptosis cells through mitochondrial pathway. The growth xenografts...
RNA binding protein RBM10 participates in various metabolism, and its decreased expression or loss of function by mutation has been identified many human cancers. However, how dysregulation contributes to cancer pathogenesis remains be determined. Here, we found that was breast tumors, patients with low presented poorer survival rates. depletion cells significantly promotes the cellular proliferation migration. We further demonstrated forms a triple complex YBX1 phosphatase 1B (PPM1B), which...
This paper presents a renewable biochemical oxygen demand (BOD) microsensor based on sensing element of magnetically functionalized microorganism and transducer ultramicroelectrode array (UMEA). Different from the traditional BOD sensor which includes an immobilized microbial film, was retained UMEA with permanent magnet to simplify modification process renew film. After respiration microorganism, used detect concentration change dissolved (DO). The showed linear range 2 20 mg/L, correlation...
Pump is a key sub-system which drives the heavy liquid metal circulation in experimental loops. In paper, hydraulic and mechanical performances of an electromagnetic pump (EMP) were tested test facility named PREKY-I. The results showed that EMP worked at good state when working current was up to 170 ampere. this condition, flow rate 5m3/h, pressure head 7.5bar, outlet temperature kept 380°C during test. performance close expected design parameters. had run continuously for 200 hours with...