Abstract It is increasingly clear that cancer a complex systemic disease and one of the most fatal diseases in humans. Complex systems, including cancer, exhibit critical transitions which system abruptly shifts from state to another. However, predicting these difficult as may show little change before tipping point reached. Models for are generally not accurate enough reliably predict where will occur. Additionally, there often gap between theoretical results clinical practice. To address...

Initiation and progression of cancer depend on many factors. Those the genetic level are often considered crucial. To gain insight into physical mechanisms breast cancer, we construct a gene regulatory network (GRN) which reflects both environmental aspects cancer. The construction GRN is based available experimental data. Three basins attraction, representing normal, premalignant states respectively, were found phenotypic landscape. can be seen as switching transitions between different...

Currently, the molecular mechanisms underlining male infertility are still poorly understood. Our previous study has demonstrated that PIWI-interacting RNAs (piRNAs) downregulated in seminal plasma of infertile patients and can serve as biomarkers for infertility. However, source mechanism dysregulation piRNAs remain obscure. In this study, we found exosomes present high concentrations human confirmed predominantly exosomal fraction plasma. Moreover, showed were significantly decreased...

Abstract Star-PAP is a noncanonical poly(A) polymerase and required for the expression of select set mRNAs. However, pathological role in cancer largely remains unknown. In this study, we observed decreased breast cell lines tissues. Ectopic inhibited proliferation as well colony-forming ability cells. patients, high levels correlated with an improved prognosis. Moreover, by regulating BIK (BCL2-interacting killer), induced apoptosis cells through mitochondrial pathway. The growth xenografts...

Recurrence and metastasis have been regarded as two of the greatest obstacles to cancer therapy. Cancer stem cells (CSCs) contribute development, with distinctive features recurrence resistance popular treatments such drugs chemotherapy. In addition, recent discoveries suggest that epithelial mesenchymal transition (EMT) is an essential process in normal embryogenesis tissue repair, well being a required step metastasis. Although there are many indications connections between cells, these...

Fire-resistant tree species play a crucial role in forest fire prevention, utilizing several physiological and molecular mechanisms to respond extreme heat stress. Many transcription factors (TFs) genes are known be involved the regulatory network of stress response plants. However, their roles high temperatures induced by remain less understood. In this study, we investigated Schima superba, fire-resistant tree, elucidate these mechanisms. Leaves S. superba seedlings were exposed...

Dysregulation of microRNA-370 (miR-370) is involved in a variety cancers, but its roles bladder cancer (BC) remain largely unexplored. Therefore, we designed this study to explore the role miR-370 BC.We took advantage biochemical assays, including RT-qPCR, Western blot, CCK-8, flow cytometry, transwell, xenograft tumor formation, and immunohistochemistry (IHC) for research.The expression was found be downregulated during development BC, highly correlating with malignant transformation...

Aim: Bladder cancer (BC) is one of the most common malignancies with poor prognosis. We aimed to identify a genetic signature for predicting prognosis BC. Materials & methods: Kaplan–Meier survival and Cox regression analyses were used construct prognostic using data from The Cancer Genome Atlas. Results: Fifty four upregulated 47 downregulated immune-related genes (IRGs) identified in A based on expression five IRGs was determined, which moderately accurate tumors. correlated tumor stage,...

Objective: Citron Rho-Interacting Serine/Threonine Kinase (CIT) was originally identified as a binding partner of active forms the small GTPases Rho and Rac.This kinase participated in regulation cytokinesis loss CIT associated with chromosomal instability.Here, we assume that might be potential prognostic biomarker for bladder cancer. Materials Methods:The expression significance mRNA were validated on 5 published microarray data sets, including 948 cancer cases.To further confirm results,...

Gastric cancer is a daunting disease with tragic impact on global health. It the fourth most common and has become second frequent cause of death in recent times. According to Lauren classification, gastric can be classified into two types: intestinal diffuse. Intestinal-type (IGC) more elderly people, atrophic gastritis (AG) metaplasia (IM) have been proven main premalignant causes intestinal-type cancer. In turn, Helicobacter pylori infection identified as significant AG IM. this study, we...

Gastric cancer is highly prevalent in Asia and characterized by poor prognosis post-surgery a high recurrence rate within five years. Research has highlighted the role of Helicobacter pylori initiating or accelerating gastric development. However, quantitative analysis its impact on carcinogenesis still lacking. This study employs gene regulatory networks landscape flux theory, integrating genetic epigenetic factors, to quantitatively elucidate how influences progression. Varied infection...

Recurrence and metastasis have been regarded as two of the greatest obstacles for curing cancer. Cancer stem cell (CSC) found. They contribute to cancer development with distinct feature recurrence resistance popular treatments such drugs chemotherapy. In addition, recent discoveries suggest that epithelial mesenchymal transition (EMT) is an essential process in normal embryogenesis tissue repair, which a required step metastasis. Although there are many indications showing connections...

Abstract Background: Cyclin D3-CDK6 complex is a component of the core cell cycle machinery that regulates proliferation. By using Human Protein Atlas database, higher expression level this was found in gastric cancer. However, function cancer remain poorly understood. This study aims to determine pattern and investigate its biological role during tumorigenesis.Methods: To demonstrate regulate c-Myc/miR-15a/16 axis feedback loop cancer, series methods were conducted both vitro vivo...

Spermatogenesis is a highly orchestrated dynamic developmental process, during which piRNAs play an indispensable role. Our previous studies have confirmed that the levels of piR-1207 and piR-2107 were significantly decreased in spermatozoa seminal plasma patients with asthenozoospermia, compared fertile controls. In order to explore function human spermatogenesis their potential regulatory downstream genes, we examined transcriptomic landscape mouse spermatocyte cell line GC-2spd(ts)...

Heterogeneity is ubiquitous in stem cells (SC), cancer (CS), and (CSC). SC CSC heterogeneity manifested as diverse sub-populations with self-renewing unique regeneration capacity. Moreover, the progeny possesses multiple plasticity cancerous characteristics. Many studies have demonstrated that one of greatest obstacle for therapy. This leads to incomplete anti-cancer therapies transitory efficacy. Furthermore, numerous micro-metastasis wide spread tumor across body which beginning...

Heterogeneity is ubiquitous in stem cells (SC), cancer (CS), and SC (CSC). This heterogeneity manifests the form of diverse sub-populations SC, CS, CSC with self-renewal unique regeneration capacity. Moreover, progeny possess multiple plasticity cancerous characteristics. Many studies have demonstrated that among greatest obstacles to successful anti-cancer therapy. leads incomplete therapy transitory efficacy. Furthermore, numerous micro-metastases lead spread tumor widely across body; this...