A5014504120- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Glioma Diagnosis and Treatment
- Osteomyelitis and Bone Disorders Research
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Cancer Diagnosis and Treatment
- Exercise and Physiological Responses
- Lipid metabolism and disorders
- Sensor Technology and Measurement Systems
- Fault Detection and Control Systems
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroblastoma Research and Treatments
Shihezi University
2021-2025
Second Hospital of Liaohe Oilfield
2011
Tianjin University
2006
Abstract Type 2 diabetes mellitus (T2DM) has rapidly increased worldwide, emerging as the fifth leading cause of death. The treatment T2DM is challenging due to side effects oral hypoglycemic drugs and limited efficacy long-term insulin therapy, which can lead resistance (IR). Consequently, there significant in discovering new that have minimal a pronounced effect. In obesity, microRNA levels been implicated glucose metabolism disorders T2DM, although many aspects remain unresolved. Here, we...
Abstract Background Obesity-induced abnormal bone marrow microenvironment is one of the important risk element for metastasis in prostate cancer (PCa). The present study aimed to determine whether obesity-induced elevation palmitic acid (PA), which most abundant free fatty acids (FFAs), increased CCL2 via GPRs/KLF7 pathway adipocytes (BMA) facilitate PCa growth and metastasis. Methods We constructed a bone-tumor bearing mouse model with obesity through high-fat diet, observed tumor formation...
The present study aimed to explore the molecular mechanism underlying regulation of glucose metabolism by miR-548ag. For first time, we found that miR-548ag expression was elevated in abdominal adipose tissue and serum subjects with obesity type 2 diabetes mellitus (T2DM). conditional knockout Dicer notably reduced content mouse tissue, serum, liver tissue. combined use RNAseq, an miRNA target gene prediction software, dual luciferase reporter assay confirmed exerts a targeted regulatory...
In previous study, we found that the content of medium-chain fatty acid Caprylic Acid (FFA C8:0) may be an important risk factor obesity induced prostate cancer (PCa). However, relationship between FFA C8:0 and PCa has not been reported. this explored whether can promotes progression by up-regulating Krüppel-like 7 (KLF7).We collected tissues from patients Benign Prostate Hyperplasia (BPH), constructed a primary-tumor bearing mouse model with through high-fat diet, observed tumor formation...
Abstract In the obesity context, inflammatory cytokines secreted by adipocytes lead to insulin resistance and are key metabolic syndrome development. our previous study, we found that transcription factor KLF7 promoted expression of p‐p65 IL‐6 in adipocytes. However, specific molecular mechanism remained unclear. present KLF7, PKCζ, p‐IκB, p‐p65, epididymal white adipose tissue (Epi WAT) mice fed a high‐fat diet (HFD) was significantly increased. contrast, decreased Epi WAT fat conditional...
Abstract Aim/Introduction Obesity is considered an important risk factor for many metabolic disorders, especially type 2 diabetes mellitus, and microRNAs (miRNAs) play a vital role in the development of mellitus. Therefore, we conducted this study to investigate miR‐4431 obesity‐associated pathobiology Materials methods Subjects were divided into normal control ( n = 36), obese mellitus 12) groups, serum levels analyzed. Adenovirus‐vectored mimic or sponge was intraperitoneally injected diet...
Stress-inducible interleukin 6 (IL-6) is generated in brown adipocytes via beta-3 adrenergic receptor (ADRB3) signaling, which necessary stress hyperglycemia, the kind of metabolic adaptation enabling "fight or flight" response by means liver gluconeogenesis. Nevertheless, mechanism ADRB3 signaling mediates IL-6 remains unclear. As a result, it critical to understand how produce signaling. We found that agonist and cold stimulation promoted expression KLF7 mice. In parallel these results...
Obesity is a high-risk factor in the development of endometrial cancer (EC). Our previous study observed that miR-548ag was significantly overexpressed sera obese individuals. Here, we report function and its mechanism promoting obesity-related progression EC. The content increased serum EC Bioinformatics analysis indicated survival rate patients with higher expression reduced. Mps One Binder Kinase Activator 1B (MOB1B, core member Hippo signaling pathway) direct target gene miR-548ag, which...
Obesity-induced abnormal bone marrow microenvironment is an important risk factor for metastasis of prostate cancer (PCa). This study was intended to investigate whether obesity-induced elevated palmitic acid (PA), the most abundant free fatty acids (FFAs), increased CCL2 through GPRs/KLF7 pathway in adipocytes(BMA) promote growth and PCa. In BALB/c nude mice, we found that distribution BMA cavity high diet(HFD) mice were significantly higher than normal diet(ND) mice. More importantly,...