Abstract Tumor cells evolve strong antioxidant capacities to counteract the abnormal high level of reactive oxygen species (ROS) in tumor microenvironment. Glutamate-cysteine ligase catalyzing subunit (GCLC) for synthesis glutathione (GSH) represents key enzyme maintain redox homeostasis cells, however, whether its activity is regulated by posttranslational modifications, such as succinylation, remains be clarified. Here, we demonstrate existence succinylation modification on GCLC vitro and...

DatalogMTL is a powerful rule-based language for temporal reasoning. Due to its high expressive power and flexible modeling capabilities, it suitable wide range of applications, including tasks from industrial financial sectors. However, due computational complexity, practical reasoning in highly challenging. To address this difficulty, we introduce new method which exploits the magic sets technique—a rewriting approach developed (non-temporal) Datalog simulate top-down evaluation with...

<title>Abstract</title> Gastric Carcinoma (GC) is the world’s third-highest cause of death by cancer. Cuproptosis a newly discovered programmed cell dependent on overload copper-induced mitochondrial respiration dysregulation. We speculated this regulatory (RCD) mechanism might serve as potential prognostic predictors and therapy for GC patients. The expression mutation patterns 12 cuproptosis-related genes were systematically evaluated in training group. Through unsupervised clustering...

In the double neutron star merger or star-black hole model for short GRBs, outflow launched might be mildly magnetized and rich. The neutron-rich will accelerated by magnetic thermal pressure may form a two component jet finally, as suggested Vlahakis, Peng &amp; Königl (2003). We show in this work that such could well reproduce multi-wavelength afterglow lightcurves, particular X-ray flat segment, of GRB 051221A. model, central engine need not to active much longer than prompt $γ-$ray emission.

Dust in the host galaxies of gamma-ray bursts (GRBs) dims and reddens their afterglow spectra. Knowledge nature this dust is crucial for correcting extinction, providing clues to GRB progenitors, probing interstellar medium high-redshift as well cosmic when universe was much younger were less evolved. The extinction properties are still poorly known. Unlike previous work, we derive Letter curves 10 without a priori assumption any specific types (such those Milky Way or Small/Large Magellanic...

We intend to determine the type of circumburst medium and measure directly initial Lorentz factor $\Gamma_0$ GRB outflows. If early X-ray afterglow lightcurve has a peak whole profile across is consistent with standard external shock model, rise light curves can be used differentiate whether burst was born in interstellar (ISM) or stellar wind. In thin shell case, related sub-relativistic reverse shock, time occurring after end prompt emission, derive an accurate $\Gamma_0$, especially for...

GRB 021211 was first detected by HETE II and its early afterglow has been observed. There is a break in light curve at about 12 min after the bursts, before optical flux decays with power-law index of -1.6, while late time slope -1 (Chornock et al. [CITE]). Here we will show that can be explained within framework standard fireball model. We emission contribution from both reverse shock forward shock, mainly due to emission. From fitting give constraints on parameters: initial Lorentz factor...

For gamma-ray bursts (GRBs) born in a stellar wind, as the reverse shock crosses ejecta, usually shocked regions are still precipitated by prompt MeV γ-ray emission. Because of tight overlapping photon flow with regions, optical depth for GeV photons produced shocks is very large. These high energy absorbed and generate relativistic e^\pm pairs. pairs re-scatter soft X-ray from forward well power detectable emission, significant part which sub-GeV range. Since total contained region...

With the successful launch of Swift Gamma-ray Burst Explorer, it is widely expected that prompt optical flashes like GRB 990123 would be easily detected. However, observations show for a number bursts (GRBs) no early flash has been detected, which indicates reverse shock emission must suppressed. Here we explore possibility may arise from internal emission. For and 060111b, although their are not correlated with gamma-ray emission, propose here different shocks (which can formed by collision...

view Abstract Citations (12) References (22) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Pulsed and Unpulsed Gamma-Ray Emission from Millisecond Pulsars Wei, D. M. ; Cheng, K. S. Lu, T. We use the outer gap model to study gamma-ray emission pair production processes of millisecond pulsars. The small light cylinder pulsars results in a large optical depth for gamma rays produced inside cylinder. Electron/position cascade will take place until energy...

<title>Abstract</title> Tumor cells evolve strong antioxidant capacities to counteract the abnormal high level of reactive oxygen species (ROS) in tumor microenvironment. Glutamate-cysteine ligase catalyzing subunit (GCLC) for synthesis glutathione (GSH) represents key enzyme maintain redox homeostasis cells, however, whether its activity is regulated by posttranslational modifications, such as succinylation, remains be clarified. Here, we demonstrate existence succinylation modification on...

Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide. Early detection risk stratification are crucial for effective management. This study evaluates the efficacy coronary computed tomography angiography (CTA) in CHD screening analyses its correlation with traditional factors an asymptomatic population. focused on 1,000 patients aged 40-80 years who visited two comprehensive tertiary hospitals region between January 2020 December 2022. Patients history...

DatalogMTL is a powerful rule-based language for temporal reasoning. Due to its high expressive power and flexible modeling capabilities, it suitable wide range of applications, including tasks from industrial financial sectors. However, due computational complexity, practical reasoning in highly challenging. To address this difficulty, we introduce new method which exploits the magic sets technique -- rewriting approach developed (non-temporal) Datalog simulate top-down evaluation with...

Abstract The aim of the study is to investigate preoperative prediction value computed tomography (CT) radiomics combined with traditional imaging features in grading clear cell renal carcinoma (CCRCC) by extracting and analyzing CT information patients CCRCC. One hundred thirty four CCRCC who were admitted our Hospital, Sun Yat‐sen University (Futian, Shenzhen), between June 2019 2023 enrolled this study. According WHO/ISUP classification standard, divided into high differentiation group...

The relation between the spin period ( P s ) and orbital o in high-mass X-ray binaries (HMXBs) is investigated. In order for Be/X-ray to locate above critical line of observable emission due accretion, it necessary an intermediate eccentricity be introduced. We suggest that some peculiar systems − diagram are caused by their magnetic fields.

The Burst and Transient Source Experiment (BATSE) has shown that the sky distribution of gamma-ray bursts (GRBs) is remarkably isotropic but non-uniform, which implies observed may occur either in an extended galactic halo or at cosmological distances. For Galactic origin, Hartmann & Narayan have argued rotational energy neutron stars insufficient by orders magnitude to provide burst rate. Here we calculated period dead pulsars found indeed be account for total bursts, because only a small...

In Swift era, X‐ray flares have been observed in a good fraction of gamma‐ray bursts (GRBs), the rapid variability timescale (small values δt/t) and very steep decay index α (α>3)imply that these should be originated from internal shocks (the so called "late shock"). The early optical flashes may correlated or uncorrelated with emission. For former case, emission lower energy extension emission, synchrotron‐self‐Compton (SSC) component While for latter arise reverse external shock produced...