A5003926989- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Animal Disease Management and Epidemiology
- Cutaneous lymphoproliferative disorders research
- Ferroptosis and cancer prognosis
- Genetics and Neurodevelopmental Disorders
- Medicinal Plant Pharmacodynamics Research
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Immune cells in cancer
- Click Chemistry and Applications
- Medical Device Sterilization and Disinfection
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Synthesis and Biological Evaluation
- Phytochemistry and Biological Activities
- Gout, Hyperuricemia, Uric Acid
- Immune Response and Inflammation
- RNA regulation and disease
Xinxiang Medical University
2015-2025
Xinxiang University
2023
First Affiliated Hospital of Xinxiang Medical University
2010-2021
Jining First People's Hospital
2021
Xi'an Jiaotong University
2010
Herpes simplex virus type I (HSV-1) infection is associated with lung injury; however, no specific treatment currently available. In this study, we found a significant negative correlation between FcRn levels and the severity of HSV-1-induced injury. HSV-1 increases methylation promoter, which suppresses expression by upregulating DNMT3b expression. Analysis promoter revealed that -1296- to -919-bp region key regulatory region, CG site at -967/-966 bp being critical site. The transcription...
IL-25 is an important immune regulator that can promote Th2 response-dependent immunity, inflammation, and tissue repair in asthma, intestinal infection, autoimmune diseases. In this study, we examined the effects of renal ischemic/reperfusion injury (IRI). Treating IRI mice with significantly improved function reduced injury. Furthermore, treatment increased levels IL-4, IL-5, IL-13 serum kidney promoted induction alternatively activated (M2) macrophages kidney. Notably, also frequency type...
Viral myocarditis (VM) is an inflammatory disease posing a serious threat to public health, with various viral pathogens contributing its pathogenesis. Coxsackievirus B3 (CVB3) the most frequently implicated causative agent and has been extensively studied because of high prevalence severity. No specific therapeutic interventions for VM exist, vaccine development encountered substantial challenges. Therefore, we aimed develop novel CVB3 mucosal as preventive strategy against VM....
Melanoma is one of the most fatal and therapy-resistant types cancer; therefore, identifying novel therapeutic candidates to improve patient survival an ongoing effort. Previous studies have revealed that pimozide not sufficient treat melanoma; enhancing treatment necessary. Indoleamine 2, 3‑dioxygenase (IDO) immunosuppressive, intracellular rate-limiting enzyme, which contributes immune tolerance in various tumours, including melanoma, inhibition IDO may be considered a strategy when...
Efficacy of clinical chemotherapeutic agents depends not only on direct cytostatic and cytotoxic effects but also involves in eliciting (re)activation tumour immune effects. One way to provoke long-lasting antitumour immunity is coined as immunogenic cell death (ICD), exploiting the host system against cells a "second hit". Although metal-based complexes hold promise potential agents, ruthenium (Ru)-based ICD inducers remain sparse. Herein, we report half-sandwich complex Ru(II) bearing...
Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt‑domain family factors, has been reported to be susceptibility gene for psoriasis. The present study was designed delineate role underlying mechanism RUNX3 involved in differentiation helper (Th) 17 Th22 cells results demonstrated that expression increased significantly CD4‑positive (CD4+) from patients with psoriasis, compared healthy controls. In...
Psoriasis is a chronic skin disease characterized by hyperproliferation of keratinocytes and increased inflammation. Previous studies have detected the levels cytokines in serum patients with psoriasis, yet few multi-cytokine combination been reported.The aim study was to compare between psoriasis healthy controls, elucidate which factors influence progression.A total 39 30 volunteers were enrolled. The venous blood collected 13 inflammatory measured human inflammation panel 1 kit. severity...
Synthetic CpG oligodeoxynucleotides (ODNs), as TLR9 agonists, have been found to play a possible role in antitumor effect. In order determine the effect of YW002, known C-type ODN, on treatment hepatocellular carcinoma (HCC), which is one most aggressive carcinomas, we chose inject YW002 at doses 12.5 g and 25 per mouse 7 days post-tumor challenge. The survival rate mice was recorded every day. On day 14 postinjection, five each group were bled randomly sacrificed. level IFN- or TNF- serum...
To investigate the effects of fragile histidine triad (FHIT) restoration on cell proliferation and apoptosis in human cutaneous T-cell lymphoma line, Hut-78, vitro nude mouse. Wild-type FHIT gene was transfected by liposome into Hut-78 cells. The alteration growth curve soft agar colony formation studied mice. stably expressed cells after transfection. Compared with controls, expression inhibited induced apoptosis. Tumor vivo strongly suppressed restoration. Our data demonstrate inhibit...
Human T‑cell leukemia virus type 1 (HTLV‑1), the first retrovirus to be identified, is etiological agent of an aggressive clonal malignancy mature CD4+ T lymphocytes known as adult (ATL). The prognosis ATL patients remains poor despite availability a number clinical chemotherapy drugs. In addition, HTLV‑1‑infected and cells possess intrinsic resistance anticancer 2'‑Deoxy‑2'‑β‑fluoro‑4'‑azidocytidine (FNC) novel pyrimidine analog that efficiently phosphorylated by cellular kinases substrate...
Background: Psoriasis vulgaris (PsV) is an immune-mediated skin disease of unknown mechanism. Interleukin 33 (IL-33) a member IL-1 cytokine family and suppression tumorigenicity 2 (ST2) the specific ligand IL-33. It has been found that IL-33 ST2 are increased in psoriatic lesions, but expression levels serum their relationship to clinical features still unclear. The aim this study assess IL-33, ST2, IL-17 IL-5 as well concentration blood glucose lipids PsV patients with characteristics....
Background and Aims: Concanavalin A (ConA) administration induces a rapid severe liver injury in mice, invariant natural killer T (iNKT) cells are recognized to be the key effector this process. However, underlying regulatory mechanisms not well defined. Approach Results: We found that iNKT constitutively expressed TIPE2 (Tumor necrosis factor-α-induced protein 8-like 2, or TNFAIPL2). Genetic ablation strongly sensitized mice ConA-induced hepatitis, accompanied with hyperactivation of cells....
Obesity is a health problem of great concern to the whole society. Numerous studies have shown that obesity can lead changes in types and numbers immune cell subsets molecules visceral adipose tissues, IL-33/ST2 plays crucial role maintaining homeostasis. This paper reviewed regulatory effects on adipocytes cells as well IL-33 tissues body during recent years. Key words: IL-33; ST2; Fat; Obesity; Immune
Objective To investigate the influences of recombinant human high mobility group protein 1 (rhHMGB1) on expression HMGB1-related receptors in Human T-cell leukemia virus type (HTLV-1) infected MT2 T cells.Methods rhHMGB1 was added to HTLV-l-positive cells at a final concentration μg/ml.Equal volume PBS used set up control.After 24 h culture,the and distribution surface molecules including advanced glycosylation end products (RAGE),T cell immunoglobulin mucin 3 (TIM-3) toll like receptor 4...