A5008691346- Parkinson's Disease Mechanisms and Treatments
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Neurological disorders and treatments
- Erythropoietin and Anemia Treatment
- EEG and Brain-Computer Interfaces
- High-Voltage Power Transmission Systems
- Cardiovascular Disease and Adiposity
- Pain Management and Placebo Effect
- Kruppel-like factors research
- Neurology and Historical Studies
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Ideological and Political Education
Shanghai Institute of Nutrition and Health
2021-2023
Shanghai Jiao Tong University
2018-2023
University of Chinese Academy of Sciences
2022-2023
University of Electronic Science and Technology of China
2019-2022
Abstract The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment T3, the active form TH, increases thermogenic capacity in interscapular BAT male mice through hyperplasia by promoting TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals heterogeneous nature and hierarchical trajectory within cells BAT. Further analyses suggest T3 facilitates state...
Thyroid hormone (TH) has a profound effect on energy metabolism and systemic homeostasis. Adipose tissues are crucial for maintaining whole-body homeostasis; however, whether TH regulates metabolic homeostasis through its action adipose is unclear. Here, we demonstrate that administration of triiodothyronine (T3), the active form TH, affects both inguinal white tissue (iWAT) metabolism. Taking advantage mouse model lacking adipocyte receptor (TR) α or TRβ, show TRβ major TR isoform mediates...
The mechanisms underlying the pathogenesis of steatosis and insulin resistance in nonalcoholic fatty liver disease remain elusive. Increased phosphorylation hepatic p38 has long been noticed liver; however, whether activation is a cause or consequence unclear. Here, we demonstrate that by MKK6 overexpression mice induces severe steatosis, reduces fat mass, elevates circulating acid levels p38α- FGF21-dependent manner. Mechanistically, through increasing FGF21 production from liver, increases...
Iodine is an essential micronutrient for producing thyroid hormone (TH); however, iodide excess can lead to adverse thyroidal effects. Unfortunately, the lack of a proper in vitro model system hampered studies effect on physiology and pathology. Here, we demonstrated that excessive intake downregulated genes related TH synthesis thyroids mice. Since sodium has no these cultured cell lines, developed three-dimensional (3D) culture enable murine thyrocytes form organoids with follicle-like...
We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task compared potential efficacy recombinant-human erythropoietin (rHuEPO) performance Parkinson’s Disease patients. The samples 18 medicated PD patients (nine them received rHuEPO addition their usual anti-PD medication through random allocation other nine regular only) 9 age education-matched healthy controls (HCs) who completed with...
Abstract We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task compared potential efficacy recombinant-human erythropoietin (rHuEPO) performance Parkinson’ s Disease patients. The samples 18 medicated PD patients (nine them received rHuEPO addition their usual anti-PD medication through random allocation other nine regular only) 9 age education-matched healthy controls (HCs) who completed...
Ideological and political level of college students is closely associated with education development in each period.Ideological colleges should also be valued.According to current situations, proper management ideology politics represents such defects laggard cognition, imperfect system unmatched system.Ideological accomplishment improve.This requires improvement.So, this paper proposes improvement approaches ideological provides useful reference for future work.
In order to know the audible noise characters of transmission line and its influence on nearby residents'lives, measurement extraction method based singular value decomposition technology was presented. The results show that sound pressure level obtained by Fourier transform is larger than decomposition; spectrum field are different between day night, which mainly due interference background such as beetle frog calls in course night testing; extracted by. acoustic spectral characteristics...
Abstract Background Cognitive impairment is a feature of Parkinson’s Disease (PD) from the early stages, but currently, no treatment for cognitive deficits in PD available. Erythropoietin (EPO) has been studied its potential neuroprotective properties neurologic disorders with beneficial action on cognition. Objective To evaluate if NeuroEPO, new formulation EPO low content sialic acid, improves function patients. Methods A double-blind, randomized, placebo-controlled physician lead trial...