A5100412263- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Gastric Cancer Management and Outcomes
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- Supercapacitor Materials and Fabrication
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Endometriosis Research and Treatment
- Cancer survivorship and care
- Crystal structures of chemical compounds
- Colorectal Cancer Screening and Detection
- Endometrial and Cervical Cancer Treatments
- Lanthanide and Transition Metal Complexes
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Synthesis and biological activity
- Cervical Cancer and HPV Research
- Family Support in Illness
Huazhong University of Science and Technology
1985-2025
Southern Medical University
2021-2025
The First People's Hospital of Shunde
2025
General Hospital of Shenyang Military Region
2025
Guizhou Provincial People's Hospital
2024
Zhejiang Chinese Medical University
2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Anhui Medical University
2023
Guangxi Medical University
2023
<h3>Importance</h3> Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with stroke is lacking. <h3>Objective</h3> To assess the efficacy RIC for acute moderate stroke. <h3>Design, Setting, Participants</h3> This multicenter, open-label, blinded–end point, randomized trial including 1893 was conducted at 55...
High-fat diet, which leads to an increased level of deoxycholic acid (DCA) in the intestine, is a major environmental factor development colorectal cancer (CRC). However, evidence relating bile acids and intestinal tumorigenesis remains unclear. In this study, we investigated effects DCA on mucosal barrier its impact CRC. Here showed that disrupted cell monolayer integrity proinflammatory cytokine production precancerous lines (Caco-2 IMCE). Apcmin/+ mice receiving number size adenomas...
Abstract The gut microbiota and the bile acid pool play pivotal roles in maintaining intestinal homeostasis. Bile acids are produced liver from cholesterol metabolized intestine by microbiota. Gut dysbiosis has been reported to be associated with colorectal cancer. However, interplay between metabolism during carcinogenesis remains unclear. In present study, we investigated potential of cholic (CA; a primary acid)‐induced adenoma‐adenocarcinoma sequence. Apc min/+ mice, which spontaneously...
Abstract Background This study aimed to establish nomogram models of overall survival (OS) and cancer-specific (CSS) in elderly colorectal cancer (ECRC) patients (Age ≥ 70). Methods The clinical variables confirmed as ECRC between 2004 2016 were retrieved from the Surveillance, Epidemiology, End Results (SEER) database. Univariate multivariate analysis performed, followed by construction nomograms OS CSS. A total 44,761 cases finally included this study. Both C-index calibration plots...
Objective: The study aims to explore the relationship between expressions of HER2 and JAK/STAT3-SOCS3 signaling pathway clinicopathological features prognosis ovarian cancer (OC).Methods: A total 136 OC patients were collected. Immunohistochemistry was applied measure STAT3, p-STAT3, SOCS3, p-HER2 in tumor tissues adjacent normal tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) used detect mRNA HER2, SOCS3 STAT3 western blotting for protein p-HER2, p-STAT3 Flow cytometry...
Previous studies have shown that fruits different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three aimed at studying the of Syzygium samarangense, Passiflora edulis Solanum muricatum injury in mice. animals were treated daily with fruit juices for fifteen days. Chronic treatment increased levels aspartate transaminase (AST), alanine (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), decreased protein (TP). Histopathological...
Constructing bimetallic sulfides with ideal structures could effectively alleviate the poor cycling stability of rechargeable Mg batteries due to a synergistic effect. An exquisite yolk-shell structured sulfide NiCo2S4 synthesized via two-step solvothermal hydrothermal method is investigated as cathode material for batteries. With strategy and well-designed architecture, as-synthesized exhibits outstanding Mg-storage performance, demonstrating superior reversible capacity (270 mA h g-1 at 50...
Reprogrammed metabolism is an important basis of colorectal cancer (CRC) progression; however, its mechanisms remain unclear. This study illustrated a novel mechanism for long noncoding RNA (lncRNA) CRCMSL in CRC, which was identified as CRC suppressor our previous study. To investigate whether suppresses by interfering lipid metabolism. Potential functions were predicted GSEA, led to lipidomics. Ferroptosis process evaluated protein markers, probe-reported peroxidation signals and...
Electrolyte engineering to enhance the cathode-electrolyte interface stability is widely recognized as a promising strategy for achieving high-voltage lithium-ion batteries, which are currently hindered by meta-stable surface of lithium-rich layered oxides. Despite significant progress in electrolyte development, clear design guidelines electrolytes remain lacking, making solvent selection unpredictable. Here, dual-descriptor tailoring concept based on Mulliken charge (adsorption) and...
The development of cost-effective and straightforward methodologies for the fabrication high-performance electrode materials represents a crucial advancement in application evolution supercapacitors (SCs). Hierarchical porous carbon materials...
Abstract Elevating the upper cutoff voltage to 4.6 V could effectively increase reversible capacity of LiCoO 2 (LCO) cathode, whereas irreversible structural transition, unstable electrode/electrolyte interface and potentially induced safety hazards severely hinder its industrial application. Building a robust cathode/electrolyte film by electrolyte engineering is one efficient approaches boost performance high-voltage LCO (HV-LCO); however, elusive interfacial chemistry poses substantial...
138 papillary thyroid carcinoma (PTC) samples were assessed for somatic mutation profile and fusion genes by targeted resequencing using a cancer panel (ThyGenCapTM) targeting 244 cancer-related 20 potential genes. At least one genetic alteration (including mutations genes) was observed in 118/138 (85.5%) samples. The most frequently mutated gene BRAF V600E (57.2%). Moreover, we identified 11 including eight previously reported ones three novel genes, UEVLD-RET, OSBPL9-BRAF, SQSTM1-NTRK3....
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) aberrantly overexpressed clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to chemoresistance human and mice.We obtained tissue samples from measured expression by immunohistochemistry. Gain- loss-of-function assays were performed study biological functions PTK6. constructed FLAG-tagged wild type (WT), kinase-dead,...
Background: Colon cancer is one of the leading malignant neoplasms worldwide. Until now, concrete mechanisms colonic cancerogenesis are largely unknown; identification driven genes and pathways is, therefore, great importance for monitoring conquering this disease. This study aims to explore potential biomarkers therapeutic targets colon treatment. Methods: The gene expression profile GSE44076 from Gene Expression Omnibus database, including 98 primary cancers normal distant mucosa, was...
Histological subtype plays an important role in the different clinical characteristics and survival outcomes of patients with colorectal carcinoma (CRC). However, previous studies, influences tumor locations stages have not been strictly controlled. This study focused on assessment prognostic value each histological CRC. We used Surveillance, Epidemiology, End Results (SEER) database (1973-2011) to analyze 818,229 CRC pathological features, analyzed subtype. Under condition stratification by...
To reduce the dependence on traditional fossil energy, developing efficient energy storage systems is urgent. The reserves of aluminum resources in earth's crust are extremely rich, which makes aluminum-ion batteries a promising competitor new devices. Here, we report poly(3-methylthiophene)/graphene (P3TH/Graphene) composite as cathode an battery. adjustment polymer chain spacing by methyl side provides channel conducive to transport large-size AlCl4- complexes. addition electron donor...
Abstract High fat diet is implicated in the elevated deoxycholic acid ( DCA ) intestine and correlated with increased colon cancer risk. However, potential mechanisms of intestinal carcinogenesis by remain unclarified. Here, we investigated carcinogenic effects using tumour cells Apc min/+ mice model. We found that could activate epidermal growth factor receptor EGFR promote release ligand amphiregulin AREG ), but not HB ‐ EGF or TGF ‐α cells. Moreover, ADAM ‐17 was required ‐induced...
The present study was to develop a prognostic nomogram predict overall survival (OS) and cancer-specific (CSS) in early-onset colon cancer (COCA, age < 50). Patients diagnosed as COCA between 2004 2015 were retrieved from the surveillance, epidemiology, end results (SEER) database. All included patients assigned into training validation sets. Univariate multivariate analysis used identify independent variables for construction of nomogram. discrimination calibration plots measure accuracy A...