A5114664722- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Aquatic Ecosystems and Phytoplankton Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Lower Extremity Biomechanics and Pathologies
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Folate and B Vitamins Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Photodynamic Therapy Research Studies
- Vitamin D Research Studies
- Diabetes and associated disorders
- Menopause: Health Impacts and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and biosynthesis
- Lipid metabolism and disorders
Zhengzhou University
2021-2025
Zhengzhou Business University
2025
Southwest University
2023-2024
Second Military Medical University
2019-2024
Eastern Hepatobiliary Surgery Hospital
2019-2024
Nanjing Medical University
2024
Capital Medical University
2022
Qiqihar Medical University
2022
Taiyuan University of Technology
2018
Soochow University
2017
Two recent genome-wide association studies have identified several novel type 2 diabetes susceptibility variants in intron 15 of the KCNQ1 gene. We aimed to evaluate effects on and metabolic traits population mainland China. Three candidate single nucleotide polymorphisms were genotyped 1,912 individuals with 2,041 normal controls using ligase detection reaction method. confirmed Allele frequency ORs three (SNPs) were: rs2237892 (OR 1.19, 95% CI 1.08–1.31, p = 3.0 × 10−4); rs2237895 1.20,...
Fatigue can significantly alter an athlete’s biomechanics and performance, which increase their risk of injury. Important basketball moves like jump shots (JS) countermovement jumps (CMJ) primarily use the muscles in lower back limbs. Basketball players’ jumping mechanics, injury during CMJ, JS, ankle sprains were all examined. A total 415 male collegiate players participated league, this season representing varying levels mechanics. Surface electromyography, a force plate, 3D motion...
A number of recent genome-wide association (GWA) studies have identified several novel genetic determinants plasma lipid and lipoprotein concentrations in European populations. However, it is still unclear whether these loci Caucasian GWA also exert the same effect on a Chinese population. We genotyped 10 single-nucleotide polymorphisms (SNPs) nine Han population sample (n = 4,192) assessed associations SNPs with metabolic traits, using linear regression adjusted for age, gender, diabetes...
Late-onset Alzheimer Disease (LOAD) is a common neurodegenerative disease, and one of its major pathologic characteristics senile plaques. Proteins encoded by SORL1 ACE have been shown to be related the processing, trafficking, degradation Amyloid-β, principal component In this paper, we investigated whether are associated with LOAD. We recruited 144 LOAD patients 476 controls from Shanghai, China conducted case-control study on 9 single-nucleotide polymorphisms (SNPs): 6 in (rs2070045,...
Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in central nervous system (CNS), and services many biological functions such as neural survival, differentiation, plasticity. Previous studies have suggested that Val66Met (also known rs6265 or G196A) variant of BDNF associated with bipolar disorder (BPD), but results been inconclusive. We therefore genotyped polymorphism a Han Chinese population sample (498 cases 501 control subjects). found genotype BPD...
Previous studies have demonstrated that both Wnt5a and Sonic hedgehog (Shh) are involved in regulating the pathfinding of descending serotonergic (5-HT, 5-hydroxytryptamine) axons an opposite manner brainstem. Shh Wnt signaling pathways interact to guide post-crossing commissural axons, where acts as a repellent directly shaping gradient indirectly by expression frizzled-related protein 1 (Sfrp1). Whether such mechanism functions 5-HT axon guidance remains unknown. Here, we found core...
As a key regulator of insulin secretion and metabolism glucose, cholesterol fatty acid, hepatocyte nuclear factor 4 α (HNF4A) was suggested as candidate gene for type 2 diabetes (T2D); however, no association study between HNF4A T2D in the Chinese population has been conducted before. To address this issue, we evaluated impact variants (rs1884614 rs2425637) on metabolic traits 1912 unrelated patients 2041 control subjects Han population. Our results that individual single nucleotide...
In wetland ecosystems, small shallow lakes are critical transition zones of land and water, which usually dominated by aquatic plants with different growth forms. However, the differences key influencing factors phytoplankton communities in unclear. On this basis, nine surveys were conducted at five sampling sites three Zhangye National Wetland Park from June to November 2022, respectively emergent
Patients with biliary tract cancer (BTC) often have dismal outcomes due to the poor performance of traditional methods for early diagnosis. Recently, bile cell-free DNA (cfDNA) has been reported as a potential liquid biopsy material BTC However, is complex alkaline aqueous medium, and proper storage conditions remain be explored. The aim this study explore effects storing under various on stability cfDNA determine optimal conditions, thereby establishing foundation subsequent application in...