A5056568626- Oral microbiology and periodontitis research
- Gut microbiota and health
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Oral and Maxillofacial Pathology
- dental development and anomalies
- Infant Nutrition and Health
- TGF-β signaling in diseases
- Single-cell and spatial transcriptomics
- Dental Health and Care Utilization
- Legionella and Acanthamoeba research
- Hedgehog Signaling Pathway Studies
- Endodontics and Root Canal Treatments
- Gastrointestinal motility and disorders
- Oral Health Pathology and Treatment
- Drilling and Well Engineering
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
Peking University
2018-2024
National Clinical Research Center for Digestive Diseases
2023-2024
Inflammatory bowel disease (IBD) involves chronic inflammation, loss of epithelial integrity, and gastrointestinal microbiota dysbiosis. Effective therapies for IBD have not been established. Accordingly, in this study, we evaluated the effects inorganic nitrate, a potent nitric oxide (NO) donor regulator, mouse model dextran sodium sulfate (DSS)-induced colitis. Mice were pretreated with NaNO3 (2 mM) their drinking water 5 days, NaCl was used as control. Feces collected analyses. The...
Inflammatory bowel disease (IBD) is a common immune-related of the gastrointestinal tract that affects many people around world. Extraintestinal manifestations IBD have been frequently observed in recent years; one these, periodontitis, has gained increasing attention. Periodontitis chronic inflammatory characterized by inflammation and destruction periodontal tissues due to disruption host immune homeostasis. Clinical studies revealed associated with IBD. However, detailed heterogeneity...
Introduction: Porphyromonas gingivalis and Enterococcus faecalis promote the development of pulpitis periapical periodontitis. These bacteria are difficult to eliminate from root canal systems, leading persistent infection poor treatment outcomes. We explored response human dental pulp stem cells (hDPSCs) bacterial invasion mechanisms underlying impact residual on regeneration. Methods: Single-cell sequencing was used categorize hDPSCs into clusters based their P. E. . depicted a single-cell...
The midpalatal suture is mainly responsible for the growth and development of maxillary resistance to rapid expansion (RME). It essential clinical researchers explore intramembrane ossification elucidate underlying mechanism maturation process help identify optimum time force RME. However, mechanistic studies associated with are rare. aim this present study create an osteogenesis model region mice. Interestingly, we discovered a type chondrogenic mesenchymal cell expressing Piezo2, which...
Microbial pathogens invade various human organs, including the oral cavity.
Objectives Initial oral microbial colonization has complicatedly interacted with growth and development. The aim of our study was to discover links between microbiota community structure mode delivery, maternal factors, such as systemic diseases, abortion history, pregnancy complications. Methods A total 177 pregnant women their neonates were enrolled at Peking university people’s hospital. We collected samples, medical development phenotype used a 16S rRNA gene sequence analyze diversity...