In this study, we identified hsa_circ_0051240 was significantly increased in ovarian cancer (OC) tissues. Our results indicated that silencing of inhibited OC cell proliferation, migration and invasion vitro, also prevented tumour formation vivo. addition, the inhibitory effects by blockage could be attenuated miR-637 inhibitor. Furthermore, act as a sponge miR-637, directly targeted KLK4 mRNA cells. Altogether, promotes through inhibiting miR-637/KLK4 axis. Therefore, these demonstrated...

Background. Currently available tests are insufficient to distinguish patients with epithelial ovarian cancer (EOC) from normal individuals. Metabolomics, a study of metabolic processes in biologic systems, has emerged as key technology the measurements small molecular metabolites tissues or biofluids. Material and methods. To investigate application metabolomics on selecting EOC-associated biomarkers, 173 plasma specimens (80 newly diagnosed EOC 93 individuals) were analyzed using...

Tumour necrosis factor-α-induced protein 8 (TNFAIP8) has been recently documented in various malignancies, but its role epithelial ovarian cancer (EOC) remains unknown. expression was determined by real-time reverse transcription PCR and western blot analysis. tissues, consisting of serous, mucinous, endometrioid clear cell histotypes, from 202 EOC patients (International Federation Gynecologists Obstetricians I–IV) who underwent primary cytoreduction were collected. Then, we examined the...

Curaxin CBL0137 was designed to regulate p53 and nuclear factor-κB simultaneously exhibits antitumor activity by inhibiting tumor cell proliferation inducing apoptosis in multiple cancers. However, whether can induce pyroptosis has not yet been reported. This study demonstrated that induces caspase-3/gasdermin E (GSDME)-dependent via the reactive oxygen species (ROS)/BAX pathway. In ovarian cancer cells, inactivated chromatin remodeling complex which could facilitate transcription, leading...

Abstract Receptor for activated C kinase 1 (RACK1) has been confirmed to take part in multiple biological events and the mechanism supporting abnormal RACK1 expression ovarian cancer (OC) remains be characterized. Here, we identified Smad ubiquitin regulatory factor 2 (SMURF2) as a bona fide E3 ligase of OC. SMURF2 effectively added K6, K33 K48 chains RACK1, resulting polyubiquitination instability RACK1. PCAF promoted acetylation at K130, leading SMURF2-mediated ubiquitination inhibited...

Abstract Background Ovarian cancer poses a serious threat to women's health. Due the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is novel tumor suppressor, but its role in occurrence and development still unclear. Methods investigated expression level pan-cancer through bioinformatics analysis, especially gynecological tumors. Function assays were used detect effect on malignant phenotype ovarian...

Metabolites are the end products of cellular regulatory processes. Squamous cervical cancer (SCC) can alter level certain small molecular metabolite in plasma through modulating gene expression. In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which significantly down- upregulated SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). external prospective cohort, our...

The early detection of ovarian carcinoma is difficult due to the absence recognizable physical symptoms and a lack sensitive screening methods.The currently available biomarkers (such as CA125 HE4) are insufficiently reliable distinguish stage (I/II) epithelial cancer (EOC) patients from normal individuals because they possess relatively poor sensitivity specificity.To evaluate application metabolomics biomarker discovery in stages (EOC), plasma samples 21 EOC 31 healthy controls were...

Ovarian cancer (OC) is a gynecological malignancy with poor prognosis and low survival rate. E2F2 transcription activator that plays an indispensable role in cell proliferation cycle progression. The preliminary analysis indicated the gene could produce three circular RNAs (circRNAs). This study aimed to investigate whether these circRNAs would be involved OC tumorigenesis. results showed one of (termed circE2F2) was significantly upregulated tissues lines, high circE2F2 expression...

Ubiquitin-specific protease 22 (USP22) exhibits an important function in tumor progression and oncogenesis. The aim of this study was to investigate the role USP22 association with its potential targets patients cervical cancer. To our knowledge, is first that determines relationship between expression clinicopathological significance immunohistochemistry results showed protein overexpressed cancer samples compared normal tissues (P < 0.001). Moreover, analysis highly related International...

Tumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how secreted by ovarian carcinoma cells regulate phenotype and function macrophages. Hypoxic treatment A2780 was postulated mimic tumor microenvironment, were co-cultured with TAMs. miR-1225-5p enriched in hypoxic contributed M2 macrophage polarizationby modulating Toll-like receptor 2 expression (TLR2). Furthermore, hypoxia-treated promote cancer cell...

Growing evidence indicates that F-box and leucine-rich repeat protein 6 (FBXL6) is associated with the progression of various cancers, including gastric cancer, hepatocellular carcinoma, colorectal cancer. This study focuses on prognostic significance FBXL6 in OC.

Lysosome-associated protein transmembrane 4β-35 (LAPTM4B-35) is a member of the mammalian 4-tetratransmembrane spanning superfamily, which overexpressed in several solid malignancies. However, expression LAPTM4B-35 and its role progression cervical carcinoma unknown. The aim this study was to determine level carcinoma. Immunohistochemistry used 53 intraepithelial neoplasias (CINs) 113 carcinomas comparison with 20 normal specimens. correlation between clinicopathologic characteristics...

Ovarian cancer (OvCa) is a malignant disease of the female reproductive system with high mortality rate. LncRNA has been confirmed to play crucial role in development and progression various types. Novel lncRNA ZFHX4-AS1 reported several cancers, albeit its functional mechanisms OvCa remain unclear.With reference public databases based on integrating bioinformatics analyses, we explored expression roles prognosis OvCa. We employed Kaplan-Meier curves investigate outcome patients different...

Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating biological processes PCOS. Our study was designed to explore function circ-FURIN PCOS.Circ-FURIN expression detected using RT-qPCR. The protein AVEN, BCL2, XIAP and AREL1 measured western blot. Dual-luciferase reporter RNA pull-down assays were applied clarify interaction between miR-195-5p or BCL2. Functionally, cell proliferation...

The function of Vasohibin-1 (VASH1) in human cancer has not been thoroughly or comprehensively examined. Here, we identified the tumor suppressor part VASH1 across cancers, including epithelial ovarian tumors. Our study carefully contrasted expression pancancer and nontumorous tissues a public database to explore its regulatory role clinical prognosis, diagnosis, purity, immune cell infiltration. Next, explored antitumor mechanism through drug sensitivity, functional enrichment, phenotypic...

A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between polymorphism and susceptibility to endometrial carcinoma (EC). an adjusted multivariate logistic regression analyses, subjects with LAPTM4B*1/2 *2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041–2.375) 2.335-fold CI 1.365–3.995) increases risk of developing EC...

Objective: To investigate the relationship between F box/WD-40 domain protein 7 (FBXW7) and cervical squamous cancer.Methods: We investigated FBXW7 expression in 136 carcinoma cases through immunohistochemistry Western-blot analysis to evaluate clinical significance of elucidate with progression-free survival (PFS) overall (OS).Results: Low was associated high histologic grade, lymphovascular space invasion lymph node metastasis, among other parameters. Patients low exhibited poor OS...

SLC15A family members are known as electrogenic transporters that take up peptides into cells through the proton-motive force. Accumulating evidence indicates aberrant expression of may play crucial roles in tumorigenesis and tumor progression various cancers, they participate metabolism. However, exact prognostic role each member human lung cancer has not yet been elucidated.We investigated accumulated data from TCGA other available online databases by integrated bioinformatics analysis to...

Ovarian cancer is one of the most common cancers and can be treated with microtubule-targeting drugs. Checkpoint forkhead ring finger domains (CHFR) a protein implicated in sensitivity to Whereas CHFR downregulation, often promoter hypermethylation, has been identified large number tumor types, it not ovarian cancer. We therefore searched for downregulation primary tumors.Fresh tissues from 53 patients (test) normal 21 (control) were tested hypermethylation mRNA levels.The was...

Cervical cancer (CC) is the leading cause of cancer-related death in women. A limited number studies have investigated whether immune-prognostic features can be used to predict prognosis CC. This study aimed develop an improved prognostic risk scoring model (PRSM) for CC based on immune-related genes (IRGs) survival and determine key IRGs.We downloaded gene expression profiles clinical data patients from TCGA GEO databases. The ESTIMATE algorithm was calculate score both immune stromal...