A5101855775- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Vibrio bacteria research studies
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Bioenergy crop production and management
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Sphingolipid Metabolism and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Advanced Sensor and Energy Harvesting Materials
- Advanced Materials and Mechanics
- Plant Pathogenic Bacteria Studies
- Cytokine Signaling Pathways and Interactions
- Renal cell carcinoma treatment
- Adenosine and Purinergic Signaling
- Mycobacterium research and diagnosis
- PI3K/AKT/mTOR signaling in cancer
- Endometrial and Cervical Cancer Treatments
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
University of Hong Kong
2024
Sun Yat-sen University
2020-2023
Harbin Medical University
2005-2022
Third Affiliated Hospital of Harbin Medical University
2011-2022
Shanghai East Hospital
2022
Zhongshan Hospital of Xiamen University
2018
Baoding University
2017
Abstract The last decades have witnessed the rapid growth of hydrogel bioelectronics. Traditional hydrogels face challenges when working under extreme conditions, causing a loss stabilities and functionalities. This review provides systematic overview capable with focus on their applications in bioelectronic systems. These are summarized into categories anti‐mechanical damage, anti‐detachment, anti‐swelling, anti‐freezing, anti‐foreign body response. Strategies including material development...
Cyclic diguanosine monophosphate (c-di-GMP) is widely used by bacteria to control biological functions in response diverse signals or cues. A previous study showed that potential c-di-GMP metabolic enzymes play a role the regulation of biofilm formation and motility Acinetobacter baumannii . However, it was unclear whether how A. cells use signaling modulate functions. Here, we report an important intracellular signal modulation formation, motility, virulence The level principally controlled...
Abstract Quorum sensing (QS) signals are widely utilized by bacteria to regulate biological functions in response cell population density. Previous studies have demonstrated that Ralstonia solanacearum employs two different types of QS systems. We report here anthranilic acid controls important and the production R. solanacearum. It was biosynthesis is mainly performed TrpEG. The accumulation transcription trpEG occur a density-dependent manner Both TrpEG homologues conserved various...
Many bacteria utilize quorum sensing (QS) to control group behavior in a cell density-dependent manner. Previous studies have demonstrated that Acinetobacter baumannii employs an N-acyl-L-homoserine lactone (AHL)-based QS system biological functions and virulence. Here, we report indole controls functions, virulence AHL signal production A. baumannii. The biosynthesis of is performed by A1S_3160 (AbiS, synthase), which novel synthase annotated as alpha/beta hydrolase Heterologous expression...
Colorectal cancer (CRC) is a prevalent malignant tumour that causes considerable cancer-related deaths globally. The sphingolipid transporter 2 (SPNS2), sphingosine-1-phosphate (S1P) transporter, modulates multiple biological events including malignancy of cells. In this study, the effects SPNS2 on CRC progression were studied. We found expression was significantly upregulated in tissues compared to adjacent non-tumour tissues. To assess role cells, we performed loss- and gain-of-function...
Purpose . To investigate the association between CpG island methylator phenotype (CIMP) and overall survival of sporadic colorectal cancer (CRC) in Northeast China. Methods 282 CRC patients were recruited this study. We selected MLH1 , MGMT p16 APC MINT1 MINT31 RUNX3 as CIMP panel markers. The promoter methylation was assessed by sensitive high resolution melting (MS-HRM). Proportional hazards-regression models fitted with computing hazard ratios (HR) corresponding 95% confidence intervals...
Abstract Background Noninvasive diagnostic markers that are capable of distinguishing patients with colorectal cancer (CRC) from healthy individuals or other types lacking. We report the discovery and validation a panel methylation-based specifically detect CRC. Methods This was large-scale study based on publicly available datasets coupled where multiple specimens six cohorts CRC, types, were used to identify validate tissue-specific methylation patterns CRC assess their performance....
Previous studies have demonstrated that bis-(3',5')-cyclic diguanosine monophosphate (bis-3',5'-c-di-GMP) is a ubiquitous second messenger employed by bacteria. Here, we report 2',3'-cyclic guanosine (2',3'-cGMP) controls the important biological functions, quorum sensing (QS) signaling systems and virulence in Ralstonia solanacearum through transcriptional regulator RSp0980. This signal specifically binds to RSp0980 with high affinity thus abolishes interaction between promoters of target...
Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in EC cells tissues when compared their controls. Targeted inhibition ERRα by siRNA its inverse agonist XCT-790 can suppress migration invasion Both si-ERRα decreased expression transforming growth factor-beta (TGF-β). directly bind with promoter...
The emerging evidence has demonstrated the critical roles of long non-coding RNAs (lncRNAs) as regulators in tumor immune microenvironment (TIME). However, infiltration-associated lncRNAs and their clinical significance colon cancer have not yet been thoroughly investigated. This study performed an integrative analysis lncRNA expression profiles cell infiltration identified 258 lncRNAs. Of them, four (AC008494.3, LINC00926, AC022034.1, SNHG26) were significantly independently associated with...
Colorectal cancer (CRC) remains one of the most common malignancies worldwide and its mechanism is unclear. Polymeric immunoglobulin receptor (PIGR) which plays an important role in mucosal immunity widely expressed epithelium dysregulated different tumors. However, underlying mechanisms PIGR CRC remain Here, we demonstrated that was hypermethylated downregulated our cohort (N = 272), these features were associated with reduced overall survival patients (HRmethylation 1.61, 95% CI...
A selective and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed validated for the determination of ziyuglycoside I (I), 3β,19α-dihydroxyurs-12-en-28-oic-acid 28-β-d-glucopyranosyl ester (II), 3β-[(α-l-arabinopyranosyl) oxy]-urs-12,18(19)-dien-28-oic acid β-d-glucopyranosyl (III), rosamultin (IV), 1β-hydroxyeuscaphic (V) alpinoside (VI) in rats after oral administration Sanguisorba officinalis L. (S. officinalis) extract. The...
Abstract Background Colorectal cancer (CRC) represents a common malignancy in gastrointestinal tract. Iodine-125 ( 125 I) seed implantation is an emerging treatment technology for unresectable tumors. This study investigated the mechanism of I function CRC cells. Methods The cells were irradiated with different doses (0.4, 0.6 and 0.8 mCi). miR-615 expression tissues adjacent was detected by RT-qPCR. intervened mimic or inhibitor, then treated 5-AZA (methylation inhibitor). cell growth,...
Mulberry (Morus alba L.), a moderately salt-tolerant tree species, is considered to be economically important. In this study, 1-year-old mulberry seedlings cultivated in soil under greenhouse conditions were treated with five concentrations of sodium chloride (NaCl; 0%, 0.1%, 0.2%, 0.3%, and 0.5%) for 3 21 days. Plant growth parameters not affected by 0.1% NaCl, but significant reductions observed after treatment 0.5% NaCl. The malondialdehyde content cell membrane stability exposed NaCl did...
Abstract Polycomb repressive complex 2 (PRC2) is a multicomponent with methyltransferase activity that catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). Interaction the epigenetic reader protein EED EZH2, catalytic unit PRC, allosterically stimulates PRC2 activity. In this study, we investigated role and underlying mechanism in acute kidney injury (AKI) by using EED226, highly selective inhibitor, to target EED. Administration EED226 improved renal function, attenuated...
Expression and function of histone deacetylases (HDACs) vary with cell types pathological conditions. Our recent studies showed that pharmacological targeting class IIa HDACs attenuated renal fibrosis, but the effect HDAC inhibition on acute kidney injury (AKI) remains unknown. In this study, we found four (4, 5, 7, 9) were highly expressed in folic acid (FA) ischemia/reperfusion (I/R)-induced AKI mice. Administration TMP269, a potent selective inhibitor, improved reduced tubular apoptosis,...
Burkholderia cenocepacia is an important human opportunistic pathogen that can cause life-threatening infections in susceptible individuals. It employs quorum-sensing (QS) systems to regulate biological functions and virulence.
Indole is an important signal employed by many bacteria to modulate intraspecies signaling and interspecies or interkingdom communication. Our recent study revealed that indole plays a key role in regulating the physiology virulence of Acinetobacter baumannii. However, it not clear how A. baumannii perceives responds modulating biological functions. Here, we report controls through previously uncharacterized response regulator designated as AbiR (A1S_1394), which contains cheY-homologous...
Cervical cancer (CC) is the leading cause of cancer-related death in women. A limited number studies have investigated whether immune-prognostic features can be used to predict prognosis CC. This study aimed develop an improved prognostic risk scoring model (PRSM) for CC based on immune-related genes (IRGs) survival and determine key IRGs.We downloaded gene expression profiles clinical data patients from TCGA GEO databases. The ESTIMATE algorithm was calculate score both immune stromal...
Outer membrane vesicle (OMV)-delivered Pseudomonas quinolone signal (PQS) plays a critical role in cell-cell communication aeruginosa. However, the functions and mechanisms of membrane-enclosed PQS interspecies microbial communities are not clear. Here, we demonstrate that delivered by both OMVs from P. aeruginosa liposome reduces competitiveness Burkholderia cenocepacia, which usually shares same niche lungs cystic fibrosis patients, interfering with quorum sensing (QS) B. cenocepacia...