A5001170329- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Disaster Management and Resilience
- Historical Art and Architecture Studies
- Plant Pathogens and Fungal Diseases
- Comparative Literary Analysis and Criticism
- Bacterial Identification and Susceptibility Testing
- Historical Studies of Medieval Iberia
- Nosocomial Infections in ICU
- Latin American Urban Studies
- Mycotoxins in Agriculture and Food
- Antibiotic Use and Resistance
- Urbanism, Landscape, and Tourism Studies
- Architecture and Art History Studies
- Human Rights and Immigration
- Galician and Iberian cultural studies
- Influenza Virus Research Studies
- Infectious Diseases and Mycology
- Environmental and Cultural Studies in Latin America and Beyond
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Immune Response and Inflammation
- Administrative Law and Governance
- Medicinal Plants and Neuroprotection
- Latin American Literature Analysis
University of Chile
2005-2024
Hospital Universitario de Valme
2008-2023
Florida International University
2023
National University of San Marcos
2023
Instituto de Biomedicina de Sevilla
2021
Universidad de Sevilla
2009-2021
Complejo Hospitalario de Cáceres
2020
Universidad Nacional de Cuyo
2018
Institute of Geography of the Slovak Academy of Sciences
2005
Objective: To assess the usefulness of "Candida score" (CS) for discriminating between Candida species colonization and invasive candidiasis (IC) in non-neutropenic critically ill patients. A rate IC <5% patients with CS <3 was primary end point. Design: Prospective, cohort, observational study. Setting: Thirty-six medical-surgical intensive care units Spain, Argentina, France. Patients: total 1,107 adult unit admitted at least 7 days April 2006 June 2007. Measurements Main Results: Clinical...
Pandemic A/H1N1/2009 influenza causes severe lower respiratory complications in rare cases. The association between host immune responses and clinical outcome cases is unknown.We utilized gene expression, cytokine profiles generation of antibody following hospitalization 19 critically ill patients with primary pandemic pneumonia for identifying associated outcome. Ingenuity pathway analysis 8.5 (IPA) (Ingenuity Systems, Redwood City, CA) was used to select, annotate visualize genes by...
To assess the performance of Candida albicans germ tube antibody (CAGTA), (1 → 3)-ß-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC). A prospective study 233 non-neutropenic SAC on admission expected stay ≥ 7 days. CAGTA (cutoff positivity 1/160), BDG (≥80, 100 200 pg/mL), mannan-Ag (≥60 mannan-Ab (≥10 UA/mL) were measured twice a week, only treated systemic...
We aimed to assess the percentage of azole resistance in Aspergillus fumigatus Spain.Thirty participating Spanish hospitals stored all morphologically identified A. sensu lato clinical isolates-regardless their significance-from 15 February 14 May 2019. Isolates showing according EUCAST 9.3.2 methodology were molecularly and cyp51A gene was studied stricto isolates.Eight hundred forty-seven isolates from 725 patients collected 29 (A. (n = 828) cryptic species 19)). mostly lower respiratory...
Antifungal resistance is increasing by the emergence of intrinsically resistant species and development secondary in susceptible species. A previous study performed Spain revealed levels azole molds between 10 12.7%, but Aspergillus fumigatus was not detected. We used itraconazole (ITZ)-supplemented medium to select strains. total 500 plates supplemented with 2 mg/liter ITZ were sent Spanish tertiary hospitals, molecular identification antifungal susceptibility testing performed. In...
We aimed to analyze whether the lack of inclusion specific recommendations for management candidemia is an independent risk factor early and overall mortality. Multicenter study adult patients with in 13 hospitals. assessed proportion on whom nine ESCMID IDSA guidelines had been applied, analyzed its impact 455 episodes were documented. Patients who died within first 48 hours excluded. Sixty-two percent received appropriate antifungal treatment. Either echinocandin or amphotericin B therapy...
Serum phosphate is a key parameter in the management of chronic kidney disease-mineral and bone disorder (CKD-MBD). The timing measurement not standardized current guidelines. Since optimal range these biomarkers may vary depending on duration interdialytic interval, this analysis Current secondary hyperparathyroidism: multicentre observational study (COSMOS), we assessed influence 2- (midweek) or 3-day (post-weekend) dialysis interval for blood withdrawal serum levels CKD-MBD their...
ABSTRACT The susceptibilities of 63 isolates Aspergillus spp. to voriconazole were evaluated by a modified NCCLS M38-A method and the Sensititre YeastOne method. overall agreement was 82.5%, ranging from 100% for niger terreus 62.5% flavus . Discrepancies between methods due higher MICs. could have potential value susceptibility testing voriconazole.
Abstract Background Severe disease caused by 2009 pandemic influenza A/H1N1virus is characterized the presence of hypercytokinemia. The origin exacerbated cytokine response unclear. As observed previously, uncontrolled virus replication could strongly influence production. objective present study was to evaluate relationship between host responses and viral levels in critically ill patients. Methods Twenty three patients admitted ICU with primary pneumonia were included this study. A...
Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented presence mixed yeast (MY) infections. Here, we describe epidemiology, clinical, microbiological characteristics MY infections causing invasive in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected each center between April to September 2018, they sent reference confirm identification by sequencing methods perform antifungal...
The definite and rapid diagnosis of invasive aspergillosis is necessary because the high mortality caused. objective this study was to evaluate a real-time PCR assay detect Aspergillus spp. in clinical samples, based on Light Cycler technology. Specificity assessed by using DNA extracted from pathogenic non-pathogenic bacteria/fungi Spanish Collection including: two flavus, four fumigatus, nidulans, niger terreus isolates. analytical sensitivity evaluated with different inocula (10(1)-10(5)...
We analyzed the species distribution and susceptibility patterns of 433 strains Aspergillus spp. isolated from respiratory samples 419 in-patients included in multicenter prospective study (FUNGAE-IFI) between July 2014 October 2015. Identification was carried out by conventional methods at each participating center molecular sequencing a portion β-tubulin gene one centers. In vitro evaluated broth microdilution using E-test (for cryptic species). Species identified 249 A. fumigatus sensu...
Abstract The goal of this study was to validate an optimized sample preparation method for filamentous fungal isolates coupled with the use in-house library identification moulds using Matrix Assisted Laser Desorption/Ionization-Time Flight Mass Spectrometry (MALDI-TOF MS) in a multicenter context. For that purpose, three Spanish microbiology laboratories participated 97 MALDI-TOF MS Filamentous Fungi 3.0 (Bruker Daltonics) and containing 314 unique references. analyzed belonged 25 species...
Uno de los impactos medioambientales más negativos que ha tenido el crecimiento explosivo la Región Metropolitana Santiago en las últimas décadas, sido contaminación cursos agua por vertimiento aguas servidas.En actualidad, servidas a nivel nacional son sometidas tratamientos, lo implica un aporte al mejoramiento calidad recursos hídricos general.Un subproducto este tratamiento es generación biosólidos, alcanzan actualmente cifra 75.555 ton día -1 Región.Si bien estos lodos tienen...
This work aims to create a risk disaster management index measure how government institutions are dealing with disasters beyond legal and normative regulations advancing toward enforcement implementation. With the complexity of concept its scope in mind, analytic hierarchy process (AHP) methodology was used comprehensive capable measuring at national subnational levels. The checked for six Latin-American countries: Mexico, Nicaragua, Honduras, Colombia, Argentina, Chile, obtaining...
Besides advances in haemodialysis (HD), mortality rates are still high. The effect of the different types HD membranes on survival is a controversial issue. aim this COSMOS (Current management Of Secondary hyperparathyroidism: Multicentre Observational Study) analysis was to survey, patients, relationship between use conventional low- or high-flux and all-cause cardiovascular mortality.COSMOS multicentre, open-cohort, 3-year prospective study, designed evaluate mineral bone disorders...