A5017187640- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- GDF15 and Related Biomarkers
- MicroRNA in disease regulation
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Plant Pathogens and Fungal Diseases
- Hemoglobinopathies and Related Disorders
- Fungal Infections and Studies
- Abdominal Surgery and Complications
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
Institut universitaire du cancer de Toulouse Oncopole
2017-2024
Centre Hospitalier Universitaire de Toulouse
2011-2023
Institut Claudius Regaud
2019-2021
Hôpital Purpan
2010-2013
Inserm
2011
Centre de Recherche en Cancérologie de Toulouse
2011
Université de Toulouse
2011
Centre Hospitalier Universitaire d'Angers
1975
Abstract Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell metabolic homeostasis largely unknown cancer. Here, multiomics analyses uncovered a coordinated activation of C/EBPα Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism vivo patients with FLT3-mutant acute myeloid leukemia (AML). Mechanistically, regulated the fatty acid synthase (FASN)–stearoyl-CoA desaturase (SCD) axis to...
Hemophagocytic lymphohistiocytosis is a condition of immune dysregulation characterized by severe organ damage induced hyperinflammatory response and uncontrolled T-cell macrophage activation. Secondary hemophagocytic typically occurs in association with infections or malignancies. Patients acute myeloid leukemia may be prone to develop because an impaired high susceptibility infections. In series 343 patients treated intensive chemotherapy over 5-year period our center, we identified 32...
Patients with acute myeloid leukemia and a high white blood cell count are at increased risk of early death relapse. Because mediators inflammation contribute to leukostasis chemoresistance, dexamethasone added chemotherapy could improve outcomes. This retrospective study evaluated the impact adding or not in cohort 160 patients least 50×109 cells. In silico studies, primary samples, leukemic lines, xenograft mouse models were used explore antileukemic activity dexamethasone. There was no...
Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine-resistant cells from both AML lines and patient samples vivo vitro. cell-surface expression activity increased upon chemotherapy compared diagnosis, enrichment CD39-expressing blasts a marker adverse prognosis clinics. High promotes cytarabine resistance enhancing...
Abstract Classifications of acute myeloid leukemia (AML) patients rely on morphologic, cytogenetic, and molecular features. Here we have established a novel flow cytometry-based immunophenotypic stratification showing that AML blasts are blocked at specific stages differentiation where features normal myelopoiesis preserved. Six differentiation-arrest categories based CD34, CD117, CD13, CD33, MPO, HLA-DR expression were identified in two independent cohorts 2087 1209 patients. Hematopoietic...
Objective The aim of our study was to assess the incidence and identify predictive risk factors acute kidney injury after cytoreductive surgery cisplatin-based hyperthermic intra-peritoneal chemotherapy. Methods This is a retrospective from two centers evaluating patients with advanced or recurrent ovarian cancer who underwent followed by chemotherapy January 2007 December 2013. Patients were classified into groups according occurrence injury, defined as glomerular filtration rate at...
Acute myeloid leukemias (AML) are clonal diseases that develop from leukemic stem cells (LSC) carry an independent prognostic impact on the initial response to induction chemotherapy, demonstrating clinical relevance of LSC abundance in AML. In 2018, European LeukemiaNet published recommendations for detection measurable residual disease (Bulk MRD) and suggested exploration MRD use multiparametric displays.We evaluated performance unsupervised clustering post-induction assessment bulk 155...
Objectives: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill with neutropenic are scarce. Our objectives were to describe the population admitted an ICU and investigate risk factors invasive fungal disease. Design: A multicentric retrospective cohort study between January 2010 August 2017. Setting: Six French ICUs members Groupe de Recherche Respiratoire en Onco-Hématologie research network....
Chloé Medranoa, Lucie Obericb, Florent Puissetc, Christian Recherb, Delphine Larrieu-Cirond, Loïc Ysebaertb, Caroline Protinb, Muriel Picarde, Sophie Perriatc, Etienne Chatelutc , Sarah Bertolib, Françoise Huguetb, Suzanne Tavitianb & Stanislas Faguerafg*a Département de Néphrologie et Transplantation d'organes – Unité Réanimation, Centre Hospitalier Universitaire Toulouse, French Intensive Care Renal Network, Franceb Service d'Hématologie, Institut du Cancer Toulouse Oncopôle, Université...
Actinic reticuloid was observed in a patient following the development of porphyria cutanea tarda. A cutaneous lymphoma‐like infiltrate found histologically and at ultra‐structural level. In infiltrate, main population histiocytic, with some mast cells mononuclear cells. Most histiocytic contained numerous typical Langerhans granules worm‐like structures. Crystalloid cytoplasmic inclusions were occasionally detected.
Little is known about patients with sickle cell disease (SCD) who require intensive care unit (ICU) admission. The goals of this study were to assess outcomes in admitted the ICU for acute complications SCD and identify factors associated adverse outcomes. This multicenter retrospective included consecutive adults one 17 participating ICUs. An outcome was defined as death or a need life-sustaining therapies (non-invasive invasive ventilation, vasoactive drugs, renal replacement therapy,...
Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections. Few data available regarding neutropenic patients with NSTIs. Our objectives were to describe the characteristics and management of NSTIs in intensive care units (ICUs). We conducted a retrospective multicentre cohort study 18 ICUs between 2011 2021. Patients admitted concomitant neutropenia at diagnosis included compared non-neutropenic The relationship therapeutic interventions outcomes was assessed...
L-asparaginase is a key chemotherapeutic agent in acute lymphoblastic leukemia (ALL). It also known for multiple and severe specific toxicities, without consensual management. We report the case of 51-year-old man treated with recently diagnosed T-cell ALL. During treatment, he developed coma due to multifactorial diffuse cerebral edema, by hepatic encephalopathy, venous thrombosis, hyperammonemia, all linked toxicity L-asparaginase. Specific innovative treatments were employed manage these...
Abstract Usually responsible for soft tissue infections, Clostridioides species can also cause bacteremia, life-threatening infections often requiring intensive care unit (ICU) admission. We conducted a multicenter retrospective study to investigate bacteremia in ICUs describe the clinical and biologic characteristics outcomes critically ill patients. identified 135 patients with which occurred almost exclusively (96%) underlying conditions. Septic shock digestive symptoms were hallmarks of...
Sinusoidal obstruction syndrome (SOS) is a life-threatening liver complication of high- dose chemotherapy. Defibrotide the only available therapeutic option approved for SOS. The prognosis SOS in patients requiring intensive care unit (ICU) admission remains unknown. primary objective this study was to assess outcome ICU. This retrospective conducted between 2007 and 2019 13 French ICUs. Seventy-one critically ill adult with defined according European Society Blood Marrow Transplantation...