Marie-Laure Nicolau
A5027730244- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Moringa oleifera research and applications
- Malaria Research and Control
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Diverse Scientific Research Studies
- Retinoids in leukemia and cellular processes
- Computational Drug Discovery Methods
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Lysosomal Storage Disorders Research
- Autophagy in Disease and Therapy
- Pomegranate: compositions and health benefits
Centre Hospitalier Universitaire de Toulouse
2008-2023
Université Toulouse III - Paul Sabatier
2008-2023
Université de Toulouse
2008-2023
Laboratoire de Chimie de Coordination
2008-2010
Centre National de la Recherche Scientifique
2008-2010
Pierre Fabre (France)
2009
Inserm
2009
Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance metastasis in hematologic malignancies suggests that it could also play role drug resistance and acute myeloid leukemia (AML). In cohort 1,273 AML patients, we uncovered multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination leukemic blasts, increased risk after intensive chemotherapy, reduced event-free...
Malaria is one of the most significant causes infectious disease in world. The search for new antimalarial chemotherapies has become increasingly urgent due to parasites' resistance current drugs. Ellagic acid a polyphenol found various plant products. In this study, properties ellagic were explored. results obtained have shown high activity vitro against all Plasmodium falciparum strains whatever their levels chloroquine and mefloquine (50% inhibitory concentrations ranging from 105 330...
Abstract Classifications of acute myeloid leukemia (AML) patients rely on morphologic, cytogenetic, and molecular features. Here we have established a novel flow cytometry-based immunophenotypic stratification showing that AML blasts are blocked at specific stages differentiation where features normal myelopoiesis preserved. Six differentiation-arrest categories based CD34, CD117, CD13, CD33, MPO, HLA-DR expression were identified in two independent cohorts 2087 1209 patients. Hematopoietic...
Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance aryl-amino-alcohols and reduced susceptibility artemisinins. We demonstrate here that duplicated genotypes circulate West Africa. The monitoring this prevalence Africa appears essential for determining the antimalarial policy maintain efficiency artemisinin-based combination therapy (ACT) as long possible.
Acute myeloid leukemias (AML) are clonal diseases that develop from leukemic stem cells (LSC) carry an independent prognostic impact on the initial response to induction chemotherapy, demonstrating clinical relevance of LSC abundance in AML. In 2018, European LeukemiaNet published recommendations for detection measurable residual disease (Bulk MRD) and suggested exploration MRD use multiparametric displays.We evaluated performance unsupervised clustering post-induction assessment bulk 155...
Apoptosis is a highly organized, energy-dependent program by which multicellular organisms eliminate damaged, superfluous, and potentially harmful cells. Although caspases are the most prominent group of proteases involved in apoptotic process, role lysosomes has only recently been unmasked. This study investigated lysosomal serine protease CLN2 apoptosis. We report that cells isolated from patients affected with late infantile neuronal ceroid lipofuscinosis (LINCL) having deficient activity...
<div>Abstract<p>Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance metastasis in hematologic malignancies suggests that it could also play role drug resistance and acute myeloid leukemia (AML). In cohort 1,273 AML patients, we uncovered multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination leukemic blasts, increased risk after intensive...
<div>Abstract<p>Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance metastasis in hematological malignancies suggests that it could also play role drug resistance and acute myeloid leukemia (AML). In cohort 1,273 AML patients, we uncovered multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination leukemic blasts, increased risk after intensive...
<p>Single cell analysis</p>
<p>Multivariate analysis of the TUH cohort</p>
<p>Figure S2</p>
<p>Figure S3</p>
<p>Figure S1</p>
<p>CD36 gene signature</p>
<p>Human antibodies for flow cytometry analyses (TUH cohort)</p>
<p>Supplemental Text</p>
<p>Single cell analysis</p>
<p>CD36 gene signature</p>
<p>Multivariate analysis of the TUH cohort</p>
<p>Human antibodies for flow cytometry analyses (TUH cohort)</p>
<p>Supplemental Text</p>
<p>Figure S1</p>
<p>Figure S3</p>
<p>Figure S2</p>