A5015451821- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Lysosomal Storage Disorders Research
- Cell death mechanisms and regulation
- Pain Mechanisms and Treatments
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Flavonoids in Medical Research
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Cholinesterase and Neurodegenerative Diseases
- Immune cells in cancer
- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- ATP Synthase and ATPases Research
- Drug Transport and Resistance Mechanisms
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Microtubule and mitosis dynamics
- Autophagy in Disease and Therapy
- Plant-based Medicinal Research
- Cellular transport and secretion
- Axon Guidance and Neuronal Signaling
- Botulinum Toxin and Related Neurological Disorders
Inserm
2009-2023
Université Toulouse III - Paul Sabatier
2009-2023
Université de Toulouse
2013-2014
Centre de Recherche en Cancérologie de Toulouse
2012-2014
KU Leuven
2009
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation S1P catalyzed by lyase (SPL). The human SGPL1 gene that encodes SPL maps to region often mutated cancers. To investigate the effect deficiency on survival transformation, susceptibility anticancer drugs fibroblasts generated from SPL-deficient mouse embryos (Sgpl1(-/-)) was compared with...
Glycosphingolipids, which are abundant at the surface of melanoma cells, play crucial roles in tumor progression. We investigated whether a newly described glycosphingolipid hydrolase, encoded by GBA2 gene, can modulate human cell growth and death. expression was quantified on cells RT-qPCR. The antiproliferative effects were assessed expressing inducible established xenografts. As control an catalytically inactive mutant generated. Sphingolipid levels monitored mass spectrometry; unfolded...
Cell therapy based on endothelial colony-forming cells (ECFCs) is a promising option for ischaemic cardiovascular diseases. A better understanding of the mechanisms by which these promote revascularization remains critical challenge to improving their therapeutic potential. We aimed identify involved in activity ECFCs using paracrine properties mesenchymal stem (MSC).Conditioned medium from human bone marrow-derived MSCs (MSC-CM) increased angiogenic cord blood vitro (proliferation,...
Apoptosis is a highly organized, energy-dependent program by which multicellular organisms eliminate damaged, superfluous, and potentially harmful cells. Although caspases are the most prominent group of proteases involved in apoptotic process, role lysosomes has only recently been unmasked. This study investigated lysosomal serine protease CLN2 apoptosis. We report that cells isolated from patients affected with late infantile neuronal ceroid lipofuscinosis (LINCL) having deficient activity...
Human papillomavirus (HPV) is the second most common infectious agent causing cancer. Persistent infection with high-risk (HR)-HPV can lead to cervical intra-epithelial neoplasia and carcinomas (CC). While host immune response necessary for viral clearance, chronic activation contributes a low-grade inflammation that ultimately carcinogenesis. The micro-immunotherapy medicine (MIM) 2LPAPI® could be valuable tool manage clearance of virus reduce risk developing CC. In this in vitro study, we...
<div>Abstract<p>Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation S1P catalyzed by lyase (SPL). The human <i>SGPL1 </i>gene that encodes SPL maps to region often mutated cancers. To investigate the effect deficiency on survival transformation, susceptibility anticancer drugs fibroblasts generated from...
Supplementary Materials, Figures 1-5 from Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation
Supplementary Materials, Figures 1-5 from Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation
Besides neuronal cells, botulinum neurotoxins (BoNTs) can also affect other cell types such as fibroblasts or keratinocytes. These cells play a key role in skin conditions. Maintaining high-quality sebum secretion is essential to avoid premature aging. This study explored the effect of abobotulinumtoxinA (aboBoNT-A) rhino mouse. Briefly, anaesthetized animals were injected via intra-dermal route (ID; four sites injection) by either vehicle 0.1, 0.3 and 1 Unit aboBoNT-A per A reference group...
<div>Abstract<p>Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation S1P catalyzed by lyase (SPL). The human <i>SGPL1 </i>gene that encodes SPL maps to region often mutated cancers. To investigate the effect deficiency on survival transformation, susceptibility anticancer drugs fibroblasts generated from...