A5109211592- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Ultrasound in Clinical Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Trauma Management and Diagnosis
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Medical Imaging and Pathology Studies
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Diagnosis and treatment of tuberculosis
- Lung Cancer Treatments and Mutations
- Foreign Body Medical Cases
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 diagnosis using AI
Lancashire Teaching Hospitals NHS Foundation Trust
2015-2024
Royal Preston Hospital
2005-2024
University of Central Lancashire
2022-2024
University of Manchester
2024
Oxford University Clinical Research Unit Indonesia
2021
University of Dundee
2021
Medical Research Council
2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
### Monitoring, precautions and complications ### Hypoxaemia ### Cardiac arrhythmias ### Bleeding complications
The current management of advanced non-small cell lung cancer (NSCLC) requires differentiation between squamous and nonsquamous subtypes as well epidermal growth factor receptor (EGFR) mutation status. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is increasingly used for the diagnosis staging cancer. However, it unclear whether cytology specimens obtained with EBUS-TBNA are suitable subclassification genotyping NSCLC.To determine from in routine practice...
Malignant pleural effusion affects more than 750,000 persons each year across Europe and the United States. Pleurodesis with administration of talc in hospitalized patients is most common treatment, but indwelling catheters placed for drainage offer an ambulatory alternative. We examined whether administered through catheter was effective at inducing pleurodesis use alone.Over a period 4 years, we recruited malignant 18 centers Kingdom. After insertion catheter, underwent regularly on...
<h3>Background</h3> The assessment of medical trainees is becoming an increasingly prominent issue, with current methods having varying degrees inherent subjectivity and bias. Cusum analysis a technique used in quality control systems, starting to be employed training. Endobronchial ultrasound (EBUS) established tool the diagnosis staging lung cancer, although its use UK currently restricted. As it becomes more widespread, there will need assess trainees9 competence accurately ensure that...
This multicentre, blinded, sham-controlled study was performed to assess the safety and effectiveness of bronchial valve therapy using a bilateral upper lobe treatment approach without goal lobar atelectasis. Patients with predominant severe emphysema were randomised bronchoscopy (n=37) or (n=36) IBV Valves for 3-month blinded phase. A positive responder defined as having both ≥4-point improvement in St George's Respiratory Questionnaire (SGRQ) volume shift measured by quantitative computed...
Malignant pleural effusion (MPE) is challenging to manage. Talc pleurodesis a common and effective treatment. There are no reliable data, however, regarding the optimal method for talc delivery, leading differences in practice recommendations.To test hypothesis that administration of poudrage during thoracoscopy with local anesthesia more than slurry delivered via chest tube successfully inducing pleurodesis.Open-label, randomized clinical trial conducted at 17 UK hospitals. A total 330...
The definitive diagnosis of pleural malignancy depends upon histological confirmation by biopsy. CT is reported to have a high sensitivity and specificity for the malignant disease, part routine diagnostic workup these patients. aim this study was assess in detecting prior histology obtained via thoracoscopy large cohort patients with suspected disease. Retrospective review thoracoscopies between January 2008 2013 at two UK tertiary referral centres: Oxford Preston. results were compared...
Background Over 30% of adult patients with pleural infection either die and/or require surgery. There is no robust means predicting at baseline presentation which will suffer a poor clinical outcome. A validated risk prediction score would allow early identification high-risk patients, potentially directing more aggressive treatment thereafter. Objectives To prospectively assess previously described (the RAPID (Renal (urea), Age, fluid Purulence, Infection source, Dietary (albumin)) score)...
BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as in children (MIS-C) emerged April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess effect of intravenous immunoglobulin or corticosteroids compared usual care on duration hospital stay for PIMS-TS and compare tocilizumab (anti-IL-6 receptor monoclonal antibody) anakinra (anti-IL-1 antagonist) those inflammation refractory initial treatment.MethodsWe...
Introduction Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease a poor prognosis. Treatment approaches focus on symptom relief optimising quality of life (QoL). Patients who newly present commonly require procedural intervention for both diagnosis therapeutic benefit. Thoracoscopic biopsies are highly sensitive diagnosing malignancy. Talc poudrage may be delivered at thoracoscopy (TTP) to...
Medical thoracoscopy is a valuable tool in the investigation and management of pleural disease. It has considerable advantages over conventional blind biopsy video-assisted thoracoscopic surgery. Despite this, practice this technique UK limited. Most operators use rigid thoracoscope, which may be an unfamiliar instrument to respiratory physicians. A semirigid thoracoscope available but its not been possible as it requires sterilisation with ethylene oxide, approved country. The present...
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in (NCT04381936, ISRCTN50189673). In this assessment DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard care alone or plus DMF. The primary outcome was clinical...
Diagnosing COVID-19 and treating its complications remains a challenge. This review reflects the perspective of some Dragon (IMI 2-call 21, #101005122) research consortium collaborators on utility bronchoalveolar lavage (BAL) in COVID-19. BAL has been proposed as potentially useful diagnostic tool to increase diagnosis sensitivity. In both critically ill non-critically patients, relevant role detecting other infections or supporting alternative diagnoses can change management decisions up...
Medical thoracoscopy has an important place in the diagnosis and management of pleural disease. However, application this procedure is limited United Kingdom. This may be partly because respiratory physicians remain unfamiliar with standard rigid instruments. semirigid variant, popular Europe Japan, similar design to commonly used flexible bronchoscope. The larger biopsy size obtained conventional thoracoscope been quoted as a reason for its superiority. To compare histologic yield 2...
Background Chylothorax is an uncommon medical condition for which limited data are available regarding the contemporary aetiology, management and outcomes. The goal of this study was to better define these poorly characterised features. Methods records adult patients diagnosed with chylothorax at 12 centres across Europe, America South Africa from 2009–2021 were retrospectively reviewed. Descriptive inferential statistics performed. Results 77 (median age 69 years, male female ratio 1.5)...
Introduction Lung volume reduction surgery (LVRS) and endobronchial valve (EBV) placement can produce substantial benefits in appropriately selected people with emphysema. The UK Volume Reduction (UKLVR) registry is a national multicentre observational study set up to support quality standards assess outcomes from LVR procedures at specialist centres across the UK. Methods Data were analysed for all patients undergoing an procedure (LVRS/EBV) who recruited into participating between January...
Background and Objective Pleural effusion of undetermined etiology (PEUE), where blind pleural aspirate/biopsy fails to yield an answer, often needs histologic study for a definitive diagnosis. Several studies have shown the potential utility medical thoracoscopy (MT) in PEUE; results, however, are not uniform majority available rigid thoracoscopy. We sought determine diagnostic accuracy relatively new technique semirigid PEUE through this systematic review. Methods The electronic search was...