A5073678599- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Malaria Research and Control
- Respiratory viral infections research
- Radiomics and Machine Learning in Medical Imaging
- Mosquito-borne diseases and control
- Head and Neck Cancer Studies
- Trauma Management and Diagnosis
- Radiology practices and education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiation Dose and Imaging
- Pneumonia and Respiratory Infections
- Vector-borne infectious diseases
- Congenital Diaphragmatic Hernia Studies
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pericarditis and Cardiac Tamponade
- Respiratory Support and Mechanisms
- Amoebic Infections and Treatments
- Health Promotion and Cardiovascular Prevention
- Tuberculosis Research and Epidemiology
University Hospitals Plymouth NHS Trust
2016-2025
University of Plymouth
2024-2025
Plymouth Hospital
2015-2024
Derriford Hospital
2018-2024
University of St Andrews
2021
Universiti Malaysia Sarawak
2009-2020
London School of Hygiene & Tropical Medicine
2020
National Health Service
2020
Stoke Mandeville Hospital
2009-2014
University Hospital Galway
2013
Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies naturally acquired infections.In systematic study the presentation and course patients with acute P. infection, laboratory data were collected from previously untreated, nonpregnant adults admitted to hospital polymerase chain reaction-confirmed at Kapit Hospital (Sarawak, Malaysia) July 2006 through February 2008.Of 152 recruited, 107 (70%) had...
Background Over 30% of adult patients with pleural infection either die and/or require surgery. There is no robust means predicting at baseline presentation which will suffer a poor clinical outcome. A validated risk prediction score would allow early identification high-risk patients, potentially directing more aggressive treatment thereafter. Objectives To prospectively assess previously described (the RAPID (Renal (urea), Age, fluid Purulence, Infection source, Dietary (albumin)) score)...
Introduction Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence CAO in cancer patients unknown. We audited burden to inform our local service. Methods This cohort review all new diagnoses between 1 November 2014 and 30 2015. was defined by CT appearance. scans routine patient records were followed up 2018 determine the at diagnosis; characteristics with prevalent CAO; mortality (using survival analysis); incident over follow-up. Results Of 342...
Abstract Background Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment malaria man whether antimalarial resistance occurs. Methods A prospective observational study oral chloroquine primaquine therapy was conducted consecutive patients admitted Kapit Hospital, Sarawak, Malaysian Borneo with PCR-confirmed single P. infections. These were given for three days, at 24 hours...
Seldinger Chest Tube Insertion (CTI) is a high acuity low occurrence procedure and remains core capability for UK physician higher speciality trainee's (HST). A multitude of factors have emerged which may affect the opportunity generalists to perform CTI. In view which, this paper sought establish current experiences, attitudes, training, knowledge medical HST performing CTI in acute care hospitals Peninsula deanery.
Point of care ultrasound (POCUS) has revolutionised modern day medicine and widespread utilisation throughout healthcare settings. Despite the availability ultrasounds, there are no requirements for internal trainees (IMTs) to undergo any form POCUS training. This study aimed explore perceptions experience IMTs POCUS. A multicentre survey was distributed via mass email all (IMT1-ST8) across two deaneries in Southwest England. total 42% (213/509) completed survey. Of these 97% (207/213)...
Background Respiratory viral infections (RVIs) are a significant cause of morbidity and hospital admission worldwide. However, the management most infection-associated diseases remains primarily supportive. The recent COVID-19 pandemic has underscored urgent need for deeper understanding RVIs to improve patient outcomes develop effective treatment strategies. Understanding Infection, Viral Exacerbation Symptoms at Admission-Longitudinal Study is an observational study which addresses this by...
Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired malaria is newly described with relatively little available data, including data on host response to infection. Therefore pre-treatment cytokine and chemokine profiles were determined for 94 P. knowlesi, comparison, 20, vivax 22 falciparum, patients recruited in Malaysian Borneo. Nine, five one patient falciparum respectively had complicated as defined by World Health Organisation. Patients...
Abstract Population genetic analysis revealed that Plasmodium knowlesi infections in Malaysian Borneo are caused by 2 divergent parasites associated with long-tailed (cluster 1) and pig-tailed 2) macaques. Because the transmission ecology is likely to differ for each macaque species, we developed a simple genotyping PCR efficiently distinguish between survey parasite subpopulations. This assay confirmed differences relative proportions areas of Kapit division Sarawak state, consistent...
The delivery of a modern cancer service is dependent on the nurse specialist occupying central role in overall pathway. However, there are significant variations access to lung clinical (CNS) across UK and USA. In UK, CNS plays pivotal high-quality care treatment patients with (presumed) thoracic malignancy. They an ideal position provide holistic cancer—ensuring that all needs addressed from time initial referral commencement definitive or palliative care. addition provides support advice...
IntroductionMalignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate blood biomarker could prompt specialist referral or be deployed in future screening. In earlier retrospective studies, SOMAscan proteomics (Somalogic, Boulder, CO) and fibulin-3 seemed highly accurate, but has not been validated prospectively subsequent data have contradictory.MethodsA multicenter prospective observational study was performed 22 centers, generating a large intention-to-diagnose cohort....
Based on expert opinion, the length of antibiotic treatment for pleural infection in adults is typically recommended to be a minimum 4 weeks. This clinical trial aimed assess whether shorter courses lead more failures than standard longer courses.In an open-label randomised controlled trial, adult patients with who were medically treated and stabilised within 14 days admission either short course (total 14-21 days) or long 28-42 days). Patients excluded if their baseline RAPID score was >4...
<b><i>Background:</i></b> Cervical lymph nodes are frequently involved in patients with lung cancer and indicate inoperability. Some guidelines recommend neck ultrasound (NUS) bulky mediastinal lymphadenopathy. Positron emission tomography (PET) is indicated for potentially curable disease. <b><i>Objectives:</i></b> We aimed to assess the diagnostic yield of NUS accuracy PET cervical lymphadenopathy this group a high pre-test probability N3...
Abstract Plasmodium knowlesi , a simian malaria parasite responsible for all recent indigenous cases of in Malaysia, infects humans throughout Southeast Asia. There are two genetically distinct subpopulations Malaysian Borneo, one associated with long-tailed macaques (termed cluster 1) and the other pig-tailed (cluster 2). A prospective study was conducted to determine whether there were any between-subpopulation differences clinical laboratory features, as well epidemiological...