A5062169231- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Music Therapy and Health
- COVID-19 Clinical Research Studies
- Innovations in Medical Education
- Hematological disorders and diagnostics
- Smoking Behavior and Cessation
- Amoebic Infections and Treatments
- Autophagy in Disease and Therapy
- Iron Metabolism and Disorders
- Infectious Diseases and Tuberculosis
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Clinical Reasoning and Diagnostic Skills
- Pneumothorax, Barotrauma, Emphysema
- High Altitude and Hypoxia
- Trauma Management and Diagnosis
- Asthma and respiratory diseases
- Phagocytosis and Immune Regulation
- Air Quality and Health Impacts
Alexandria University
2017-2024
Imperial College London
2021-2024
Harefield Hospital
2024
Royal Brompton & Harefield NHS Foundation Trust
2020-2022
Objectives Lung cancer screening programmes offer an opportunity to address tobacco dependence in current smokers. The effectiveness of different approaches smoking cessation this context has not yet been established. We investigated if immediate support, including pharmacotherapy, offered as part a lung programme, increases quit rates compared usual care (Very Brief Advice and signposting services). Materials methods conducted single-blind randomised controlled trial smokers aged 55–75...
Summary Iron is central to multiple biological pathways, and treatment of non‐anaemic absolute iron deficiency (NAID) beneficial in certain conditions. However, it unknown if NAID associated with increased mortality older adults. A nationally representative sample 4451 adults from the English Longitudinal Study Ageing was used. defined as serum ferritin < 30 μg/l haemoglobin ≥ 120 g/l (women) or 130 (men). Cumulative estimated by Kaplan–Meier method. Unadjusted adjusted hazard ratios...
Based on expert opinion, the length of antibiotic treatment for pleural infection in adults is typically recommended to be a minimum 4 weeks. This clinical trial aimed assess whether shorter courses lead more failures than standard longer courses.In an open-label randomised controlled trial, adult patients with who were medically treated and stabilised within 14 days admission either short course (total 14-21 days) or long 28-42 days). Patients excluded if their baseline RAPID score was >4...
Background Singing for lung health (SLH) is an arts-based breathing control and movement intervention people with long-term respiratory conditions, intended to improve symptoms quality of life. Online, remotely delivered programmes might accessibility; however, no previous studies have assessed the effectiveness this approach. Methods We conducted assessor-blind randomised controlled trial comparing impact 12 weeks once-weekly online SLH sessions against usual care on health-related life,...
Smokers without airflow obstruction have reduced exercise capacity, but the underlying physiological mechanisms are not fully understood. We aimed to compare quadriceps function assessed using nonvolitional measures and ventilatory requirements during exercise, between smokers airway never-smoker controls. Adult (n = 20) controls 16) aged 25-50 yr with normal spirometry, underwent incremental cycle cardiopulmonary testing exhaustion measurement of symptoms dynamic lung volumes. Quadriceps...
Hypoxemia is associated with more severe lung disease and worse outcomes. In some patients chronic obstructive diseases who desaturate on exertion, supplemental oxygen improves exercise capacity. The clinical significance of this response to supplementation not known.We identified at our center underwent a 6-minute walking test (6MWT) for ambulatory assessment desaturated breathing air therefore had an additional walk oxygen, between August 2006 June 2016. Responders were defined as ≥26 m...
<b>Background:</b> Irrigation of the pleural space using an antiseptic solution is used in persistent post thoracotomy infection. This study aimed at assessing safety and efficacy irrigation (API) adult patients with acute infection without prior history surgery. <b>Methods:</b> API involved applying 200-250 ml 2% povidone iodine twice daily for two days undergoing chest tube drainage. Thoracic suction was not routinely used. Data were compared to a similar cohort as control. All data...
<b>Background:</b> Diffuse parenchymal lung diseases (DPLD) is a heterogenous group of disorders with variable presentations and prognoses. Early assessment identification markers severity paramount. <b>Aims:</b> We aimed to assess ultrasound (LUS) as diagnostic tool marker along oxygen desaturation (SpO2) correlate findings chest HRCT other physiologic parameters. <b>Methods:</b> This observational study recruited 31 DPLD patients 20 healthy controls from tertiary care university hospital....
<b>Background:</b> Oxygen is indicated for the treatment of resting severe hypoxemia in patients with lung disease. The impact ambulatory oxygen, administered to prevent desaturation during exercise, less clear, as significance presence or absence an improvement exercise capacity supplemental oxygen. <b>Methods:</b> We identified all at our centre who underwent a six-minute walking test O2 assessment between August 2006 and June 2016, desaturated breathing air therefore had additional walk...
Abstract Background and objective: The optimal length of antibiotic treatment for pleural infection in adults is not known but a minimum four weeks typically recommended. This clinical trial aimed to assess whether shorter courses lead more failures than standard longer courses. Methods: In an open-label randomised controlled adult patients with who were medically treated stabilised within 14 days admission either short course (total 14-21 days) or long 28-42 days). Patients excluded if...
<h3>Background</h3> Singing for Lung Health (SLH) is an arts-based non-pharmacological intervention people with long-term respiratory conditions that aims to improve symptoms and quality of life (QOL). Current research suggests face-to-face SLH can aspects QOL physical performance. There interest in online, remotely delivered SLH, however no previous studies have assessed its impact. <h3>Methods</h3> A single blind randomised controlled trial comparing the impact 12 weeks once-weekly online...
<b>Background:</b> variation in the microbiology of pleural infection by regions is recognised, but there paucity data from Africa and Middle East. This study aimed to examine aspects adult a tertiary centre Egypt. <b>Methods:</b> prospective enrolling adults with collected results standard culture fluid addition cultures biopsies, sputum and/or blood cultures. <b>Results:</b> 60 patients were enrolled over year (80% males, mean age: 43.2). 83% infections community acquired (CA) & 17%...
<h3>Background</h3> Expert opinion recommends treating pleural infection with at least 4 weeks (and up to 6 weeks) of antibiotics and stronger evidence is required guide management. We aim in this trial investigate whether shorter durations antibiotic therapy are as effective (standard) longer courses. <h3>Methods</h3> The short vs long course for management (SLIM) randomised open-label aims recruit 50 patients 1:1 receive a (total duration 2–3 weeks, group A) or (4–6 B) antibiotics....