A5011359629- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Vibrio bacteria research studies
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Nail Diseases and Treatments
- HIV-related health complications and treatments
- Salmonella and Campylobacter epidemiology
- Immune Response and Inflammation
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Yersinia bacterium, plague, ectoparasites research
- HIV Research and Treatment
- Methemoglobinemia and Tumor Lysis Syndrome
- Diphtheria, Corynebacterium, and Tetanus
Patan Academy of Health Sciences
2020-2025
Southern Illinois University School of Medicine
2012-2023
Nepal Health Research Council
2020-2022
Grinnell College
2020
University of Nebraska Medical Center
2017
Memorial Medical Center Foundation
2014
Musculoskeletal Transplant Foundation
2014
University of Illinois at Springfield
2005
Mayo Clinic in Arizona
2004
University of Illinois Chicago
2000
BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as in children (MIS-C) emerged April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess effect of intravenous immunoglobulin or corticosteroids compared usual care on duration hospital stay for PIMS-TS and compare tocilizumab (anti-IL-6 receptor monoclonal antibody) anakinra (anti-IL-1 antagonist) those inflammation refractory initial treatment.MethodsWe...
ObjectivesWe evaluated the prevalence of multidrug resistance (MDR) and production extended spectrum beta-lactamase (ESBL) by Salmonella enterica (serotypes Typhi Paratyphi A) in a teaching hospital Nepal. The MDR strains S. were also tested for susceptibility to newer antibiotics.MethodsBlood cultures obtained from 4105 patients with febrile illnesses. Isolates serotyped antibiotic testing was carried out using disk diffusion (Kirby–Bauer) E-tests. ESBL screening phenotype confirmation done...
Objectives: Although noninvasive positive pressure ventilation is increasingly used for respiratory distress, there not much data supporting its use in children with status asthmaticus. The objective of this study was to determine safety, tolerability, and efficacy early initiation addition standard care the management admitted Study Design: A prospective, randomized, controlled, clinical trial. Patients: Twenty patients (1–18 yrs old) pediatric intensive unit Methods Main Results: Children...
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk CKD, but prior studies lack information on potential mechanisms. We evaluated the association between HCV or hepatitis B (HBV) progressive CKD among 3,441 antiretroviral-treated clinical trial participants. Progressive was defined as composite end-stage renal disease, death, significant glomerular filtration rate...
Abstract Background Enteric fever is an endemic problem in Nepal and Widal agglutination test widely used for its diagnosis but a normal baseline titer healthy population cutoff values have not been established. Methods We measured average antibody titers against "O" "H" antigens of Salmonella enterica serotype Typhi serotypes Paratyphi A B among apparently blood donors Nepal. The were using Standard Confirmatory Quantitative Tube test. Results Among the 100 samples collected from...
In collaboration with a host country and international medical volunteers, PICU an NICU were conceptualized realized in the developing of Nepal. We present here challenges that encountered during after establishment these units. The decision to develop ICU reasonable goals has be made careful assessments need patient population ethical principles guiding appropriate use limited resources. Considerations unit design include space allocation, supply electricity, oxygen source, clean-water...
Abstract Background Dengue caused a large outbreak in Nepal with over 54,000 reported cases 2022. Once considered disease of tropics, dengue has expanded to subtropical and temperate regions including Kathmandu valley. A standard protocol, which included screening criteria for admission treatment based on severity, was adopted at our hospital is located the epicenter 2022 outbreak. Methods We enrolled 261 patients admitted Patan Academy Health Sciences between August October, analyzed...
Objective: This study aims to describe the effect of 0.9% saline (NS) versus 0.45% (half NS) when used during recovery phase diabetic ketoacidosis (DKA) in children. Methods: A retrospective analysis all children (1-18 years old) with DKA admitted pediatric intensive care unit (PICU) from 2005 2009 was undertaken. The primary end point on serum electrolytes and acidosis. Results: Compared 47 patients who received only NS (group A) throughout period 33 but were switched half B) at some...
Summary. Many patients with chronic hepatitis C (HCV) infection undergoing treatment pegylated interferon‐alpha (PEG‐IFN‐alpha) and ribavirin develop neutropenia requiring dose reduction or granulocyte colony‐stimulating factor (G‐CSF) supplement. We analysed the database of who completed for HCV between 2003 2006. Patients absolute neutrophil counts below 1000 cells/ μ L were initiated on G‐CSF (G‐CSF group) while a matching group received anti‐HCV without developing used as control...
Objective: Analysis of hospitalization data can help elucidate the pattern morbidity and mortality in any given area. Little exist on critically ill children admitted to hospitals resource-limited nation Nepal. We sought characterize profile, management, one PICU. Design: Retrospective analysis. Setting: A newly established PICU Patients: All patients between ages 0 16 years from July 2009 2010. Interventions: None. Measurements Results: In 12 months, 126 were including 43% female patients....
Abstract Background Convalescent plasma therapy (CPT) and remdesivir (REM) have been approved for investigational use to treat coronavirus disease 2019 (COVID-19) in Nepal. Methods In this prospective, multicentered study, we evaluated the safety outcomes of treatment with CPT and/or REM 1315 hospitalized COVID-19 patients over 18 years 31 hospitals across was administered moderate, severe, or life-threatening infection. severe infections who were at high risk progression clinical worsening...
Recent data suggest an increased risk for infection when acellular dermal matrix is used in breast reconstruction. This may be because some matrices are actually not terminally sterilized but instead "aseptically processed." study evaluates aseptic and sterile evidence of bacterial contamination whether or terminal sterilization affects collagen architecture stem cell ingrowth.Five separate samples 14 different were analyzed by fluorescent situ hybridization using a DNA probe to detect on...
<i>Clostridium difficile</i> infection is the most common infectious cause of healthcare-acquired diarrhoea. Severe infections therapeutic challenges for healthcare providers. Various novel treatment modalities are currently being explored severe disease. The authors report a 70-year-old female who presented to emergency room with 1 week history fever, watery diarrhoea, diffuse abdominal pain and weakness. <i>C toxin was detected in stool CAT scan showed extensive colonic wall thickening....
Objective. Clostridium difficile infection is an increasingly common cause of healthcare-acquired diarrhea. There remains substantial morbidity and mortality, even with current modalities treatment. The aim our study was to investigate the role intravenous immunoglobulin (IVIG) on mortality in patients severe difficile-associated diarrhea (CDAD). Methods. A retrospective chart review 21 CDAD treated IVIG affiliated hospitals from January 2000 December 2012 conducted. As a matching control...