A5042914476- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Syphilis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- HIV/AIDS Impact and Responses
- COVID-19 Clinical Research Studies
- Hemophilia Treatment and Research
- Reproductive tract infections research
- Data-Driven Disease Surveillance
- Neonatal and Maternal Infections
- COVID-19 impact on air quality
- Facial Nerve Paralysis Treatment and Research
- Chronic Kidney Disease and Diabetes
- Sex work and related issues
- Labour Market and Migration
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Ultrasound Imaging and Elastography
Wroclaw Medical University
2012-2025
Immune Regulation (United Kingdom)
2024
Nicolaus Copernicus University
2023
University of Pittsburgh
2022
Jagiellonian University
2018
IBSS BIOMED (Poland)
2015
Sanofi (France)
2015
MSD (France)
2015
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk CKD, but prior studies lack information on potential mechanisms. We evaluated the association between HCV or hepatitis B (HBV) progressive CKD among 3,441 antiretroviral-treated clinical trial participants. Progressive was defined as composite end-stage renal disease, death, significant glomerular filtration rate...
The Russian invasion of Ukraine forced migration for safety, protection, and assistance. Poland is the primary sheltering country Ukrainian refugees, providing support including medical care, which resulted in rapid ∼15% increase number followed-up people with human immunodeficiency virus (HIV) (PWH) country. Here, we present national experience on HIV care provided refugees from Ukraine.Clinical, antiretroviral, immunological, virologic data 955 PWH entering since February 2022 were...
Air pollution can adversely affect the immune response and increase severity of viral disease. The present study aimed to explore relationship between symptomatology, clinical course, inflammation markers adult patients with coronavirus disease 2019 (COVID-19) hospitalized in Poland (n = 4432) air levels, i.e., mean 24 h max level benzo(a)pyrene (B(a)P) particulate matter <10 μm (PM10) <2.5 (PM2.5) during a week before their hospitalization. Exposures PM2.5 B(a)P exceeding limits were...
Percutaneous liver biopsy is one of the most important and widely used methods for diagnosing chronic diseases; however, controversies related to potential risk complications patient discomfort still exist.The objective this study was evaluate safety success rate blind percutaneous biopsy.We conducted a retrospective analysis 1412 thick-needle biopsies performed during 1977-2000 at single center on 1110 patients, using archived medical data center.The overall obtaining sample with method...
The aim of this study was to assess the mean value spleen stiffness measured by Shear wave elastography in healthy patients and its dependence on age, sex, dimensions, evaluate repeatability method.The final group included 59 volunteers without any clinical evidence liver disease, portal hypertension, hematological disorders, pathological ultrasonographic findings. Each patient underwent abdominal ultrasound examination spleen.The 16.6 ± 2.5 kPa. In men (N = 25), it 17.3 2.7 kPa, women 34),...
Long-term analyses of demographical and clinical characteristics COVID-19 patients can provide a better overview the course disease. They also help understand whether changes in infection symptomatology, disease severity, outcome occur over time. We aimed to analyze demographics, early symptoms infection, laboratory parameters, manifestation hospitalized during first 17 months pandemic Poland (March 2020–June 2021). The patients’ data (n = 5199) were extracted from national SARSTer database...
Abstract The human immunodeficiency virus type 1 (HIV‐1) A6 sub‐subtype is highly prevalent in Eastern Europe. Over the past decade, dissemination of lineage has been expanding Poland. recent Russian invasion Ukraine may further escalate spread this sub‐subtype. While evolutionary studies using viral sequences have instrumental identifying HIV epidemic patterns, origins, and dynamics Poland remain to be explored. We analyzed 1185 HIV‐1 pol from Poland, along with 8318 publicly available...
Objectives The efficacy of pre-exposure prophylaxis (PrEP) relies on adherence to effective regimens. As data real-life PrEP roll-out and from Central Eastern Europe are scarce, we explored the HIV incident infections among users in an observational cohort Poland. Methods A 887 men having sex with (MSM) generic emtricitabine/tenofovir disoproxil (FTC/TDF) were followed for a cumulative 2587 person years (PY). infection was confirmed using molecular immunoassays, subtype genotyping performed...
Background/Objective: HIV remains a significant public health issue in Poland, with many diagnoses occurring at advanced stages due to the limited access diagnostic tools primary healthcare (PHC). General practitioners are crucial for early detection, but barriers such as absence of rapid testing PHC settings hinder timely diagnosis. This study evaluates care physicians’ knowledge diagnostics and pre-exposure prophylaxis (PrEP), focusing on their role improving prevention detection. Material...
The HIV (Human Immunodeficiency Virus) epidemic remains a significant public health issue, requiring ongoing access to preventive methods. This study aimed analyze the evolution of in Lower Silesia from 2010 2020, focusing on key populations. A retrospective analysis medical records newly diagnosed patients at major clinic Wroclaw was conducted, examining demographic data, infection routes, and laboratory results. An 84% increase cases observed over decade, with most common route being sex...
Background: War in Ukraine has forced migration for safety, protection and assistance, including medical care.So far >10 million border crossings to the neighbour countries were registered, with Poland being primary refugee sheltering country over 1.2 Ukrainian refugees registered scheme.HIV disease burden is disproportionately high approximately 0.6% prevalence ∼130 000 antiretroviral (ARV) treated compared ∼0.1% ∼15 people on ARV as of March 2022.Since beginning war 2252 migrants entered...
The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management epidemic worldwide. A cross-sectional analysis 833 treatment-naive patients from 9 17 Polish HIV treatment centres. Partial pol sequences were used to analyse with general time reversible (GTR)-based maximum likelihood algorithm for cluster/pair identification. Mutation frequencies investigated. t-DRMs observed 9%...
The prevalence of HCV infection in people with hemophilia is substantially higher than that the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk HBV HIV transmission. However, other blood-borne viral infections this less well known.This study aimed assess co-infection viruses Polish HCV-infected hemophiliacs.Seventy-one individuals, majority whom were male (94.36%), who had congenital bleeding disorders (60 A, five B, six...
Hepatitis C virus (HCV) is a primarily hepatotropic virus, but hepatocytes are not the only localization of its replication. It still unclear if extrahepatic HCV replication, measured as detection RNA negative strand in peripheral blood mononuclear cells (PBMCs) before initiation treatment, has an influence on therapy response. Detection sites for assessment efficacy routinely used clinical practice. The aim study was to evaluate whether replication PBMCs affects rate sustained virological...
Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting WHO target in most clinical settings. The aim of this study was analyse treatment efficacy Poland and identify variables associated suppression.ethods Cross-sectional data on 5152 (56.92% countrywide treated at time-point analysis) patients cART for more than six months least one HIV-RNA measurement 2016 were collected from 14 Polish centres. Patients'...
Hepatitis C virus (HCV) resistance-associated variants (RAVs) have been shown to adversely affect treatment response of direct-acting antivirals. Identifying pre-existing RAVs and transmission networks among HIV/HCV genotype 1 (G1)-infected patients from Poland will assist in shaping surveillance strategies for HCV.NS3 NS5A sequences were obtained samples 112 antiviral-naive G1 (45 G1a 67 G1b), which 74 chronically infected 38 diagnosed with acute hepatitis (AHC). identified using...
Background: Percutaneous liver biopsy is one of the most important and widely used methods for diagnosing chronic diseases; however, controversies related to potential risk complications patient discomfort still exist. Objectives: The objective this study was evaluate safety success rate blind percutaneous biopsy. Patients Methods: We conducted a retrospective analysis 1412 thick-needle biopsies performed during 1977-2000 at single center on 1110 patients, using archived medical data center....
Hepatitis C virus (HCV) is the major cause of chronic liver disease in patients with hemophilia. However, since biopsy should not be routinely used these patients, accurate assessment stage fibrosis has been limited so far.The aim this study was to determine HCV‑infected hemophilia by using noninvasive methods assessment, and analyze influence risk factors on fibrosis.The included 71 other congenital bleeding disorders. Patients were divided into 3 groups: HCV-RNA negative after successful...
The purpose of the study was to assess hepcidin levels and iron metabolism in otherwise healthy human immunodeficiency virus-1 (HIV-1)-infected males influence antiretroviral therapy on production, as data this group are scarce. A total 89 HIV-1-infected males, 42 effective (ART)—group A, 47 treatment-naïve—group B, 27 controls—group C, were enrolled. Erythrocytes parameters, hepcidin, highly sensitive C-reactive protein (hsCRP), interleukin 6 (IL-6), soluble transferrin receptor (sTfR)...
Introduction In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) driven by transmissions among men‐who‐have‐sex‐with‐men (MSM). The number of new cases increased in recent years, while no current data on transmitted resistance associated mutations (tDRM) frequency trend over time are available 2010. this study, we analyze temporal trends spread tDRM 2008 2013. Materials and Methods Partial pol sequences 833 antiretroviral...
comorbidities and minimizing the side effects of antiretroviral drugs.The first reports kidney disease in patients with acquired immunodeficiency syndrome (AIDS) caused by HIV-1 date back to mid-1980s. [1]2][3] It was proved then for time that can infect epithelial cells kidney. 4 Later, it shown there are many other INTRODUCTION Wide access effective combined therapy (cART) increasingly better virological immunological control human virus 1 (HIV-1) infection results continuous improvement...