A5018290358- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- HIV-related health complications and treatments
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Vector-borne infectious diseases
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- Liver Diseases and Immunity
- Pneumocystis jirovecii pneumonia detection and treatment
- Tryptophan and brain disorders
- Diabetes and associated disorders
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Infections and Vaccines
- Diet and metabolism studies
- Blood groups and transfusion
- Gastrointestinal motility and disorders
- Polyomavirus and related diseases
Medical University of Warsaw
2015-2024
Institute of Physiology and Pathology of Hearing
2018
Bipar
2017
Gdańsk Medical University
2016
St. Joseph's Hospital and Medical Center
2007
Mayo Clinic in Arizona
2000-2005
Academy of Medical Sciences
2002-2005
SC Johnson (United States)
2004
University of Southern California
2000
University of Pittsburgh Medical Center
1997-1999
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV) infection results in complete elimination of virus, or small quantities persist. Our study group comprised 17 patients with HCV who had sustained virological response (SVR) after interferon/ribavirin treatment. Serum and peripheral blood mononudear cells were collected 2 to 3 times at 3- 6-month intervals starting 40 109 months (mean, 64.2 +/- 18.5 months) end therapy. In addition, lymphocyte macrophage...
ABSTRACT Patients with chronic hepatitis C are more likely to have significant changes in their physical and mental well-being than patients liver disease of other etiology, virus (HCV) has been occasionally implicated diseases the central nervous system. We analyzed presence HCV negative-strand RNA sequence, which is viral replicative intermediary, autopsy brain tissue samples from six HCV-infected patients. Negative-strand was searched for by a strand-specific Tth -based reverse...
It has been reported that hepatitis C virus (HCV) may be lymphotropic in the setting of human immunodeficiency type 1 (HIV-1) coinfection. The present study was undertaken to determine phenotype lymphoid cells harboring replicating HCV HIV-1-positive subjects. By means highly strand-specific thermostable enzyme Tth-based reverse-transcriptase polymerase chain reaction, presence viral RNA-negative strand sought different subpopulations peripheral blood mononuclear from 10 HIV-positive...
Hepatitis C virus (HCV) infection often is associated with cognitive dysfunction and depression. HCV sequences replicative forms were detected in autopsy brain tissue cerebrospinal fluid from infected patients, suggesting direct neuroinvasion. However, the phenotype of cells harboring remains unclear. We studied 12 HCV-infected 6 whom coinfected human immunodeficiency virus. Cryostat sections frontal cortex subcortical white matter stained monoclonal antibodies specific for...
The present organ shortage has brought into question the suitability of hepatitis C virus (HCV)-positive grafts. This study reviewed outcome such transplantations in our institution.Twenty-three HCV-positive patients who underwent orthotopic liver transplantation (OLT) for end-stage disease with grafts 1992-1995 were studied. Only survived more than 30 days included analysis. Control group 169 HCV-related cirrhosis and received HCV-negative organs.Patients HCV-infected organs had a...
The existence of extrahepatic reservoirs hepatitis C virus (HCV) replication remains highly controversial. We searched for the presence HCV-RNA negative strand in various tissues from eight HCV-infected patients who died acquired immunodeficiency syndrome (AIDS)-related complications. Negative-strand RNA was detected by a Tth-based reverse-transcriptase polymerase chain reaction (RT-PCR), which optimized sensitivity and specificity on synthetic templates. This assay capable detecting about...
Hepatitis C virus (HCV) sequences were detected in cerebrospinal fluid (CSF) 8 of 13 HCV-positive patients. In four patients harboring different strains serum and peripheral blood mononuclear cells (PBMC), CSF-derived was similar to that found PBMC, which suggests PBMC could carry HCV into the brain.
The pathogenic implications of hepatitis G virus (HGV) infection are still unclear. We searched for the presence HGV RNA and HCV sequences in liver serum samples from 10 patients with chronic disease, 9 whom were coinfected HCV. All livers negative minus strand only six positive strand, albeit at low levels. In striking contrast, was detectable all nine HCV-positive titers ranging 10(2) to 10(8) genomic eq/microg RNA, present but two these patients. However, positive-strand viruses had...
<h3>Objectives</h3> Hepatitis C virus (HCV) infection is commonly associated with cognitive dysfunction. Viral sequences and proteins were previously found in brain macrophage/microglia cells. The aim of the current study was to determine whether HCV affects expression key cytokines chemokines these <h3>Methods</h3> Autopsy tissue from 15 patients studied; 7 positive 8 negative. Cryostat sections frontal cortex subcortical white matter stained monoclonal antibodies specific for...
Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently common cause of viral brain many countries. Encephalitis transplant recipients, althrough rare, becoming recognized complication. Our study provides the first description transmission TBEV through transplantation solid organs.Three patients who received organ transplants from single donor (2 kidney, 1 liver) developed 17-49 days after subsequently died. Blood autopsy tissue samples...
Dermacentor reticulatus plays an important role in the maintenance of pathogens medical and veterinary importance environment. Currently two isolated populations D. are present Poland--Western Eastern. The range Eastern population covers endemic areas eastern Poland but this is expanding westwards creating expansion zone centre country. western occupied by recently discovered Western population, spreading eastwards. Questing adult ticks (n = 2585) were collected 2012-2014 regions...
The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It estimated that human colonized by up 1018 microorganisms, mostly anaerobic bacteria. microbiome responsible for multiple functions, e.g. tightness intestine barrier, digestion and absorption. correlation between dysbiosis development psychiatric, autoimmune allergic diseases as well bidirectional communication brain microflora have been shown. Recent findings suggest...
We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues patients with chronic C. These results are compatible existence independent viral compartments infected host. Our also suggest that PBMCs, probably tissues, can selectively adsorb subpopulations differing E2 region.
Encephalitis is a severe neurological syndrome usually caused by viruses. Despite significant progress in diagnostic techniques, the causative agent remains unidentified majority of cases. The aim present study was to test an alternative approach for detection putative pathogens encephalitis using next-generation sequencing (NGS). RNA extracted from cerebrospinal fluid (CSF) 60-year-old male patient with and subjected isothermal linear nucleic acid amplification (Ribo-SPIA, NuGen) followed...
The aim of this study was to report the influence hepatitis C virus (HCV) genotypes and HLA matches on outcome liver transplantation, recurrence, progression cirrhosis after transplantation.HCV were determined from pretransplantation sera and/or explant tissues 202 patients with HCV-related end-stage disease. One hundred fifty known infecting genotype for whom posttransplantation biopsy specimens available or who had normal results injury tests constituted group analyzed. Patients followed...
Hepatitis C virus (HCV) has been reported to replicate in monocytes/macrophages infected patients. However, it is unclear whether macrophages are susceptible infection vitro and such an consequential. Sera from 26 HCV-infected patients were incubated with primary human collected healthy donors. Virus negative strand was detected by a Tth enzyme-based strand-specific assay sequences analysed single conformation polymorphism (SSCP) sequencing. Concentrations of the cytokines tumour necrosis...