A5000603828- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Hemoglobinopathies and Related Disorders
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Hemophilia Treatment and Research
- Labour Market and Migration
- Nutrition and Health Studies
- Erythropoietin and Anemia Treatment
- Public health and occupational medicine
Immune Regulation (United Kingdom)
2024
Wroclaw Medical University
2013-2023
Medical University of Białystok
2021
Jagiellonian University
2018-2021
Sanofi (France)
2015
MSD (France)
2015
IBSS BIOMED (Poland)
2015
Wojewódzki Szpital Zespolony
2014
University of Wrocław
1992-2012
Hospital Universitario Ramón y Cajal
2011
Abstract The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon‐alpha‐based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, A dominant Northern Europe. However, distribution unknown several Central Eastern European countries. Data described 1313 HBsAg‐positive recruited at 14 referral centers eight There were only very few cases B, C, E, F, H infection while D found 42% 48%...
<h3>Background</h3> Tryptophan metabolism via the kynurenine pathway is considered link between immune and endocrine systems. Dysregulation of serotonergic transmission can stem from direct influence interferon-α on activity receptors 5-HT<sub>1A</sub> 5-HT<sub>2A</sub>, its indirect effect tryptophan metabolism. Induction increases concentration neurotoxic metabolites, derivatives linked to onset depression. The aim our study was evaluate relationships depressive symptoms kynurenine,...
Killer cell immunoglobulin-like receptors (KIR) are the most polymorphic of natural killer (NK) cells. Their activity diversifies functions NK cells in antiviral immune response, so presence certain KIR may affect transmission HIV-1. The aim study was to evaluate influence genes on susceptibility HIV-1 infection Polish population depending route exposure. We determined frequencies activating (2DS1, 2DS2, 2DS3, 2DS4f, 2DS4del, 2DS5, 3DS1) and inhibitory (2DL1, 2DL2, 2DL3, 2DL5, 3DL1) KIRs...
Summary. Detection of residual HCV in individuals with SVR after treatment CHC can be significantly heightened by analyzing ex vivo mitogen‐activated T and B lymphocytes applying sensitive nucleic acid amplification assays. However, it remained unknown if synergistic activation monocytes would further augment detection, viral replication becomes universally upregulated treated cells, examining sequential sera lymphoid cells improve detection occult infection. Using paired collected 1 year...
To gain insight into HIV transmission we estimated the proportion of those recently infected. We examined data from HIV-positive patients and a random 10% sample HIV-negative tested at Voluntary Counseling Testing sites in Poland 2006. Archived samples positive were by three assays to differentiate recent long-standing infection. Using logistic regression, association infection (at least one assay) with age, sex, exposure category, interval between self-reported previous test. Of 13,511...
We assessed the prevalence of anti-hepatitis C virus (anti-HCV) antibodies and markers hepatitis B (HBV) infection in patients three haemodialysis centres before initiating anti-HBV vaccinations. Of 94 patients, 39 (41.5%) were anti-HCV positive (+) 81 (86.2%) core antigen (HBc) positive. There was a high rate anti-HBc positivity among (92.3%), although presence not significantly related to each other. Multiple blood transfusions (> 5 units) risk factor for development HCV (P < 0.02), while...
Based on investigations of liver biopsy material, certain cellular genes have been implicated as correlates success or failure to interferon alpha-ribavirin (IFN/RBV) therapy against hepatitis C. The current study aimed at determining whether expression host thought be relevant HCV replication in the would correlated with infection status peripheral blood mononuclear cells (PBMCs) and also patient responsiveness IFN/RBV treatment. Therefore, PBMCs from patients chronic C responding (n = 35)...
Cytokine response against hepatitis C virus (HCV) is likely to determine the natural course of infection as well outcome antiviral treatment. However, role particular cytokines remains unclear. The current study analyzed activation cytokine in chronic patients undergoing standard Twenty-two were treated with pegylated interferon and ribavirin. Twenty-six different transcripts measured quantitatively peripheral blood mononuclear cells (PBMC) before after therapy correlated clinical liver...
The prevalence of HCV infection in people with hemophilia is substantially higher than that the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk HBV HIV transmission. However, other blood-borne viral infections this less well known.This study aimed assess co-infection viruses Polish HCV-infected hemophiliacs.Seventy-one individuals, majority whom were male (94.36%), who had congenital bleeding disorders (60 A, five B, six...
Hepatitis C virus (HCV) is a primarily hepatotropic virus, but hepatocytes are not the only localization of its replication. It still unclear if extrahepatic HCV replication, measured as detection RNA negative strand in peripheral blood mononuclear cells (PBMCs) before initiation treatment, has an influence on therapy response. Detection sites for assessment efficacy routinely used clinical practice. The aim study was to evaluate whether replication PBMCs affects rate sustained virological...
Hepatitis C virus (HCV) resistance-associated variants (RAVs) have been shown to adversely affect treatment response of direct-acting antivirals. Identifying pre-existing RAVs and transmission networks among HIV/HCV genotype 1 (G1)-infected patients from Poland will assist in shaping surveillance strategies for HCV.NS3 NS5A sequences were obtained samples 112 antiviral-naive G1 (45 G1a 67 G1b), which 74 chronically infected 38 diagnosed with acute hepatitis (AHC). identified using...
The aim of the study was to assess importance and usefulness in everyday clinical practice urinary concentrations β-microglobulin (β2M) retinol binding protein (RBP) evaluation renal function HIV-positive patients. Kidney proximal tubule cells are most prone damage for low molecular-weight proteins as sensible markers pathology this part nephron. Urine collected from 86 patients consulted HIV/AIDS Outpatients Clinic Wroclaw. In group with decreased base-line GFR on tenofovir β2M level...
Sepsis-associated liver dysfunction (SALD) is associated with a poor prognosis and increased mortality in the intensive care unit. Bilirubin one of components Sequential Organ Failure Assessment used Sepsis-3 criteria. Hyperbilirubinemia late non-specific symptom dysfunction. This study aimed to identify plasma biomarkers that could be for an early diagnosis SALD. prospective, observational was conducted on group 79 patients sepsis septic shock treated ICU. Plasma biomarkers—prothrombin...
Seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during PEG-IFN-α2a treatment, the aim of current study is to examine (a) polymorphisms within HTR1A, TPH2, 5-HTT genes severity depression symptoms (b) relationships among rs6295, rs4570625, 5-HTTLPR rs25531polymorphisms indoleamine 2,3-dioxygenase (IDO) activity, as well kynurenine (KYN), (TRP), kynurenic acid (KA), anthranilic (AA) concentrations. The followed a...
The replication of vesicular stomatitis virus (VSV) in isolated human leukocytes has been used to measure the level nonspecific antiviral immunity. However, during infection with some pathogens, main effect observed is caused by interaction between pathogen and VSV. This was also noted advanced stages HIV infection, when an inverse association viral load VSV found. mutual markedly stronger than correlation CD4+ T-cell count. Since successful antiretroviral therapy associated a decrease...
Hepatitis C virus (HCV) is the major cause of chronic liver disease in patients with hemophilia. However, since biopsy should not be routinely used these patients, accurate assessment stage fibrosis has been limited so far.The aim this study was to determine HCV‑infected hemophilia by using noninvasive methods assessment, and analyze influence risk factors on fibrosis.The included 71 other congenital bleeding disorders. Patients were divided into 3 groups: HCV-RNA negative after successful...
Since the end of December 2020, it has been possible to vaccinate against COVID-19. Our aim was evaluate and compare effectiveness vaccines available at time mass vaccination program in Poland also look into most common adverse side effects. Patients' anti-SARS-CoV-2 antibodies levels were checked before after first second/last dose by QuantiVac ELISA (IgG) (EUROIMMUN MedicinischeLabordiagnostica AG; Luebeck; Germany) test. Before each blood collection, all patients filled out a...