A5025544148- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Clostridium difficile and Clostridium perfringens research
- Acute Kidney Injury Research
- Nephrotoxicity and Medicinal Plants
- Microscopic Colitis
- Dialysis and Renal Disease Management
- Nosocomial Infections in ICU
- Birth, Development, and Health
- Central Venous Catheters and Hemodialysis
- Erythrocyte Function and Pathophysiology
- Pregnancy and Medication Impact
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Blood groups and transfusion
- Vascular anomalies and interventions
- Drug-Induced Hepatotoxicity and Protection
- Platelet Disorders and Treatments
- Gastrointestinal motility and disorders
- Porphyrin Metabolism and Disorders
- Advanced Glycation End Products research
- Genetic and Kidney Cyst Diseases
- Renal Transplantation Outcomes and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
Łukasiewicz Research Network – PORT Polish Center for Technology Development
2013-2022
Wroclaw Medical University
1985-2022
Wojewódzki Szpital Specjalistyczny we Wrocławiu
2006-2020
Wroclaw Research Centre EIT+ (Poland)
2015-2017
Institute of Clinical and Experimental Medicine
2014
University Hospital Kralovske Vinohrady
2013
Charles University
2013
University of Wrocław
2004
New York Academy of Medicine
1993
Niepubliczna Wyższa Szkoła Medyczna
1992
This is the first report on epidemiology of biopsy-proven kidney diseases in Poland.The Polish Registry Renal Biopsies has collected information all (n = 9394) native renal biopsies performed Poland from 2009 to 2014. Patients' clinical data at time biopsy, and histopathological diagnoses were used for epidemiological clinicopathologic analysis.There was a gradual increase number per million people (PMP) year 2009-14, starting 36 PMP 44 A considerable variability between provinces mean...
Abstract Expression of the inducible form nitric oxide synthase (iNOS) has been found to be up-regulated in cytokine-stimulated mesangial cells (MC) and experimental glomerulonephritis. Since direct toxicity (NO) implicated damage bacteria, neoplastic intact pancreatic cells, we investigated whether NO is cytotoxic cultured MC, which may relevant pathogenesis glomerular injury. MC isolated from rat glomeruli generated substantial amounts nitrite, stable end-product, when were stimulated with...
Since kidney transplant recipients are at enhanced risk for developing severe upper gastrointestinal disease and Helicobacter pylori (Hp) is an important pathogen in active gastritis peptic ulcer, we performed gastroduodenoscopic examination, coupled with assessment of Hp colonization 29 renal allograft complaining recurrent dyspepsia. Results were compared those 25 chronically hemodialyzed patients 16 subjects free from disease, also suffering symptoms similar severity. We found that while...
We assessed the prevalence of anti-hepatitis C virus (anti-HCV) antibodies and markers hepatitis B (HBV) infection in patients three haemodialysis centres before initiating anti-HBV vaccinations. Of 94 patients, 39 (41.5%) were anti-HCV positive (+) 81 (86.2%) core antigen (HBc) positive. There was a high rate anti-HBc positivity among (92.3%), although presence not significantly related to each other. Multiple blood transfusions (> 5 units) risk factor for development HCV (P < 0.02), while...
Clostridium difficile (C. difficile) is a Gram-positive bacillus responsible for diarrhea and colitis, mainly among hospitalized patients. It leading cause of nosocomial infections.The main goal the study was to assess risk factors C. infection in patients with chronic kidney disease (CKD).We evaluated medical records all treated at Department Nephrology Renal Transplantation Research Development Center Provincial Specialist Hospital Wrocław, Poland, between February 2009 May 2012, who...
The majority of recently published studies indicate a greater incidence and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). Hospitalization, older age, the use antibiotics, immunosuppression, proton pump inhibitors (PPI), diseases such as CKD are responsible for increased prevalence infections. aim study is identify clinical indicators allowing, combination artificial intelligence (AI) techniques, most accurate assessment being at...
We have previously documented the importance of tumor necrosis factor (TNF) alpha in pathogenesis nephrotoxic-serum nephritis rats. In this study, we evaluated possible relevance well-established cytocidal TNF activity to mechanism glomerular injury by assessing sensitivity rat mesangial and epithelial cell populations recombinant murine (rMuTNF). Radiolabelled confluent cultures that were incubated with rMuTNF released significantly more 3H-thymidine than control monolayers (maximum...
<p><strong>ABSTRACT</strong><br /><em>Clostridioides difficile</em> infection (CDI) is a leading cause of healthcare-associated diarrhea worldwide. Recently, an increased number new cases and growing mortality due to CDI have been observed. Patients suffering from end-stage renal disease (ESRD) are most exposed CDI. It has proven that in patients receiving replacement therapy (RRT) significantly increases mortality, prolongs hospitalization the cost...
<b><i>Background/Aims:</i></b> A link between the number of podocytes excreted in urine and activity glomerular disease has been established. The aim this study was to investigate possible correlations urinary cells' phenotype progression focal segmental glomerulosclerosis (FSGS). <b><i>Methods:</i></b> Forty patients with newly diagnosed FSGS were included. Cells isolated from by adherence collagen-coated cover slips assessed for expression...
The majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). aim this study was assess the clinical determinants predicting CDI among hospitalized CKD refine methods prevention. We evaluated medical records 279 treated at nephrological department symptoms suggesting CDI, whom 93 tested positive for CDI. survey showed that age, poor function, high Padua prediction score...
Given the evidence accrued by other authors on beneficial effect of protease inhibitors experimental immune nephritis, and following our preliminary report abrogation glomerulopathy in rat antifibrinolytic antiproteolytic drug, epsilon-aminocaproic acid (EACA), we investigated this drug autologous anti-GBM nephritis. Along with EACA evaluated another inhibitor, aprotinin, an antagonist serine proteases.EACA (0.3g/kg) or aprotinin (5000 kallkrein inhibition units, KIU/kg) was administered...
Hess, L.1; Malek, J.2; Kurzova, A.2; Hruby, Z.1; Stein, K.3 VG 20102015014 Author Information
Charles University in Prague and Hospital Kralovske Vinohrady, Dept of Anaesthesiology & Intensive Care, Praha, Czech Republic