A5009262170- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Long-Term Effects of COVID-19
- Malaria Research and Control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Dengue and Mosquito Control Research
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Trypanosoma species research and implications
- Vector-borne infectious diseases
- Antibiotic Use and Resistance
- Bacterial Infections and Vaccines
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Antibiotic Resistance in Bacteria
- COVID-19 Pandemic Impacts
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- Dermatological diseases and infestations
- Heparin-Induced Thrombocytopenia and Thrombosis
Sukraraj Tropical & Infectious Disease Hospital
2017-2025
Government of Nepal
2022
Ministry of Health and Population
2022
Intestinal myiasis is a type of resulting from the accidental consumption Clogmia albipunctata larvae. This generally displays symptoms such as nausea, vomiting, abdominal distention and discomfort, loss appetite, weight loss, intermittent diarrhea. It rare form with relatively scarce literature in Nepal. We report probably first case human intestinal caused by A 39-year-old nondiabetic female, Brahmin belonging to khas/arya ethnicity presented complaints perianal itching, occasional...
Abstract Background: The emergence of antibiotic resistance, particularly plasmid-mediated colistin poses a critical threat to global public health, given colistin’s role as last-resort for treating multidrug-resistant (MDR) bacterial infections. Despite its significance, data on resistance and the prevalence mobile ( mcr ) genes in Nepal are scarce. This study aims investigate occurrence mobilized mcr-1 mcr-2 MDR Escherichia coli isolates from clinical specimens, highlighting burden...
The novel coronavirus COVID-19 (SARS-CoV-2) was first reported in 31 December 2019 Wuhan City, China. case of officially announced on 24 January, 2020, Nepal. Nine cases have been We aim to describe our experiences patients Keywords: COVID-19; experience;
ABSTRACT Acute encephalitis syndrome (AES) causes significant morbidity and mortality worldwide. In Nepal, Japanese virus (JEV) accounts for ~5-20% of AES cases, but ~75% cases are unknown etiology. We identified a gemykibivirus in CSF collected 2020 from an 8-year-old male patient with using metagenomic next-generation sequencing. Gemykibiviruses single stranded, circular DNA viruses the family Genomoviridae . The complete genome 2,211 nucleotides was sequenced, which shared 98.69%...
Abstract Background Dengue cases have been continuously reported in Nepal, including some large outbreaks, since its first introduction 2004. The disease is now expanding towards newer locations above 1400 m high, especially the country's capital city, Kathmandu. In 2019, >14,000 dengue six deaths were reported. This study was aimed at detection and molecular characterization of virus (DENV) patients. Methods A total 451 patients enrolled this study. Demographic, clinical laboratory...
Nepal is an endemic country for dengue infection with rolling of every 3 year's clear cyclic outbreaks exponential growth since 2019 outbreak and the virus gearing towards non-foci temperate hill regions. However, information regarding circulating serotype genotype not frequent. This research discusses on clinical features, diagnosis, epidemiology, among 61 suspected cases from different hospitals during window period 2017-2018 between two 2016 2019. E-gene sequences PCR positive samples...
Abstract COVID‐19 has been associated with several neurological complications. We presented a case of Bell's palsy as possible complication infection. Further research should be conducted to clarify the association, correlation, or causality between and neuroimmunological diseases.
The long-term effects of COVID-19 among survivors is a matter concern. This research aimed to study persistent symptoms in post-COVID-19 patients attending follow-up clinic at tertiary care hospital Nepal. All patients, presenting the outpatient during duration six weeks, with history positive reverse transcriptase- polymerase chain reaction for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) least two weeks prior presentation, were included. ranged from 15 till 150 days mean 28...
Coronavirus Disease 2019 (COVID-19) has challenged the health system worldwide, including low and middle income countries like Nepal. In view of rising number infections prediction multiple waves this disease, mortalities due to COVID-19 need be critically analyzed so that every possible effort could made prevent related in future. Main aim research was study about at a tertiary level hospital, This retrospective, observational included all inpatients from Sukraraj Tropical Infectious...
Scrub typhus is caused by Orientia tsutsugamushi, transmitted through bites of infected chiggers (larval mites). During the coronavirus disease 2019 (COVID-19) pandemic, reports co-infections with endemic pathogens are increasing around world. Disease similar clinical presentation may mask other diagnosis and increase morbidity mortality patients. We report co-infection between severe acute respiratory syndrome 2 (SARS-CoV-2) O. tsutsugamushi in a patient Nepal presenting fever, headache,...
Abstract Background Convalescent plasma therapy (CPT) and remdesivir (REM) have been approved for investigational use to treat coronavirus disease 2019 (COVID-19) in Nepal. Methods In this prospective, multicentered study, we evaluated the safety outcomes of treatment with CPT and/or REM 1315 hospitalized COVID-19 patients over 18 years 31 hospitals across was administered moderate, severe, or life-threatening infection. severe infections who were at high risk progression clinical worsening...
Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and widely reported in USA, Central Europe, South East Asia Latin America. Until recently, no scientific report regarding Nepal had been published.A 32-year-old, previously healthy female visited hospital with history of joint pains, fatigue, neck stiffness, tingling sensation headache. She was initially treated for typhoid fever, brucellosis malaria, but did not show significant improvement. Doxycycline...
Early diagnosis of cryptococcal meningitis among people living with HIV (PLHIV) is crucial for its therapeutic success. The objective this study was to diagnose in PLHIV cases using the available laboratory techniques confirmation resource limited setting. This cross-sectional prospective conducted 72 clinical suspicion meningitis. Each cerebrospinal fluid (CSF) sample received at National Public Health Laboratory, Kathmandu processed India ink staining, antigen lateral flow assay, and...
Backgrounds: Intestinal Parasitic Infection (IPI) plays a vital role in the prognosis of People Living with HIV/AIDS (PLHA).Aims and Objectives: In this study, we aimed to measure prevalence associated factors IPI among PLHA non-HIV patients attending Sukraraj Tropical Infectious Disease Hospital, Teku, Kathmandu.Materials Methods: A cross-sectional study was conducted 193 111 having either gastrointestinal disorders. Direct smear, Formalin ethyl acetate sedimentation Kinyoun’s modified acid...
Dengue treatment and management is challenging during the epidemic especially among risk groups to mitigate risks becomes even more complicated in absence of specific medicine vaccines. Till date, there are no research endeavours Nepal focusing on pregnant women with dengue evident gap concerning due overlapping clinical hematological manifestations physiological changes gestation. The study comprises clinically diagnosed one positive female, five female patients Sukraraj Tropical Infectious...
Abstract Acute Encephalitis Syndrome (AES) causes significant morbidity and mortality worldwide. In Nepal, Japanese encephalitis virus (JEV) accounts for ∼ 5-20% of AES cases, but ∼75% cases are unknown etiology. We identified a gemykibivirus in CSF collected 2020 from male child with using metagenomic next-generation sequencing. Gemykibiviruses single stranded, circular DNA viruses the family Genomoviridae . The complete genome 2211 nucleotides was sequenced which shared 98.69% nucleotide...
In Nepal, over 1 million individuals have tested positive for SARS-CoV-2. We sought to describe the frequency of nonrecovery from this infection at 6 months and associated symptoms. conducted a retrospective cohort study 6142 women who had negative PCR tests previously 3 institutions in Kathmandu. telephone interviews provided information on 22 symptoms their intensities, health status history, functional status. Of 3732 positive, 630 (16.9%) reported that they were unrecovered. These...
The clinical features of COVID-19 are vary widely, ranging from asymptomatic states or mild upper respiratory tract infections to severe pneumonia. Previous studies have shown that 20.0% patients hospitalized, out which 10.0-20.0% admitted the Intensive Care Unit. present study aims assess predictors associated with leading Unit admission among reverse transcriptase- polymerase chain reaction (RT-PCR) positive in Sukraraj Tropical and infectious disease hospital, Nepal. A case-control was...
Abstract Background The 4 serotypes of dengue virus (DENV1-4) can each cause potentially deadly disease, and are spreading globally from tropical subtropical areas to more temperate ones. Nepal provides a microcosm this global phenomenon, having met these grim benchmarks. To better understand DENV transmission dynamics spread into new areas, we chose study in and, so doing, build the onsite infrastructure needed manage future, larger studies. Methods Results During 2022 season, enrolled 384...
ABSTRACT A patient with fever presented to the referral infectious disease hospital in Kathmandu, Nepal. Metagenomic sequencing of patient’s serum recovered a near-complete genome human immunodeficiency virus-1 (HIV-1), distinct from previous HIV-1 genomes Nepal GenBank. It shared 92.48% nucleotide identity an subtype C isolate India.
Abstract Background The 4 serotypes of dengue virus (DENV1-4) can each cause potentially deadly disease, and are spreading globally from tropical subtropical areas to more temperate ones. Nepal provides a microcosm this global phenomenon, having met these grim benchmarks. To better understand DENV transmission dynamics spread into new areas, we chose study in and, so doing, build the onsite infrastructure needed manage future, larger studies. Methods results During 2022 season, enrolled 384...
Acute kidney Injury associated with Coronavirus disease COVID-19 appeared to negatively influence clinical outcomes and is found be significant risk of death. This retrospective study aimed describe the incidence Kidney Injury, its associations characteristics among patients in Sukraraj Tropical Infectious Disease Hospital, a tertiary infectious hospital Nepal. A cross-sectional was done where. Medical lab records reverse transcriptase Polymerase chain reaction positive inpatients, admitted...
An increase in cerebrospinal fluid (CSF) cell count is an indicator of the diagnosis bacterial meningitis. However, studies have reported that few meningitis cases showed no abnormalities initial CSF analysis. Therefore, this study aimed to analyze culture positive cases. A cross-sectional hospital based prospective was conducted from January 2017 December 2018 among 387 samples collected clinically suspected attending different hospitals located Kathmandu, Nepal. Each sample processed for...