A5000079558- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- CRISPR and Genetic Engineering
- Blood Pressure and Hypertension Studies
- Cancer-related Molecular Pathways
- COVID-19 Pandemic Impacts
- HIV-related health complications and treatments
- Physiological and biochemical adaptations
- Trypanosoma species research and implications
- Hepatitis C virus research
- Optimal Power Flow Distribution
- HIV Research and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 and Mental Health
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- Power System Optimization and Stability
- Research on Leishmaniasis Studies
- Vector-borne infectious diseases
- COVID-19 epidemiological studies
- Glycosylation and Glycoproteins Research
Indiana University – Purdue University Indianapolis
2025
Indiana University School of Medicine
2025
New Mexico State University
2022-2024
Tribhuvan University
2018-2021
Multiple myeloma (MM) is an incurable malignancy characterized by mutated plasma cell clonal expansion in the bone marrow, leading to severe clinical symptoms. Thus, identifying new therapeutic targets for MM crucial. We identified oligosaccharyltransferase (OST) complex as a novel vulnerability cells. Elevated expression of this associated with relapsed, high-risk MM, and poor prognosis. Disrupting OST suppressed growth, induced cell-cycle arrest, apoptosis. Combined inhibition bortezomib...
Dengue virus (DENV) infection is endemic in Nepal. Although rates are reported annually, little information available about the circulating viral serotypes and genotypes. Here, we report results of a multicentre cross-sectional study DENV genotypes sampled from individuals with suspected Nepal 2017. Of 50 patients sampled, 40 were serologically positive for NS1, 29 anti-DENV IgM, 21 IgG 14 by qRT-PCR. The three DENV-1, 2 3 detected there was no DENV-4. Positive samples serotyping subjected...
Introduction: COVID-19 infection is caused by a new strain of SARS CoV-2 virus, which transmits directly from person-to-person and has become pandemic. To counteract this, actions related to mass quarantines or stay-at-home orders have been used termed as lockdown. This study aims lifestyle, behaviour, perception practice people regarding during the Methods: An online survey was conducted with structured questionnaire in Google forms after ethical approval Nepal Health Research Council...
Malpighian tubules, the renal organs of mosquitoes, facilitate rapid dehydration blood meals through aquaporin-mediated osmosis. We performed phosphoproteomics analysis three tubule protein-libraries (1000 tubules/sample) from unfed female mosquitoes as well one and 24 hours after a meal. identified 4663 putative phosphorylation sites in 1955 different proteins. Our exploratory dataset reveals meal-induced changes patterns many subunits V-ATPase, proteins target rapamycin signaling pathway,...
The amino acid transporter protein cationic 1 (CAT1) is part of the nutrient sensor in fat body mosquitoes. A member SLC7 family transporters, it paramount for detection elevated levels mosquito hemolymph after a blood meal and subsequent changes gene expression body.We performed re-annotation Aedes aegypti transporters (CATs) selected C-terminal tail CAT1 to perform yeast two-hybrid screen identify putative interactors this protein. One interesting interacting we identified was general...
Background Hypertension is a major public health challenge in the world. Developing countries share burden of it. Unlike thought before, hypertension increasing among poor, young and women. Methods It was cross sectional study carried out The Screening Awareness Program conducted shopping malls at heart Kathmandu on occasion World Day 2012 by Shahid Gangalal National Heart Center, Kathmandu. blood pressure measured according to Organization’s guideline registered nurses. There were total 486...
After taking a blood meal, the fat body of adult female yellow fever mosquito, Aedes aegypti, switches from previtellogenic state arrest to an active synthesizing large quantities yolk protein precursors (YPPs) that are crucial for egg development. The synthesis YPPs is regulated at both transcriptional and translational levels. Previously, we identified cytoplasmic general control nonderepressible 1 (GCN1) as part regulatory pathway YPP synthesis. In current study, used C-terminal end GCN1...
Background: The emergence and circulation of dengue infection have become one the major public health concerns in world with its high prevalence sub-tropical tropical countries. Hundreds Dengue cases been reported annually shift serotypes every year has raised concern Nepal. detection virus infections different areas a great role for clinical management patients, surveillance, trial assessments days to come. Methods materials: Clinically suspected (n = 240) were subjected sero analysis...
Human Immunodeficiency Virus is a lentivirus that causes human immunodeficiency virus infection and over time, acquired syndrome. Cluster of Differentiation 4+ T cell count people living with this play vital role to determine progression necessary treatment changes. This study was conducted find out the prevalence low Cell Count in People Living virus/ syndrome.A descriptive cross-sectional between June August 2018 Hepatitis Reference Unit National Public Health Laboratory, Ministry...