A5031908226- Antibiotic Resistance in Bacteria
- Research on Leishmaniasis Studies
- Antibiotic Use and Resistance
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Viral Infections and Vectors
- Pharmaceutical and Antibiotic Environmental Impacts
- Global Maternal and Child Health
- Tuberculosis Research and Epidemiology
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Child Nutrition and Water Access
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Thyroid Disorders and Treatments
Tribhuvan University
2016-2025
World Health Organization
2011-2024
Special Programme for Research and Training in Tropical Diseases
2023-2024
Instituut voor Tropische Geneeskunde
2024
Universidad Nacional de Córdoba
2024
B.P. Koirala Institute of Health Sciences
2024
Beltsville Agricultural Research Center
2024
Agricultural Research Service
2024
Kathmandu University
2024
Dhulikhel Hospital
2024
Escherichia coli is the most predominant causative agent of urinary tract infection (UTI). Recently, increase in drug resistance among uropathogenic bacteria has caused great problem treatment UTI. The main objective this research to determine correlation between biofilm formation and toward different commonly used antibiotics along with extended spectrum beta lactamase production coli.The urine samples collected from patients suspected infections (visiting Shree Birendra Hospital, Chhauni,...
Improper dietary intake pattern in women of reproductive age Nepal has resulted the deficiency essential nutrients. Adequate nutritional status and proper improves maternal child health. The objective this study was to assess among associated factors.Data collection at households health check-up camps were conducted selected Village Development Committees nine districts three ecological regions (Mountain, Hill Terai) from September 2011 August 2012. Women (15 49 years) subjects. At household...
Abstract Background Dengue is one of the newest emerging diseases in Nepal with increasing burden and geographic spread over years. The main objective this study was to explore epidemiological patterns dengue since its first outbreak (2006) 2019 Nepal. Methods This a retrospective analysis that covers last 14 years (2006–2019) reported cases from Epidemiology Diseases Control Division (EDCD), Ministry Health Population, Government . Reported were plotted time maps case incidence generated...
Treatment and prevention of wound infection continues to be a challenging issue in clinical settings Nepal especially the context globally growing problem antimicrobial resistance. Study on opportunistic pathogens sensitivity commonly prescribed local agents are cardinal reduce disease burden infections. The aim this study was determine prevalence susceptibility pattern methicillin resistant Staphylococcus aureus (MRSA) extended spectrum β-lactamase (ESBL) producing bacteria from infections...
Xpert MTB/RIF assay is regarded as a great achievement of modern medicine for the rapid diagnosis multidrug-resistant tuberculosis (MDR-TB). The main purpose this study was to determine performance compared conventional drug susceptibility testing (DST) method MDR-TB. A comparative cross sectional carried out at German-Nepal Tuberculosis Project, Kathmandu, Nepal, from April 2014 September 2014. total 88 culture positive clinical samples (83 pulmonary and 5 extra-pulmonary) received during...
Introduction: Resistance to carbapenem in Gram-negative bacteria is attributable their ability produce carbapenemase enzymes. The main objective of this study was detect the presence blaOXA-48 genes carbapenem-resistant uropathogenic Escherichia coli and Klebsiella pneumoniae isolated from urine samples patients attending Alka Hospital, Jawalakhel, Lalitpur, Nepal. Methods: A total 1013 mid-stream were collected with suspected urinary tract infection (UTI) between April September 2018....
Emergence and spread of antimicrobial resistance (AMR) is a global threat significantly affects the treatment options for common infectious diseases. Inappropriate use antibiotics, particularly third-generation cephalosporins, has contributed to development AMR. This study aims determine prevalence extended-spectrum β-lactamase (ESBL) production in Escherichia coli Klebsiella species isolated from various clinical samples.This cross-sectional was conducted at International Friendship...
Cholera, an infectious disease caused by Vibrio cholerae, is a major public health problem and particularly burden in developing countries including Nepal. Although the recent worldwide outbreaks of cholera have been due to V. cholerae El Tor, classical biotypes are still predominant Serogroup O1 biotype was primary cause outbreak Kathmandu 2012. Thus, this study designed know serotypes strains causing with reference drug resistant patterns. Moreover, we also report toxigenic from both...
The expansion of dengue vectors from lowland plains to the upland hilly regions Nepal suggests likelihood increased risk dengue. Our objective was assess effects meteorological variables on vector indices and populations in two different ecological Nepal. An entomological survey conducted Kathmandu Lalitpur (upland) Chitwan (lowland) three seasons July 2015 May 2016. effect (house index, container index Breteau index) Aedes spp. population abundance analyzed. A gamma regression used fit...
Abstract Background Plasmid-mediated resistance to the last-resort drugs: carbapenems and colistin is an emerging public health threat. The studies on prevalence co-expression of resistant genes among livestock human pathogens are rare in Nepal. This first study Nepal exploring co-existence gene, mcr -1 along with carbapenemase OXA -48 Escherichia coli isolated from poultry clinical specimens. Methods A total 240 rectal swabs chickens five different farms Kathmandu valley 705 mid-stream...
Abstract Nepal suffers from high burden of antimicrobial resistance (AMR) due to inappropriate use antibiotics. The main objective this study was explore knowledge, attitude and practices antibiotics uses among patients, healthcare workers, laboratories, drug sellers farmers in eight districts Nepal. A cross-sectional survey conducted between April July 2017. total 516 individuals participated a face-to-face interview that included clinicians, private dispensers, public health...
While direct-acting antivirals (DAAs) are available for the treatment of chronic Hepatitis C virus (HCV) patients in Nepal, knowledge circulating genotypes/subtypes and drug target gene mutations HCV is currently unavailable. Here, we describe identify antiviral at a tertiary care hospital using genome data. A cross-sectional study was conducted from December 2019 to February 2024, where PCR followed by whole sequencing performed mutations. Among all who tested positive anti-HCV, 70.6%...
Abstract Background: The emergence of antibiotic resistance, particularly plasmid-mediated colistin poses a critical threat to global public health, given colistin’s role as last-resort for treating multidrug-resistant (MDR) bacterial infections. Despite its significance, data on resistance and the prevalence mobile ( mcr ) genes in Nepal are scarce. This study aims investigate occurrence mobilized mcr-1 mcr-2 MDR Escherichia coli isolates from clinical specimens, highlighting burden...
Although, when applied under controlled conditions in India and Nepal, indoor residual spraying (IRS) has been found to reduce sandfly densities significantly, it is not known if IRS will be as effective generally these countries, via the national programmes for elimination of visceral leishmaniasis. The potential benefits limitations control sandflies were therefore evaluated districts Vaishali (in Indian state Bihar), Sarlahi Nepal) Sunsari (also Nepal). use technical guidelines, levels...
The prevalence of antimicrobial resistance (AMR) among Gram-negative bacteria is alarmingly high. Reintroduction colistin as last resort treatment in the infections caused by drug-resistant has led to emergence and spread resistance. This study was designed determine drug-resistance beta-lactamase-producing strains Escherichia coli Klebsiella pneumoniae, isolated from clinical specimens received at a tertiary care centre Kathmandu, Nepal during period March August, 2019.A total 3216...
We sequenced Leishmania donovani genomes in blood samples collected emerging foci of visceral leishmaniasis western Nepal. detected lineages very different from the preelimination main parasite population, including a new lineage and rare one previously reported eastern Our findings underscore need for genomic surveillance.
Alcohol chemically known as ethanol, causes several health, economic and social consequences across the world. Literatures suggest potential harm of alcohol drinking by pregnant women especially to fetus mother. Despite a number significant public health problems related consumption, this area has been ignored in Nepal information at national level is limited. Thus study aimed finding prevalence consumption among married reproductive age.A nationally representative household survey was...
As malaria cases have declined throughout Nepal, imported comprise an increasing share of the remaining caseload, yet how to effectively target mobile and migrant populations (MMPs) at greatest risk is not well understood. This formative research aimed confirm link between indigenous cases, characterize high-risk MMPs, identify opportunities adapt surveillance intervention strategies them. The study used a mixed-methods approach in three districts far mid-western including (i) retrospective...
Background: Plasmid-mediated resistance to the colistin in poultry is considered as an emerging problem worldwide. While constitutes major industry Nepal, there a paucity of evidence on Escherichia coli isolates causing natural infections poultry. This study aimed explore prevalence plasmid-mediated gene, mcr-1 E. isolated from liver samples dead suspected infections. Methods: A total two hundred and seventy (227 broilers 43 layers) colibacillosis were collected post-mortem Central...