A5048216274- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- COVID-19 and Mental Health
- Pediatric health and respiratory diseases
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- Cardiovascular and exercise physiology
- Mobile Health and mHealth Applications
- Cardiovascular Function and Risk Factors
- Phonocardiography and Auscultation Techniques
Royal Free London NHS Foundation Trust
2017-2025
University College London
2017-2025
Roland Hill (United Kingdom)
2024
The Royal Free Hospital
2018-2023
London Chest Hospital
2006-2021
King's College London
2012-2020
Guy's and St Thomas' NHS Foundation Trust
2011-2020
St Thomas' Hospital
2011-2020
Kings Health Partners
2020
ENT and Allergy
2016
Large numbers of people are being discharged from hospital following COVID-19 without assessment recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. those with elevated biomarkers, 30.1% 9.5% persistently d-dimer C reactive protein, respectively. 38% chest radiographs remained abnormal 9% deteriorating. Systematic follow-up after hospitalisation identifies...
### Monitoring, precautions and complications ### Hypoxaemia ### Cardiac arrhythmias ### Bleeding complications
<b>Adults discharged from hospital with COVID-19 may experience "Long COVID", where mental health symptoms are significant and linked to physical such as breathlessness. Clinicians should use brief screening questionnaires support their recovery.</b>https://bit.ly/3d22SJM
| Diagnosis of mediastinal/hilar lymph nodes and peribronchial masses || Conventional transbronchial fine needle aspiration (TBNA) B √ Endobronchial ultrasound-guided (EBUS-TBNA) D Therapeutic procedures for malignant disease Malignant airway obstruction 1. debulking tumours 2. electrocautery or diathermy
ln this report, we describe the ability of ellagic acid (EA), a phenolic compound present in number fruits and nuts, to inhibit N-nitrosobenzylmethylamnine (NEMA) twnorigenesis rat esophagus. When administered semi-purified diet at concentrations 0.4 4 glkg, EA produced significant (21–55%) decrease average NBMA-induced esophageal tumors after 20 27 weeks bioassay. FA exhibited inhibitory effects toward preneoplastic lesions as well neoplastic lesions. Tumors were not observed...
Abstract Background Coronavirus disease 2019 (COVID-19) is an evolving infectious that dramatically spread all over the world in early part of 2020. No studies have yet summarised potential severity and mortality risks caused by COVID-19 patients with chronic obstructive pulmonary (COPD), we update information smokers. Methods We systematically searched electronic databases from inception to March 24, Data were extracted two independent authors accordance Preferred Reporting Items for...
Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular diseases (CVD) commonly co-exist. Outcomes of people living with both conditions are poor in terms symptom burden, receiving evidence-based treatment mortality. Increased understanding the underlying mechanisms may help to identify treatments relieve this disease burden. This narrative review covers overlap COPD CVD a focus on clinical presentation, mechanisms, interventions. Literature up December 2023 cited.
This new guideline covers the rapidly advancing field of interventional bronchoscopy using flexible bronchoscopy. It includes use more complex diagnostic procedures such as endobronchial ultrasound, interventions for relief central airway obstruction due to malignancy and recent development therapies chronic obstructive pulmonary disease asthma. The aims help all those who undertake understand about this important area. also inform respiratory physicians other specialists dealing with lung...
<h3>Rationale</h3> Hospitalised patients with acute exacerbation of COPD may deteriorate despite treatment, early readmission being common. <h3>Objectives</h3> To investigate whether neural respiratory drive, measured using second intercostal space parasternal muscle electromyography (EMG<sub>para</sub>), would identify worsening dyspnoea and physician-defined inpatient clinical deterioration, predict readmission. <h3>Methods</h3> Patients admitted to a single-site university hospital were...
<h3>Introduction</h3> Patient-ventilator asynchrony (PVA) can adversely affect the successful initiation of non-invasive home mechanical ventilation (HMV). The aim this observational study was to quantify prevalence PVA during HMV and determine relationship between nocturnal gas exchange. <h3>Method</h3> Type frequency were measured by surface parasternal intercostal muscle electromyography, thoracoabdominal plethysmography mask pressure HMV. Severe defined, as previously, affecting ≥10%...
Ventilation parameter data from patients receiving home mechanical ventilation can be collected via secure cards and modem technology. This then reviewed by clinicians ventilator prescriptions adjusted. Typically available measures include tidal volume (VT), leak, respiratory rate, minute ventilation, patient triggered breaths, achieved pressures compliance. study aimed to assess the potential impact of downloads on management requiring non-invasive (NIV).A longitudinal within-group design...
Readmission following COPD exacerbation is a common and challenging clinical problem. New approaches to predicting readmissions are required help mitigate risk develop novel interventions.We conducted prospective cohort study in 82 patients admitted due an of COPD. Lung function measures [spirometry, forced oscillation technique (FOT) indices peak inspiratory flow rate (PIFR)], inflammatory biomarkers patient-reported outcomes including previous history, breathlessness, quality life frailty...
Current guidelines recommend that patients with obesity hypoventilation syndrome (OHS) are electively admitted for inpatient initiation of home non-invasive ventilation (NIV). We hypothesised outpatient NIV setup would be more cost-effective.Patients stable OHS referred to six participating European centres were recruited an open-labelled clinical trial. Patients randomised via web-based system using stratification setup, standard fixed level and titrated during attended overnight...
Background Ongoing exercise intolerance of unclear cause following COVID‐19 infection is well recognized but poorly understood. We investigated capacity in patients previously hospitalized with and without self‐reported using magnetic resonance–augmented cardiopulmonary testing. Methods Results Sixty subjects were enrolled this single‐center prospective observational case‐control study, split into 3 equally sized groups: 2 groups age‐, sex‐, comorbidity‐matched clearly identifiable postviral...
Abstract Background Long-COVID research to date focuses on outcomes in non-hospitalised vs. hospitalised survivors. However Emergency Department attendees (post-ED) presenting with acute COVID-19 may experience less supported recovery compared people admitted and discharged from hospital (post-hospitalised group, PH). Objective We evaluated predictors of specialty care referrals (SCR) those ongoing symptomatic Long-COVID, comparing post-ED PH adults. Methods This prospective observational...
Ellagic acid (EA), a plant phenol found in various fruits and nuts, was examined for its ability to inhibit aflatoxin B 1 (AFB ) mutagenesis strain TA 100 of Salmonella typhimurium . In the presence rat liver S-9 microsomal preparation, EA (1.5 μ g/plate) inhibited number mutations induced by AFB, (0.5 50%. at dose 1000 g/plate mutation frequency >90%. also tested DNA binding adduct formation AFB cultured explants trachea human tracheobronchus. Explants were incubated medium containing...
Background Respiratory management of obesity hypoventilation syndrome (OHS) focusses on the control sleep-disordered breathing rather than treatment obesity. Currently, there are no data from randomised trials weight loss targeted rehabilitation programmes for patients with OHS. Intervention A 3-month multimodal hybrid inpatient–outpatient motivation, exercise and nutrition programme, in addition to non invasive ventilation (NIV), would result greater per cent compared standard care. Methods...