A5080228269- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Child and Adolescent Psychosocial and Emotional Development
- Acute Ischemic Stroke Management
- Tuberculosis Research and Epidemiology
- Schizophrenia research and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mental Health and Psychiatry
- Cerebrovascular and Carotid Artery Diseases
- Organ Transplantation Techniques and Outcomes
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Health disparities and outcomes
- Stroke Rehabilitation and Recovery
- Liver Disease and Transplantation
- Maternal Mental Health During Pregnancy and Postpartum
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
- Organ Donation and Transplantation
- Lipoproteins and Cardiovascular Health
King's College London
2010-2023
IQVIA (United Kingdom)
2022
London School of Hygiene & Tropical Medicine
2016-2021
Institute of Population and Public Health
2011-2019
Primary Health Care
2010-2017
University of Manchester
2012-2015
Kings Health Partners
2010-2011
Psychiatry Research Trust
2010
Peninsula College of Medicine and Dentistry
2009
University of Sheffield
2009
Background. Although stigma in relation to mental health has been defined as including components of knowledge, attitudes and behaviour, no psychometrically tested instrument assess behavioural discrimination at the population level developed. This paper presents details development psychometric properties Reported Intended Behaviour Scale (RIBS), an based on Star Social Distance Scale, reported (past current) intended (future) among general public against people with problems. Methods....
With recent advances in secondary prevention management, stroke recurrence rates may have changed substantially. We aim to estimate risks and trends of over the past 2 decades a population-based cohort patients with stroke.Patients first-ever between 1995 2018 South London, United Kingdom (n=6052) were collected analyzed. Rates recurrent 95% CIs stratified by 5-year period index etiologic TOAST (Trial ORG 10172 Acute Stroke Treatment) subtype. Cumulative incidences estimated multivariate Cox...
BackgroundCurrent diagnostics for HIV-associated tuberculosis are suboptimal, with missed diagnoses contributing to high hospital mortality and approximately 374 000 annual HIV-positive deaths globally. Urine-based assays have a good diagnostic yield; therefore, we aimed assess whether urine-based screening in inpatients improved outcomes.MethodsWe did pragmatic, multicentre, double-blind, randomised controlled trial two hospitals Malawi South Africa. We included medical aged 18 years or...
Individuals often choose not to seek help for or disclose their mental illness. This study examined whether having more positive attitudes and knowledge about illness could predict intentions from a general practitioner friends family members.A Department of Health survey in England assessed illness, toward people with level contact someone among 1,751 adults representative the population.With controls social grade race-ethnicity, were predicted by better tolerance support community care...
Suicide is a leading cause of perinatal maternal deaths in industrialised countries but there has been little research to investigate prevalence or correlates postpartum suicidality. The Edinburgh Postnatal Depression Scale widely used primary and maternity services screen for depressive disorders, includes question on suicidal ideation (question 10). We aimed the prevalence, persistence thoughts women context randomised controlled trial treatments postnatal depression. Women care were sent...
Direct social contact interventions are known to reduce mental health stigma. Filmed may be equally effective and have practical cost advantages.To compare the effectiveness of a DVD, live intervention lecture control, in reducing stigma, testing hypotheses that: (a) DVD will effective; (b) with (DVD/live) more than lecture. Cost-effectiveness, process acceptability also assessed.Student nurses were randomised to: watch service users/informal carers talking about their experiences, similar...
Background Research suggests that levels of discrimination against people using mental health services are high; however, reports these people's experiences rare. Aims To determine whether the Time to Change (TTC) programme target 5% reduction in has been achieved. Method Separate samples were interviewed annually from 2008 2011 Discrimination and Stigma Scale record instances discrimination. Results Ninety-one per cent participants reported one or more compared with 88% (z=-1.9, P =0.05)....
Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of Sahel where malaria highly seasonal. The recommendation SMC currently limited to under five years age, but, many seasonal transmission, burden older may justify extending this age limit. This study was done determine effectiveness Senegalese up ten age.SMC introduced into three districts over central...
Objective: To evaluate the impact on general public of England's Time to Change program reduce mental health-related stigma and discrimination using newly developed measures knowledge intended behaviour regarding people with health problems, an established attitudes scale, investigate whether social desirability affects responses new test this varies according data collection method. Method: The Mental Health Knowledge Schedule (MAKS) Reported Intended Behaviour Scale (RIBS) were...
To investigate the long-term impact of antenatal domestic violence on maternal psychiatric morbidity and child behaviour.Cohort study.Avon, UK.A birth cohort 13,617 children mother dyads were followed to 42 months age.Experiences depressive symptoms gathered at 18 weeks gestation up 33 after birth, together with maternal, paternal characteristics.Child behavioural problems assessed using Revised Rutter Questionnaire.Logistic regression use multiple imputation employing chained equations for...
Background Service users express dissatisfaction with inpatient care and their concerns revolve around staff interactions, involvement in treatment decisions, the availability of activities safety. Traditionally, satisfaction acute has been assessed using measures designed by clinicians or academics.Aims To develop a patient-reported outcome measure perceptions care. An innovative participatory methodology was used to involve services throughout research process.Method A total 397...
Stigma and discrimination associated with mental health problems is an important public issue, interventions aimed at reducing exposure to stigma can improve the lives of people problems. Social contact has long been considered be one most effective strategies for improving inter-group relations. For this study, we assess impact a population level social intervention among without This study investigated whether presence specific facilitating factors (equal status, common goals, cooperation...
Objective: This study evaluated the progress at one year of England's Time to Change (TTC) program, launched in 2009, toward meeting its target reduce mental health-related stigma and discrimination by 5%. Methods: TTC comprises three national components: antistigma marketing campaign activities, mass physical exercise events (Time Get Moving) facilitate social contact between people with without health problems, an online resource on employment Challenge). Part evaluation consists annual...
This study assesses five year outcomes of patients with cognitive deficits within the first three months after stroke. Population-based data from South London Stroke Register between 1995 and 2018 were studied. Cognitive function was assessed using Abbreviated-Mental-Test or Mini-Mental-State-Examination. Multivariable Poisson regression models robust standard errors constructed, to evaluate relative risks (RRs) associations post-stroke deterioration in during on dependency, mortality,...
Abstract Background Trafficking in women is a widespread human rights violation commonly associated with poor mental health. Yet, to date, no studies have used psychiatric diagnostic assessment identify common forms of distress among survivors returning their home country. Methods A longitudinal study was conducted aged 18 and over who returned Moldova between December 2007 2008 registered by the International Organisation for Migration as survivor trafficking. Psychiatric diagnoses at mean...
Background Compulsory admission to psychiatric hospitals may be distressing, disruptive patients and families, associated with considerable cost the health service. Improved patient experience reductions could realised by providing cost-effective crisis planning services. Methods Economic evaluation within a multi-centre randomised controlled trial comparing Joint Crisis Plans (JCP) plus treatment as usual (TAU) TAU alone for aged over 16, at least one hospital in previous two years on...
Current tuberculosis diagnostics lack sensitivity, and are expensive. Highly accurate, rapid cheaper diagnostic tests required for point of care use in low resource settings with high HIV prevalence.To investigate the sensitivity specificity, cost loop-mediated isothermal amplification (LAMP) assay diagnosis adults chronic cough compared to Xpert® MTB/RIF, fluorescence smear microscopy.Between October 2013 March 2014, consecutive at a primary clinic were screened cough, offered testing...
Current guidelines recommend that patients with obesity hypoventilation syndrome (OHS) are electively admitted for inpatient initiation of home non-invasive ventilation (NIV). We hypothesised outpatient NIV setup would be more cost-effective.Patients stable OHS referred to six participating European centres were recruited an open-labelled clinical trial. Patients randomised via web-based system using stratification setup, standard fixed level and titrated during attended overnight...
Internalised stigma in young people meeting criteria for at-risk mental states (ARMS) has been highlighted as an important issue, and it suggested that provision of cognitive therapy may increase such stigma.To investigate the effects on internalised using a secondary analysis data from EDIE-2 trial.Participants ARMS were recruited part multisite randomised controlled trial prevention amelioration psychosis. Participants assessed at baseline 6, 12, 18 24 months measures psychotic...
<h3>Background</h3> Contact tracing is a key element in England9s 2015 collaborative TB strategy, although proposed indicators of successful contact remain undescribed. <h3>Methods</h3> We conducted descriptive and multivariable analyses cases London between 1 July 2012 31 December using cohort review data from London9s Register, identifying characteristics associated with improved yield. <h3>Results</h3> Of the pulmonary notified, 60% (2716/4561) had sufficient information for inclusion....
The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion injury solid organ transplantation. Mirococept is potent membrane-localizing inhibitor that can be administered ex vivo to donor kidney prior To evaluate efficacy reducing delayed graft function (DGF) deceased renal transplantation, we undertook mirococept (APT070) for preventing ischaemia-reperfusion allograft (EMPIRIKAL) trial (ISRCTN49958194). A dose range 5-25 mg would tested, starting with 10 cohort...