A5022156119- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Microbial Natural Products and Biosynthesis
- Microbial Community Ecology and Physiology
- Renal and related cancers
- MicroRNA in disease regulation
- DNA and Nucleic Acid Chemistry
- Coral and Marine Ecosystems Studies
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Zebrafish Biomedical Research Applications
- Lung Cancer Treatments and Mutations
- Phytochemical compounds biological activities
- Plant-Microbe Interactions and Immunity
- Advanced biosensing and bioanalysis techniques
- Fungal Biology and Applications
- Echinoderm biology and ecology
- Plant and animal studies
- Mesenchymal stem cell research
Candiolo Cancer Institute
2023-2025
University of Palermo
2020-2023
The use of chemical fertilizers and pesticides has caused harmful impacts on the environment with increase in economic burden. Biofertilizers are biological products containing living microorganisms capable improving plant growth through eco-friendly mechanisms. In this work, three actinobacterial strains Streptomyces violaceoruber, coelicolor, Kocuria rhizophila were characterized for multiple promoting (PGP) traits such as indole acetic acid production, phosphate solubilization,...
Abstract In the present work, culture-based and culture-independent investigations were performed to determine microbiota structure of coelomic fluid Mediterranean sea urchin Paracentrotus lividus individuals collected from two distinct geographical sites neighboring a high-density population bay nature reserve, respectively. Next Generation Sequencing analysis 16S rRNA gene (rDNA) showed that members Proteobacteria , Bacteroidetes Fusobacteria phyla, which have been previously reported be...
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge for early diagnosis due to the lack of sensitive and specific biomarkers. This encouraged us explore diagnostic value cancer-derived small extracellular vesicles (sEVs) as detection We previously showed that recombinant malaria protein VAR2CSA (rVAR2) selectively binds oncofetal chondroitin sulfate (ofCS) on surfaces cancer cells, which might be useful identifying sEVs. Indeed, flow cytometry revealed strong ofCS...
Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving "liquid biopsy" enables the generation of in vitro 3D models and highly aggressive vivo for functional molecular studies advanced PDAC. Within retrieved CTC pool (median 65 CTCs/5 mL), identify subset content 8.9%) CXCR4
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness resilience against chemotherapy existence cancer stem cells (CSCs). The important task discovering upstream regulators stemness that are amenable for targeting in PDAC essential advancement more potent therapeutic approaches. In this study, we sought to elucidate function nuclear receptor subfamily 5, group A, member 2 (NR5A2) context...
Conditioned media harvested from stem cell culturing have the potential to be innovative therapeutic tools against various diseases, due their high content of growth, trophic and protective factors. The evaluation in vivo effects biosafety these products is essential, zebrafish provides an ideal platform for high-throughput toxicological analysis, concurrently allowing minimization use mammalian models without losing reliability. In this study, we assessed biological elicited by exposure...