A5067019874- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Phytoestrogen effects and research
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Trace Elements in Health
- Anesthesia and Neurotoxicity Research
- Nutrition and Health in Aging
- Protein Tyrosine Phosphatases
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Intellectual Capital and Performance Analysis
- Morinda citrifolia extract uses
- Innovation Diffusion and Forecasting
- Optical Imaging and Spectroscopy Techniques
- Molecular Sensors and Ion Detection
- Advanced MRI Techniques and Applications
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Electron Spin Resonance Studies
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Technology Adoption and User Behaviour
North China University of Science and Technology
2011-2023
Max Delbrück Center
2021
Hospital of Hebei Province
2020
Tianjin Medical University
2015-2017
TED University
2011-2013
Jinan University
2011
Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 involved the protection zinc ion on cardiac I/R Mouse hearts were subjected to 30 minutes regional ischemia followed by 2 hours reperfusion (ischemia/reoxygenation (I/R)). Infarct size apoptosis assessed. HL-1 cells 24 hypoxia 6 reoxygenation (hypoxia/reoxygenation (H/R)). was given 5 min before for min. SENP2 overexpression plasmid...
Common genetic variants (single-nucleotide polymorphisms [SNPs]) in microRNA genes may alter their maturation or expression, resulting varied functional consequences. Several studies have evaluated the association between SNP rs11614913 and cancer risk diverse populations a range of cancers, with contradictory outcomes. In this study, we examined 114 paired samples (tumor normal tissues) from breast patients to study genotype distribution somatic mutation MIR 196A2 (rs11614913 C-T)....
Primary hepatocellular carcinoma (PHC) is a major health problem worldwide and one of the 10 most commonly diagnosed cancers in China. Heat shock protein 27 (HSP27) were found to be overexpressed wide range malignancies including PHC, however, post-translational modification HSP27 still needs exploration PHC. Recently, SUMOylation, an important associating with development many kinds has been intensively studied. In current study, mRNA level archived tumor samples representing various...
Mitophagy is an essential factor in mitochondrial quality control and myocardial ischaemia/reperfusion (I/R) injury protection. Because adenosine A2B receptor (A2BR) activation exerts a major role reducing I/R injury, the effects of A2BR on cardiac mitophagy under reperfusion conditions were investigated.110 adult Wistar rats (7-10 w), weighing 250-350 grams, cultured specific-pathogen-free (SPF) before experiments. All hearts removed reperfused by Langendorff device. Six with coronary flow...
ABSTRACT Objective : Although several methods have been used to detect the intracellular reactive oxygen species (ROS) generation, it is still difficult determine where ROS generate from. This study aimed demonstrate whether from mitochondria during oxidative stress induced damage in cardiac H9c2 cells by laser scanning confocal microscopy (LSCM). Methods Cardiac were exposed H 2 O (1200μM) induce mitochondrial oxidant damage. Mitochondrial membrane potential (ΔΨm) was measured staining with...
To explore the role of mitochondrial permeability transition pore (mPTP) in mediating protective effect gastrodin against oxidative stress damage H9c2 cardiac myocytes.H9c2 myocytes were treated with H2O2, gastrodin, gastrodin+H2O2, cyclosporin A (CsA), or CsA+gas+H2O2 group. MTT assay was used to detect survival ratio cells, and flow cytometry Annexin V-FITC/PI double staining analyze early apoptosis rate after treatments. The concentration ATP level reactive oxygen species (ROS) cells...
To investigate the effect of prolonged sevoflurane (SEV) exposure on differentiation potential and hypoxia tolerance neural stem cells (NSCs).NSCs were extracted from 15-day fetal mice. After sub-culture, SEV treatment was performed. Cell cycle detected by flow cytometry. Western blot immunofluorescence assay used to detect expression spatial distribution Nestin, NSE, GFAP, Oct4, SOX2; CCK-8 cell viability. growth morphology observed under a microscope. TUNEL apoptosis; concentration...
<h3>Objectives Aims</h3> We previously documented that morphine upregulates Akt activity by inactivating protein Ser/Thr phosphatases via reactive oxygen species (ROS) may contribute to the protective effect of on ischaemia/reperfusion injury, but molecular mechanism underlying morphine-induced ROS production remains be defined. Since receptor tyrosine kinases (RTKs) cardiac protection induced activation opioid, bradykinin, or muscarinic receptors and could increase intracellular production,...
Effects of technological innovation on performance are significantly important to firm's competitive advantages. This paper aims find the key points when studying effects performance, and build a conceptual model. The results show that R&D marketing capabilities critical. In model, not only capabilities, but also integration two should be included. will contribute further empirical research in this field.
<h3>Objectives</h3> Glycogen synthesis kinase-3β (GSK-3<i>β</i>) has been widely proved to be linked the inhibition of mPTP opening. This study aimed determine whether puerarin prevents oxidative stress-induced mitochondrial damage via inhibiting GSK-3β activity. <h3>Methods</h3> Cardiac H9c2 cells were exposed H<sub>2</sub>O<sub>2</sub> for 20 min induce damage. Mitochondrial membrane potential (ΔΨm) was measured by staining with tetramethylrhodamine ethyl ester (TMRE). V-akt-murinet hymoma...
<h3>Objectives</h3> This study aimed to test the protection of puerarin in oxidative stress-induced mitochondrial injury rat cardiac H9c2 cells. <h3>Methods</h3> Rat heart tissue-derived cells were used. First, we if could modulate mPTP opening. To detect opening, loaded with TMRE and imaged confocal microscopy. After treatments at different concentrations, exposed 650 µM H<sub>2</sub>O<sub>2</sub> induce tested by MTT assay cell activity. define signalling mechanism responsible for...