A5052483490- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- vaccines and immunoinformatics approaches
- Glycosylation and Glycoproteins Research
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Xenotransplantation and immune response
- Cervical Cancer and HPV Research
- Signaling Pathways in Disease
- Vector-Borne Animal Diseases
- Rheumatoid Arthritis Research and Therapies
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
Chonnam National University
2023-2024
Kwangwoon University
2023
Academy of Military Medical Sciences
2005-2020
Beijing VDJBio (China)
2020
Tianjin Hospital
2020
First Hospital of Jilin University
2019
Jilin University
2019
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2009-2017
Seoul National University of Science and Technology
2017
Institute of Physiology and Basic Medicine
2015
To identify the function of HAb18G/CD147 in invasion host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed protein-protein interaction among HAb18G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins coimmunoprecipitation surface plasmon resonance analysis. Although none was found to be directly bound nucleocapsid (N) protein CyPA, which interacted with HAb18G/CD147. Further research showed that a transmembrane molecule, highly expressed on 293 CyPA...
This study examines the structure and effects of intercultural interactions between international tourists local residents. It develops variables affecting relationships, process outcomes interactions, any resultant attitude changes. An integrated model was derived from shared themes, meanings, patterns that shaped participants’ tourism experiences. The is composed structures interactions. These through reflective, comparative, comprehensive experiences, impact tourists’ toward people their...
Abstract The prognosis of gastric cancer remains poor due to clinical drug resistance. Novel drugs are urgently needed. Shikonin (SHK), a natural naphthoquinone, has been reported trigger cell death and overcome resistance in anti-tumour therapy. In this study, we investigated the effectiveness molecular mechanisms SHK treatment with cancer. vitro , suppresses proliferation triggers cells but leads minor damage epithelial cells. induces generation intracellular reactive oxygen species (ROS),...
As a regulated form of programmed cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage domain-like protein (MLKL), which combine to necroptotic signaling pathway mediate induced by various stimuli, tumor necrosis factor (TNF). Although chemical inhibition RIPK1 blocks TNF-induced necroptosis, genetic elimination does not suppress but facilitate triggered TNF. Moreover, been reported...
ABSTRACT This study investigates the process involved in developing a medical tourism industry South Korea as case country, one of fastest growing countries with strong potential industry. It analyzed 252 articles on posted websites Korean Tourism Organization and International Medical Association. Both sources are highly representative portal for country. The article aims to enhance understanding new growth while identifying its key developmental characteristics makes valuable suggestions...
Botulinum neurotoxin (BoNT) is a highly lethal toxin produced by the anaerobic bacterium Clostridium botulinum, which leads to nerve paralysis following poisoning. At present, there no specific drug officially approved. Antibodies, particularly single-domain antibodies, represent safe and effective candidates for drugs against BoNT. In this study, receptor-binding domain of botulinum (BoNT/AHCC) was utilized immunize Bactrian camels, resulting in generation nanobody phage library. From...
Necroptosis is a regulated form of necrotic cell death that mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage domain-like protein (MLKL), which mediates necroptotic signal transduction induced tumor necrosis factor (TNF). Although many target proteins for necroptosis have been identified, no report had indicated FK506-binding 12 (FKBP12, also known as FKBP1A), an endogenous regulates folding conformation alteration, involved in mediating...
A pattern gel has been fabricated using sodium hyaluronate (HA) and 1,4-butanediol diglycidyl ether (BDDGE) through the micro-molding technique. The cellular behavior of osteoblast cells (MC3T3) in presence absence dimethyloxalylglycine (DMOG) borate (NaB) (HA-BDDGE) evaluated for its potential application bone regeneration. Fourier transform infrared spectroscopy (FTIR), 13C-nuclear magnetic resonance (13C NMR), thermogravimetric analysis (TGA) results implied crosslinking reaction between...
Abstract To date, molecular targets chosen for Ab activation to generate antitumor effector cells have been confined on T cells, such as TCR/CD3, CD28, CD137 (4-1BB), CD134 (OX40), and inducible costimulator. In this report we investigated the immune function of murine tumor-draining lymph node (TDLN) after simultaneous targeting CD3 CD40 APCs. Anti-CD3 plus anti-CD40-activated TDLN secreted significantly higher amounts IFN-γ, but less IL-10, compared with anti-CD3-activated cells. adoptive...
Abstract As a nitric oxide (NO) donor prodrug, JS‐K inhibits cancer cell proliferation, induces the differentiation of human leukaemia cells, and triggers apoptotic death in various models. However, anti‐cancer effect gastric has not been reported. In this study, we found that inhibited proliferation cells vitro vivo triggered mitochondrial apoptosis. Moreover, induced significant accumulation reactive oxygen species (ROS), clearance ROS by antioxidant reagents reversed JS‐K‐induced toxicity...
DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added enhance immunogenicity. In this study, we generated a tumor vaccine using plasmid encoding NMM (NY-ESO-1/MAGE-A3/MUC1) target antigens immune-associated molecules. The products of the were analyzed in 293 T cells by western blotting, flow cytometry, meso-scale discovery electrochemiluminescence. To assess immunogenicity...
T lymphocytes are key inflammatory cells contributing significantly to the pathogenesis of Rheumatoid arthritis (RA). Biological treatments targeting may provide an efficient approach for treatment RA. CTLA4–FasL, a fusion product extracellular domains CTLA4 and FasL, integrating two inhibitory elements against into one molecule, might be desirable derivative engineered soluble FasL or have therapeutic potential in The aim this study was investigate whether simultaneous induction...
Long interspersed nucleotide element (LINE-1; L1) as an autonomous retrotransposon is localized usually in AT-rich, low-recombined, and gene-poor regions of genome. It transiently activated embryonic development continuously all tumor cells tested so far. Full-length L1 gene contains 5′ untranslated region, two open reading frames (ORFs) encoded L1ORF1p L1ORF2p, a 3′ terminal polyadenylation site. Compared with protein encompassing reverse transcriptase endonuclease activities, remains to be...
Ligation of TCR and CD28 expressed on T cells via mAbs results in activation capable tumor destruction adoptive immunotherapy. In a murine model, the authors examined vitro conditions utilizing plate-immobilized bead-conjugated that bind to CD3 CD28. Bead-activated tumor-draining lymph node (TDLN) demonstrated superior cytokine (IFN-γ, GM-CSF, IL-2, IL-10) secretion mediated regression more efficiently compared with plate-activated cells. The bead-activated TDLN had significantly higher...
In seismic data acquisition, loss can occur, particularly with the use of streamer systems in marine exploration. These often cause spatial aliasing problems by having close inline intervals and wide crossline to maximize exploration range. To improve resolution direction, various machine learning techniques have been employed for reconstruction. this study, we introduce a 3D cWGAN (conditional Wasserstein generative adversarial network) interpolating data. We evaluate model’s performance...
Receptor-interacting protein kinase 3 (RIP3) is a critical initiator in mediating necroptosis induced by tumor necrosis factor alpha (TNFα) L929 cells, so knockdown of RIP3 inhibits TNFα-induced cell necroptosis. However, was shown to switch apoptosis cells other studies. Therefore, whether blocks the death controversial. In this study, TNFα activated caspase pathway and RIP3-independent had been blocked Z-VAD-FMK (pan-caspase inhibitor) or 8 knockdown, demonstrating that switched...
The successful use of tumor-draining lymph nodes (TDLN) as a source effector cells for cancer immunotherapy depends largely on the immunogenicity tumor drained by well methods secondary in vitro T cell activation and expansion.We transferred bacterial superantigen staphylococcal enterotoxin A (SEA) gene into B16 murine melanoma cells, used them to induce TDLN (SEA TDLN) syngeneic hosts.Wild-type (wt) induced parental was control.In vitro, SEA proliferated more vigorously, produced IFNγ...