A5077713155- NF-κB Signaling Pathways
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Air Quality and Health Impacts
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Neuropeptides and Animal Physiology
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Climate Change and Health Impacts
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Cytokine Signaling Pathways and Interactions
- Arsenic contamination and mitigation
- Invertebrate Immune Response Mechanisms
- Sleep and Wakefulness Research
- Energy and Environment Impacts
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Heat shock proteins research
Changchun University of Chinese Medicine
2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2012-2024
Beijing Institute of Education
2015-2024
Anhui Medical University
2016-2024
Henan Normal University
2021-2024
Jiamusi University
2021-2024
Academy of Military Medical Sciences
2020-2021
Guangxi Medical University
2010-2018
Chinese Institute for Brain Research
2018
Klinikum rechts der Isar
2016
Chemotherapeutic resistance in breast cancer, whether acquired or intrinsic, remains a major clinical obstacle. Thus, increasing tumor cell sensitivity to chemotherapeutic agents will be helpful improving the management of cancer. In present study, we found an induction HO-1 expression doxorubicin (DOX)-treated MDA-MB-231 human adenocarcinoma cells, which showed insensitivity DOX treatment. Knockdown dramatically upregulated incidence death under treatment, indicating that functions as...
Abstract Background Stress, anxiety and depression can cause complex physiological neuroendocrine changes, resulting in increased level of stress related hormone catecholamine, which may constitute a primary mechanism by factors impact gene expression tumors. In the present study, we investigated effects catecholamine stimulation on MMP-7 gastric cancer cells elucidated molecular mechanisms up-regulation through an adrenergic signaling pathway. Results Increased was identified at both mRNA...
ABSTARCT Epidemiological and clinical studies have increasingly shown that fine particulate matter (PM2.5) is associated with a number of pathological respiratory diseases, such as bronchitis, asthma, chronic obstructive pulmonary disease, which share the common feature airway inflammation induced by particle exposure. Thus, understanding how PM2.5 triggers inflammatory responses in system crucial for study toxicity. In current study, we found exposing human bronchial epithelial cells...
Abstract Glucocorticoids are stress‐responsive neuroendocrine mediators and play an important role in malignant progression, especially solid tumours. We demonstrate a novel mechanism by which glucocorticoids modulate p53‐dependent miR‐145 expression HPV‐positive cervical cancer cells through induction of E6 proteins. found that was reduced tissues. Cortisol induced HPV‐E6 suppressed p53 cells. MiR‐145 wild‐type ‐dependent, cortisol‐induced down‐regulation prevented chemotherapy‐induced...
Cross talk between NF-κB and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life death decision under various stresses. Functional suppression of JNK activation by recently proposed as a key cellular survival mechanism contributes to cancer cells escaping from apoptosis. We provide novel scenario proapoptotic role IκB kinase β (IKKβ)–NF-κB, which can act activator pathway through induction GADD45α for triggering MKK4/JNK activation, response stimulation arsenite, therapeutic...
Abstract Trastuzumab is currently used for patients with Her2+ advanced gastric cancer. However, the response rate to trastuzumab among low. The molecular mechanisms underlying resistance in cancer are unknown. Our vitro data show that activation of β2-adrenergic receptor (β2-AR) triggered by catecholamine caused “targeting failure” cells. antitumor activities were significantly impeded chronic stimulation cells and mice bearing human xenografts. Mechanistically, induced upregulation MUC4...
Abstract Previous studies have shown that freeze-dried black raspberry extract fractions inhibit benzo(a)pyrene [B(a)P]–induced transformation of Syrian hamster embryo cells and diol-epoxide [B(a)PDE]–induced activator protein-1 (AP-1) activity in mouse epidermal Cl 41 cells. The phosphotidylinositol 3-kinase (PI-3K)/Akt pathway is critical for B(a)PDE-induced AP-1 activation In the present study, we determined potential involvement PI-3K its downstream kinases on inhibition by fractions,...
Short- and long-term exposure to particulate matter (PM) 2.5 instigates adverse health effect upon the cardiovascular (CV) system. Disclosing molecular events by which PM2.5 evokes CV injuries is essential in developing effective risk-reduction strategy. Here we found that rats after intratracheally instillation with displayed increased circulating level of ANGII, major bioactive peptide renin-angiotensin-system (RAS), resulted from elevation ANGII production vascular endothelium. Further...
Abstract Ambient air temperature is a key factor affecting human health. Female reproductive disorders are representative health risk events under low temperature. However, the mechanism involving in cold-induced female remains largely unknown. mice were intermittently exposed to cold conditions (4 °C) address of on system. Primary granulosa cells (GCs) prepared and cultured (35 or β3-adrenoreceptor agonist, isoproterenol, mimic condition exposure. Western-blot, RT-PCR, co-IP, ELISA,...
Abstract Xuefu Zhuyu Decoction (XZD) is widely used in the treatment of cardiovascular diseases. The purpose this study was to explore pharmacological effects and molecular mechanisms XZD improving hyperlipidemia provide a theoretical framework for clinical application. In study, signaling pathways regulated by were predicted network pharmacology. Molecular docking verify affinity between components target. Furthermore, hyperlipidemic model rats constructed through feeding high‐fat diet....
Tiaogan Jiejiu Tongluo formula (TJTF) is a traditional Chinese medicine for liver disease. The purpose of this study was to explore the protective effects and mechanisms TJTF on nonalcoholic fatty disease (NAFLD) mice. A NAFLD model mice established by combination high-fat diet CCL4 then treated with TJTF. damage tissue observed through histopathology, levels AST, ALT, TG, TC, LDL-C, HDL-C in serum, as well SOD, GSH, MDA were determined using biochemistry or ELISA kit. expression proteins...
Exposure to ultraviolet B (UVB) irradiation from sunlight induces the upregulation of VEGF, a potent angiogenic factor that is critical for mediating angiogenesis-associated photodamage. However, molecular mechanisms related UVB-induced VEGF expression have not been fully defined. Here, we demonstrate one catalytic subunits IκB kinase complex (IKK), IKKα, plays role in mouse embryonic fibroblasts (MEFs), which requires IKKα activity but independent IKKβ, IKKγ and transactivation NF-κB. We...
Abstract One of the health hazards PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both immortalized and primary human bronchial epithelial cells results in a significant upregulation VEGF production, typical signaling event trigger chronic airway inflammation. Further investigations showed strongly induces ATR/CHK1/p53 cascade activation, leading induction DRAM1-dependent autophagy mediate expression by activating Src/STAT3...
Disturbed sleep is closely associated with an increased risk of metabolic diseases. However, the underlying mechanisms circadian clock genes linking and lipid profile abnormalities have not been fully elucidated. This study aimed to explore important role in regulating impaired cholesterol metabolism at early stage deprivation (SD). Sleep disturbance was conducted using SD instrument. Our results showed that serum levels. Concentrations leptin resistin were much lower after SD, but other...
The carcinogenicity of nickel compounds has been well documented both in vitro and vivo; however, the molecular mechanisms by which cause cancers are far from understood. Because suppression apoptosis is thought to contribute carcinogenesis, we investigated implicated nickel-induced anti-apoptotic effect human bronchial epithelial (Beas-2B) cells. We found that exposure Beas-2B cells resulted increased cyclooxygenase-2 (COX-2) expression small interfering RNA (siCOX-2) knockdown COX-2 cell...
Apoptosis is an important cellular response to UV radiation (UVR), but the corresponding mechanisms remain largely unknown. Here we report that p85α regulatory subunit of phosphatidylinositol 3-kinase (PI-3K) exerted a proapoptotic role in UVR through induction tumor necrosis factor alpha (TNF-α) gene expression. This special effect was unrelated PI-3K-dependent signaling pathway. Further evidence demonstrated inducible transcription NFAT3 major downstream target for mediation UVR-induced...
Chronic arsenic exposure is associated with the development of several cardiovascular (CV) diseases, including hypertension, carotid atherosclerosis and microvascular abnormalities. Upregulation systemic aortic angiotensin II (ANGII) signaling has been proposed to contribute arsenic-induced vascular dysfunction. However, underlying mechanisms ANGII augmentation attendant pathological effects on CV system induced by remain largely unknown. Here, we reported that human umbilical vein...