A5034321869- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Neural Networks and Applications
- interferon and immune responses
- Protein Structure and Dynamics
- Autophagy in Disease and Therapy
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Energy and Environment Impacts
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Topic Modeling
- Machine Learning in Bioinformatics
- Advanced Computing and Algorithms
- Air Quality and Health Impacts
- Chemical Synthesis and Analysis
- Brain Tumor Detection and Classification
Guangxi Medical University
2023
Beijing Institute of Education
2016-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2016-2023
Beijing Academy of Artificial Intelligence
2022
University of Chinese Academy of Sciences
2022
Shandong Institute of Automation
2022
Union Hospital
2020
Huazhong University of Science and Technology
2020
Academy of Military Medical Sciences
2020
Chinese Institute for Brain Research
2018
ABSTARCT Epidemiological and clinical studies have increasingly shown that fine particulate matter (PM2.5) is associated with a number of pathological respiratory diseases, such as bronchitis, asthma, chronic obstructive pulmonary disease, which share the common feature airway inflammation induced by particle exposure. Thus, understanding how PM2.5 triggers inflammatory responses in system crucial for study toxicity. In current study, we found exposing human bronchial epithelial cells...
Our previous studies revealed that GADD45α is a liable protein, which undergoes MDM2-dependent constitutive ubiquitination and degradation in resting HepG2 hepatoma cells. Arsenite exposure induces ribosomal stress responses mediated by the protein S7, can block MDM2 activity result accumulation cell apoptosis. In present study, we found one of catalytic subunits IκB kinase (IKK), IKKβ, exerted novel IKKα- NF-κB-independent function stabilizing therefore contributed to...
Our previous studies have revealed that GADD45α is a liable proapoptotic protein, which undergoes MDM2-dependent constitutive ubiquitylation and degradation in resting cancer cells. Under chemotherapeutic agent (such as arsenite, 5-Fu VP-16) exposure, DAPK1 functions novel p53 (also known TP53) kinase, induces phosphorylation of at Ser15 transactivates the target Ets-1, to synergistically repress IKKβ-dependent MDM2 stability, ultimately removes inhibitory effect on GADD45α, resulting...
Abstract Two catalytic subunits of the IKK complex, IKKα and IKKβ, trigger NF-κB activation as well NF-κB-independent signaling events under both physiological pathological conditions. Here we identified NF-κB-unrelated cytoprotective function in promoting autophagy by triggering p53 transactivation upregulation its downstream autophagic mediator, DRAM1, arsenite-treated hepatoma cells, which responses depended on kinase activity. Furthermore, triggered p53/DRAM1-dependent inducing CHK1...
Decoding language from non-invasive brain activity has attracted increasing attention both researchers in neuroscience and natural processing. Due to the noisy nature of recordings, existing work simplified brain-to-word decoding as a binary classification task which is discriminate signal between its corresponding word wrong one. This pairwise task, however, cannot promote development practical neural decoders for two reasons. First, it enumerate all combinations test set, so inefficient...
Predicting the structure of interacting chains is crucial for understanding biological systems and developing new drugs. Large-scale pre-trained Protein Language Models (PLMs), such as ESM2, have shown impressive abilities in extracting biologically meaningful representations protein prediction. In this paper, we show that ESMFold, which has been successful computing accurate atomic structures single-chain proteins, can be adapted to predict heterodimer a lightweight manner. We propose...
听觉系统疾病是人类最常见的感觉系统障碍。由于哺乳动物耳蜗毛细胞的不可再生性，其损伤是听力丧失的主要原因。在感音神经性聋的预防及治疗中，维持毛细胞及内耳中其他类型细胞的正常功能是治疗过程中至关重要的环节。自噬是细胞的一种重要的、高度保守的自我调控机制，在正常的生理过程中起管家的作用，如清除聚集和错误折叠的蛋白质或受损的细胞器。在应激状态下，自噬则具有维持细胞功能和促存活的作用。本文主要介绍近期关于内耳在不同损伤条件下，如遗传性聋、药物性聋、衰老和噪声暴露所致感音神经性聋中自噬的调控机制及研究进展，阐明自噬有望成为治疗听觉系统疾病新的切入点。.