A5072206247- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- interferon and immune responses
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2023-2024
Jiamusi University
2023
Beijing Institute of Education
2023
Our previous studies have revealed that GADD45α is a liable proapoptotic protein, which undergoes MDM2-dependent constitutive ubiquitylation and degradation in resting cancer cells. Under chemotherapeutic agent (such as arsenite, 5-Fu VP-16) exposure, DAPK1 functions novel p53 (also known TP53) kinase, induces phosphorylation of at Ser15 transactivates the target Ets-1, to synergistically repress IKKβ-dependent MDM2 stability, ultimately removes inhibitory effect on GADD45α, resulting...