A5100351015- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Breast Implant and Reconstruction
- Peroxisome Proliferator-Activated Receptors
- Oral and Maxillofacial Pathology
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone and Dental Protein Studies
- Lipid metabolism and disorders
- Protein Tyrosine Phosphatases
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
Changchun University of Chinese Medicine
2025
University of Electronic Science and Technology of China
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Zhongda Hospital Southeast University
2024
Anhui Medical University
2024
Hainan Medical University
2022
Second Affiliated Hospital of Jilin University
2016-2022
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
There is accumulating evidence indicating that long non-coding RNA H19 and its mature product miR-675 play essential roles for tumor growth progression. However, their prognostic value in human head neck squamous cell carcinoma (HNSCC), particular laryngeal carcinoma, remains to be elucidated. In this study, we observed both were significantly overexpressed a cohort of 65 primary samples two HNSCC lines. Importantly, when paired with patient follow-up data, higher expression either or was...
Background Cellular senescence, macrophages infiltration, and vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation participate in the pathophysiology of calcification chronic kidney disease (CKD). Senescent are involved regulation inflammation pathological diseases. In addition, senescent spread senescence to neighboring via Interferon-induced transmembrane protein3 (IFITM3). However, role IFITM3 VSMCs remains unexplored.
Abstract Xuefu Zhuyu Decoction (XZD) is widely used in the treatment of cardiovascular diseases. The purpose this study was to explore pharmacological effects and molecular mechanisms XZD improving hyperlipidemia provide a theoretical framework for clinical application. In study, signaling pathways regulated by were predicted network pharmacology. Molecular docking verify affinity between components target. Furthermore, hyperlipidemic model rats constructed through feeding high‐fat diet....
Increasing evidence has demonstrated that microRNAs (miRNAs) are closely related to the occurrence and development of tumors. MiR-216a-5p, located at 2p16.1, been shown suppress proliferation cancerous cells. However, its expression function in colorectal cancer (CRC) remain unclear.The significance miR-216a-5p CRC was studied by analyzing tissues association with clinicopathological parameters. cells, stably overexpressing miR-216a-5p, were evaluated for cell metastasis using counting kit-8...
Myocardial ischemia-reperfusion (I/R) injury is considered to have a detrimental role in coronary heart disease, which be the leading cause of death worldwide. However, molecular mechanism involved progression myocardial I/R still unclear. The current study aimed investigate expression and function microRNA (miR)-138 process injury. First, miR-138 levels were analyzed both myocardium with control using reverse transcription-quantitative polymerase chain reaction analysis. Then, relationship...
Background: Long non-coding RNA regulator of reprogramming (LINC-RoR) has shown different expressions in a variety tumors as stem cell inducer through regulation. However, its role and regulation mechanisms colorectal cancer (CRC) are still unclear. Materials Methods: Quantitative real-time PCR Western blot were performed to examine LINC-RoR expression paired CRC samples lines. The relationship with clinicopathological characteristics clinical outcomes was analyzed. biological functions...
Long non-coding RNAs (lncRNAs) are widely reported to be involved in the development of human diseases. HLA complex P5 (HCP5) deregulation is associated with various However, function HCP5 diabetic nephropathy (DN) unclear.Human glomerular mesangial cells (HGMCs) were treated high glucose (HG) establish DN cell models. The expression HCP5, miR-93-5p and mobility group AT-hook 2 (HMGA2) mRNA was detected using quantitative polymerase chain reaction (QPCR). Cell proliferation apoptosis...
Cervical cancer (CC) is one of the most common malignancies among women. It has been demonstrated that long coding RNAs (lncRNAs) play a crucial role in CC. The purpose this study was to investigate colon associated transcript 2 (CCAT2) lncRNA CC and elucidate its possible mechanisms action. expression CCAT2, miR-493-5p microRNA (miRNA), mRNA detected using qRT-PCR. Cell viability, proliferation, migration invasion were determined MTT, colony formation, transwell assays, respectively....
Abstract Fibroblast-like synoviocytes (FLSs) are the predominant effector cells in pathological progression of rheumatoid arthritis (RA). Therefore, elucidating underlying molecular mechanism biologic behaviors RA-FLSs will be helpful developing potent targets for treatment RA. We have previously documented that tumor-like exacerbated by urokinase-type plasminogen activator receptor (uPAR), a specifically up-regulated RA-FLSs. Here, we investigate further uPAR and clarify its function...
Gastrin (GAST) is a well-known hormone regulating gastric biofunctions in the secretion of acid and maintaining its structural integrity. Furthermore, dysregulation GAST also involved development various forms cancer. However, there are some limitations for illustrating cellular regulation regulatory mechanisms malignant transformation potential epigenetic regulators systematically. We explored role expression cancer (GC) normal tissues with clinical features investigated relationship...
MicroRNAs (miRs) function as tumor suppressors or oncogenes in development and progression. The present study reported that miR-409-3p was significantly downregulated human papillary thyroid carcinoma (PTC) tissues cell lines. Overexpression of suppressed proliferation induced cycle G0/G1 phase arrest PTC cells. Further revealed the transcriptional regulator cyclin D2 a target miR-409-3p, bound directly to its 3'-untranslated region mimic reduced protein expression levels D2. In addition,...
Glioma has the highest incidence among different tumor types within nervous system, accounting for about 40% of them. Malignant glioma a high invasion and metastasis rate, which leads to poor prognosis patients. By targeting specific genes, microRNAs serve as key regulators in epithelial-mesenchymal transformation (EMT) process, could provide new insights into treatment glioblastomas (GBM). The detailed molecular role that miR-623 plays GBM still remains unclear.The level cells was evaluated...
Patients with rheumatic diseases who receive long-term treatment steroids, immunosuppressants, or biologics are more susceptible to infection pathogens than the general population. In order explore differences in clinical features and prognosis of Corona Virus Disease 2019 (COVID-19) between patients population (family members), a retrospective investigative study was used analyze two populations.
Mesenchymal stem cells (MSCs) are critical in regenerating tissues because they can differentiate into various tissue cells. MSCs interact closely with the microenvironment during repair of damaged tissue. Although regarded as non-healing wounds, tumors be treated by MSCs, which showed satisfactory treatment outcomes previous reports. However, it is largely unknown whether biological behaviors would affected tumor microenvironment. Exploring truth microenvironmental cues driving "wound"...
Muscarinic acetylcholine receptors (MRs) play important roles in the regulation of hepatic fibrosis and receptor agonists antagonists can affect hepatocyte proliferation. However, little is known about impact M 3R subtypes associated signaling pathways on liver injury. The aim this study to explore function mechanism We evaluate injury detect changes related indexes, including alanine aminotransferase (ALT), aspartate (AST), hydroxyproline (HYP), transforming growth factor-β1 (TGF-β1), after...