A5100408476- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Phytochemical and Pharmacological Studies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Phytochemicals and Antioxidant Activities
- Circadian rhythm and melatonin
- Cancer Mechanisms and Therapy
- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Dental Erosion and Treatment
- Telomeres, Telomerase, and Senescence
- Medicinal Plants and Neuroprotection
- Cancer Treatment and Pharmacology
Tianjin Medical University
2021-2025
University of Electronic Science and Technology of China
2025
Shandong Normal University
2025
China Pharmaceutical University
2013-2024
Nanjing University
2018-2024
Nanjing Tech University
2024
Xizang Minzu University
2024
Shihezi University
2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
Psoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, tailoring specific treatment strategies for simultaneously delivering different drugs to action sites in PsA remains challenging. We developed need-based layered dissolving microneedle (MN) system loading immunosuppressant tacrolimus (TAC) anti-inflammatory diclofenac (DIC) layers MNs, i.e., TD-MN, which aims specifically deliver TAC DIC articular cavity, achieving...
Abstract Background Aging‐associated osteoporosis is frequently seen in the elderly clinic, but efficient managements are limited because of unclear nosogenesis. The current study aims to investigate role melatonin on senescent bone marrow stromal cells (BMSCs) and underlying regulating mechanism. Methods Melatonin levels were tested by ELISA. Gene expression profiles performed RNA‐sequencing, enrichment H3K36me2 gene promoters was analyzed Chromatin Immunoprecipitation Sequencing...
Senescence of activated hepatic stellate cells (HSCs) is crucial for the regression liver fibrosis. However, impaired immune clearance can result in accumulation senescent HSCs, exacerbating The activation cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway essential both senescence and innate response. Additionally, specific delivery to HSCs hindered by their inaccessible anatomical location, capillarization sinusoidal endothelial (LSECs), loss substance exchange....
Abstract The Mediterranean diet is acknowledged to be the healthiest dietary pattern around world, mainly based on plant foods from rich flora. It also known increase longevity and have positive effects chronic diseases. This review aimed investigate knowledge about use consumption of edible flowers as part cuisine, ethnobotanical ethnopharmacological studies especially last 10 years, highlight their uses a nutritious functional food. In this review, total 32 flower species used in were...
Background Immunotherapies targeting CD38 have demonstrated salient efficacy in relapsed/refractory multiple myeloma (MM). However, loss of antigen and outgrowth negative plasma cells emerged as a major obstacle clinics. All-trans retinoic acid (ATRA) has been reported to upregulate expression, but the mechanism adaptive genetic background remain unexplored. Methods The ATRA upregulating expression MM is evaluated by flow cytometry. interaction between NSD2 RARα analyzed immunoprecipitation,...
Rheumatoid arthritis (RA) is a kind of autoimmune disease with complex pathogenesis, involving immunological, genetic, and environmental factors. Current treatment for RA mainly focuses on alleviating inflammation, the still hard to be cured completely. microenvironment (RAM) makes even more difficult, synovial hyperplasia, angiogenesis bone destruction causing uncontrollable. Continuous chronic inflammation retention effect (EPR) reactive nitrogen oxygen species (RNOS) in RAM lead vicious...
Inflammation is a crucial element of immune responses, with pivotal roles in host defenses against pathogens. Comprehensive understanding the molecular mechanisms underlying inflammation imperative for developing effective strategies to combat infectious diseases. Here, we conducted screening analysis and identified enkurin domain-containing protein 1 (ENKD1) as promising regulator inflammation. We observed that ENKD1 expression was significantly reduced on activation multiple Toll-like...
The chromosomal t(4;14) (p16;q32) translocation drives high expression of histone methyltransferase nuclear SET domain-containing 2 (NSD2) and plays vital roles in multiple myeloma (MM) evolution progression. However, the mechanisms NSD2-driven epigenomic alterations chemoresistance to proteasome inhibitors (PIs) are not fully understood. Using a CRISPR/Cas9 sgRNA library bone marrow-bearing MM model, we found that hepatoma-derived growth factor (HRP2) was suppressor PIs its downregulation...
Abstract Acquired chemoresistance to proteasome inhibitors is a major obstacle in managing multiple myeloma but key regulators and underlying mechanisms still remain be explored. We find that high level of HP1γ associated with low acetylation modification the bortezomib-resistant cells using SILAC-based acetyl-proteomics assay, higher positively correlated poorer outcomes clinic. Mechanistically, elevated HDAC1 deacetylates at lysine 5 consequently alleviates ubiquitin-mediated protein...
In pursuit of a novel approach in colon cancer therapy, we explored the ability ruthenium baicalein complex to eradicate by efficiently targeting various apoptotic pathways on human cell line and DMH DSS induced murine model colorectal cancer.In this study, provide direct proof chemotherapeutic potential activating p-53 dependent intrinsic apoptosis modulating AKT/mTOR WNT/β-catenin pathways.The was synthesized its characterizations were accomplished through spectroscopic techniques followed...
Abstract Proteasome inhibitors, such as bortezomib (BTZ), represent the key elements in chemotherapy regimens for multiple myeloma (MM), whereas acquired chemoresistance and ultimately relapse remain a major obstacle. In current study, we screened differently expressed cytokines bortezomib-resistant MM cells found that Dickkopf-1 (DKK1) level was remarkably augmented, CD138 significantly suppressed. DKK1 vitro specifically enhanced resistance of to treatment, excessive drove downregulation...
Abstract Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles and mechanism bone marrow stromal cells (BMSCs) in regulating ferroptosis MM remain elusive. Here, we uncovered that were more susceptible ferroptotic induction under the interaction BMSCs using vitro vivo models. Mechanistically, elevated iron level cells, thereby activating steroid biosynthesis pathway, especially production lanosterol, major source reactive...
Elaeagnus moorcroftii Wall. ex Schlecht (EWS) was identified as a suitable food substrate for enhancing the proliferation of Lacticaseibacillus paracasei YL-29 (L.cp29). Metabolomics and pathway analyses were employed to explore effects L.cp29 on EWS juice (EWSJ) secondary metabolites reciprocally, bioactivity fermentation metabolites. Results indicated robust growth (9.87 Log CFU/mL) associated with 59 significantly altered metabolites, encompassing 6 classes Following fermentation,...
PM
In multiple myeloma (MM), bone marrow stromal cells (BMSC) shape a unique niche within the marrow, promoting T-cell dysfunction and driving MM progression; however, precise underlying mechanisms remain elusive. Here, we show that BMSC-mediated reprogramming of led to heightened production CXCL10. CXCL10 orchestrated recruitment γδ T into this was observed in both Vk*MYC 5TGM1 mouse models MM, as well patients experiencing refractory or relapsed MM. Furthermore, dysfunctional exhibited...